{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:56:39Z","timestamp":1771487799627,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,2]],"date-time":"2013-01-02T00:00:00Z","timestamp":1357084800000},"content-version":"vor","delay-in-days":241,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Andrology"],"published-print":{"date-parts":[[2012,5,6]]},"abstract":"<jats:p><jats:bold>ABSTRACT: <\/jats:bold> The objective of this study was to determine the clinical pregnancy rate with 2 inseminations compared to a single intrauterine insemination (IUI) in a given cycle using frozen\u2010thawed donor sperm. This was a retrospective study at a university practice; patients were women using donor sperm. We conducted a comparison of single IUI, intracervical insemination (ICI) followed by an IUI on the next day, and double IUI (2 consecutive days); clinical pregnancy rate was the main outcome measure. The cycle\u2010specific and total pregnancy rates were not significantly different between the 3 protocol groups (306 cycles). The average pregnancy rate over 3 cycles was 10.2% for IUI, 15.3% for ICI\/IUI, and 13.7% for IUI\/IUI (<jats:italic>P<\/jats:italic> = .47). After controlling for repeated measures per subject and age, gravidity, and use of Clomid, there was no significant difference between protocols. The ICI\/IUI (odds ratio [OR] = 1.70; 95% confidence interval [CI], 0.83\u20133.51) and IUI\/IUI (OR = 1.5; 95% CI, 0.52\u20134.33) protocols appeared more likely to result in a clinical pregnancy than the single IUI protocol. Current information on the optimal number of inseminations per cycle using donor sperm is limited. Our large study using 3 protocols found an increase in pregnancy rate with the addition of either an ICI or IUI to a single IUI protocol in a natural or Clomid cycle but did not meet statistical significance. Additional prospective studies are needed to better counsel patients using donor sperm.<\/jats:p>","DOI":"10.2164\/jandrol.111.013276","type":"journal-article","created":{"date-parts":[[2012,5,29]],"date-time":"2012-05-29T16:19:33Z","timestamp":1338308373000},"page":"375-380","source":"Crossref","is-referenced-by-count":9,"title":["Donor Sperm Insemination Cycles: Are Two Inseminations Better Than One?"],"prefix":"10.1002","volume":"33","author":[{"given":"Diana E.","family":"Chavkin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A.","family":"Molinaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea H.","family":"Roe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary D.","family":"Sammel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anuja","family":"Dokras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)01641-1"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000317.pub3"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.11.2298"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep085"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003854"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)54010-2"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/12.7.1494"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(99)00374-X"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)56531-5"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/10.1.153"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.1998.tb02063.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.06.052"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.06.043"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.2307\/2531248"}],"container-title":["Journal of Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.2164%2Fjandrol.111.013276","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.2164\/jandrol.111.013276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T21:28:25Z","timestamp":1698701305000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.2164\/jandrol.111.013276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,6]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,5,6]]}},"alternative-id":["10.2164\/jandrol.111.013276"],"URL":"https:\/\/doi.org\/10.2164\/jandrol.111.013276","archive":["Portico"],"relation":{},"ISSN":["0196-3635","1939-4640"],"issn-type":[{"value":"0196-3635","type":"print"},{"value":"1939-4640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,6]]}}}