{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:58:38Z","timestamp":1790355518216,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,2]],"date-time":"2013-01-02T00:00:00Z","timestamp":1357084800000},"content-version":"vor","delay-in-days":304,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Andrology"],"published-print":{"date-parts":[[2012,3,4]]},"abstract":"<jats:p><jats:bold>ABSTRACT: <\/jats:bold> Diminished vascular endothelial function results in decreased vasodilator capacity and is associated with erectile dysfunction (ED) in patients afflicted with type 2 diabetes. The current study was designed to evaluate whether daily use of sildenafil could alter endothelial function and improve penile rigidity in a group of patients with diabetic ED. A double\u2010blind, placebo\u2010controlled, prospective trial was conducted with 24 men with type 2 diabetes who were randomized into 2 groups: one receiving daily sildenafil (50 mg, n = 12) and the other placebo (n = 12) for 10 weeks. Erectile function was captured subjectively using the International Index of Erectile Function (IIEF\u20105), and endothelial function was objectively monitored via brachial artery flow\u2010mediated dilation. Among the placebo and sildenafil groups, there were no significant differences in average patient age, time from type 2 diabetes diagnosis, duration of ED, or baseline IIEF\u20105 scores. Past medical histories, including smoking, alcohol consumption, hypertension, and hyperlipidemia, were also similar. At the conclusion of the 10\u2010week trial, patients who received daily sildenafil had significantly improved erectile rigidity as captured by IIEF\u20105 (<jats:italic>P<\/jats:italic> &lt; .001) and increased endothelial function via brachial artery flow\u2010mediated dilation (<jats:italic>P<\/jats:italic> &lt; .01). Endothelial function in men with type 2 diabetes was enhanced with daily sildenafil. Improved erectile rigidity and enhanced vascular circulation was noted after 10 weeks of daily sildenafil use.<\/jats:p>","DOI":"10.2164\/jandrol.111.013367","type":"journal-article","created":{"date-parts":[[2012,1,26]],"date-time":"2012-01-26T18:45:52Z","timestamp":1327603552000},"page":"176-180","source":"Crossref","is-referenced-by-count":39,"title":["Daily Use of Sildenafil Improves Endothelial Function in Men With Type 2 Diabetes"],"prefix":"10.1002","volume":"33","author":[{"given":"Ling","family":"Deyoung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason R.","family":"Kovac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald B.","family":"Brock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756287209344992"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3901513"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-0883"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.09.005"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.8.1336"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.139451"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2008.01014.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000155252.23933.2D"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2009.01624.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000156407.59837.C1"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2007.02.006"},{"key":"e_1_2_5_13_1","first-page":"853","article-title":"Endothelial dysfunction in diabetes mellitus","volume":"3","author":"Hadi HA","year":"2007","journal-title":"Vasc Health Risk Manag"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.563213"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2003.11.001"},{"key":"e_1_2_5_16_1","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nature01323","article-title":"Inflammation in atherosclerosis","volume":"42","author":"Libby P.","year":"2002","journal-title":"Nature"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.04.042"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2004.10.002"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.03.002"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707459"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.89.3.251"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.74.3.247"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.921"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.08.025"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.08.004"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-1326.2002.00212.x"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00522-6"}],"container-title":["Journal of Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.2164%2Fjandrol.111.013367","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.2164\/jandrol.111.013367","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T05:34:40Z","timestamp":1698644080000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.2164\/jandrol.111.013367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,4]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,3,4]]}},"alternative-id":["10.2164\/jandrol.111.013367"],"URL":"https:\/\/doi.org\/10.2164\/jandrol.111.013367","archive":["Portico"],"relation":{},"ISSN":["0196-3635","1939-4640"],"issn-type":[{"value":"0196-3635","type":"print"},{"value":"1939-4640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,4]]}}}