{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:32:55Z","timestamp":1771633975101,"version":"3.50.1"},"reference-count":98,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin. Pharmacokinet."],"published-print":{"date-parts":[[1977,2]]},"DOI":"10.2165\/00003088-197702010-00003","type":"journal-article","created":{"date-parts":[[2007,12,5]],"date-time":"2007-12-05T10:31:53Z","timestamp":1196850713000},"page":"32-44","source":"Crossref","is-referenced-by-count":181,"title":["Protein Binding and Kinetics of Drugs in Liver Diseases"],"prefix":"10.1007","volume":"2","author":[{"given":"Terrence F.","family":"Blaschke","sequence":"first","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2012,12,13]]},"reference":[{"key":"2010032_CR1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/BF00567126","volume":"8","author":"M. Affrime","year":"1975","unstructured":"Affrime, M. and Reidenberg, M.M.: The protein binding of some drugs in plasma from patients with alcoholic liver disease. European Journal of Clinical Pharmacology 8: 267\u2013269 (1975).","journal-title":"European Journal of Clinical Pharmacology"},{"key":"2010032_CR2","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1365-2362.1974.tb00383.x","volume":"4","author":"P.B. Andreason","year":"1974","unstructured":"Andreason, P.B.; Ranek, L.; Statland B.E. and Tygstrup, N.: Clearance of Antipyrine-dependence of quantitative liver function. European Journal of Clinical Investigation. 4: 129\u2013134 (1974).","journal-title":"European Journal of Clinical Investigation"},{"key":"2010032_CR3","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1002\/cpt19741661059","volume":"16","author":"P.B. Adreasen","year":"1974","unstructured":"Adreasen, P.B. and Vesell, E.S.: Comparison of plasma levels of antipyrine, tolbutamide, and warfarin after oral and intravenous administration. Clinical Pharmacology and Therapeutics 16: 1059\u20131065 (1974).","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"2010032_CR4","first-page":"130","volume":"6","author":"F. Azzollini","year":"1972","unstructured":"Azzollini, F.; Gazzaniga, A.; Lodola, E. and Natangelo, R.: Elimination of chloramphenicol and thiamphenicol in subjects with cirrhosis of the liver. International Journal of Clinical Pharmacology 6: 130\u2013134 (1972).","journal-title":"International Journal of Clinical Pharmacology"},{"key":"2010032_CR5","volume-title":"Chapter in Die Eiweisskorper des Blutplasmas","author":"H. Bennhold","year":"1938","unstructured":"Bennhold, H.: Die vekikelfunction der bluteiweisskorper. Chapter in Die Eiweisskorper des Blutplasmas by H. Bennhold, E. Kylin and S. Rusznyak. Steinkopf, Leipzig (1938)."},{"key":"2010032_CR6","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/cpt1969103320","volume":"10","author":"B.A. Berkowitz","year":"1969","unstructured":"Berkowitz, B.A.; Asling, J.H.; Shnider, S.M. and Way, E.L.: Relationship of pentazocine plasma levels to pharmacologic activity in man. Clinical Pharmacology and Therapeutics 10: 320\u2013328 (1969).","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"2010032_CR7","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/S0025-7125(16)32100-9","volume":"58","author":"M. Black","year":"1974","unstructured":"Black, M. Liver disease and drug therapy in \u2018symposium on Individualisation of drug therapy.\u2019 Medical Clinics of North America 58: 1051\u20131057 (1974).","journal-title":"Medical Clinics of North America"},{"key":"2010032_CR8","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/cpt1975176685","volume":"17","author":"T.F. Blaschke","year":"1975","unstructured":"Blaschke, T.F.; Meffin, P.J.; Melmon, K.L. and Rowland, M.: Influence of acute viral hepatitis on Phenytoin kinetics and protein binding. Clinical Pharmacology and Therapeutics 17: 685\u2013690 (1975).","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"2010032_CR9","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/0006-2952(69)90318-9","volume":"18","author":"D. Borga","year":"1969","unstructured":"Borga, D.; Azarnoff, D.; Forshell, G.P. and Sjoqvist, F.: Plasma protein binding of tricyclic antidepressants in man. Biochemical Pharmacology 18: 2135\u20132143 (1969).","journal-title":"Biochemical Pharmacology"},{"key":"2010032_CR10","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/cpt197620181","volume":"20","author":"R.A. Branch","year":"1976","unstructured":"Branch, R.A.; James, J.A. and Read, A.E.: The clearance of antipyrine and indocyanine green in normal subjects and in patients with chronic liver disease. Clinical Pharmacology and Therapeutics 20: 81\u201389 (1976a).","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"2010032_CR11","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1365-2125.1976.tb00599.x","volume":"3","author":"R.A. Branch","year":"1976","unstructured":"Branch, R.A.; James, J. and Read, E.A.: A study of factors influencing drug disposition in chronic liver disease, using the model drug (+)-propranolol. British Journal of Clinical Pharmacology 3: 243\u2013249 (1976b).","journal-title":"British Journal of Clinical Pharmacology"},{"key":"2010032_CR12","first-page":"687","volume":"1","author":"R.A. Branch","year":"1973","unstructured":"Branch, R.A.; Nies, A.S. and Shand, D.G.: The disposition of propranolol VIII. General implications of the effects of liver blood flow on elimination from the perfused rat liver. Drug Metabolism and Disposition 1: 687\u2013690 (1973).","journal-title":"Drug Metabolism and Disposition"},{"key":"2010032_CR13","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1172\/JCI107647","volume":"53","author":"R.A. Branch","year":"1974","unstructured":"Branch, R.A.; Shand, D.G.; Wilkinson, G.R. and Nies, A.S.: Increased clearance of antipyrine and d-propranolol after phenobarbital treatment in the monkey. Relative contributions of enzyme and induction and increased hepatic blood flow. Journal of Clinical Investigation 53: 1101\u20131107 (1974).","journal-title":"Journal of Clinical Investigation"},{"key":"2010032_CR14","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1600-0773.1971.tb03302.x","volume":"329","author":"A. Breckenridge","year":"1971","unstructured":"Breckenridge, A.: Pathophysiological factors influencing drug kinetics. Acta Pharmacologica Toxicologica (Suppl 3) 29: 225\u2013232 (1971).","journal-title":"Acta Pharmacologica Toxicologica (Suppl"},{"key":"2010032_CR15","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/cpt1975184433","volume":"18","author":"D.D. Breimer","year":"1975","unstructured":"Breimer, D.D.; Zilly, W. and Richter, E.: Pharmacokinetics of hexobarbital in acute hepatitis and after apparent recovery. Clinical Pharmacology and Therapeutics 18: 433\u2013440 (1975).","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"2010032_CR16","first-page":"85","volume":"98","author":"B.B. Brodie","year":"1950","unstructured":"Brodie, B.B.; Mark, L.C.; Papper, E.M.; Leif, P.A.; Bernstein, E. and Rovenstine, E.A.: The fate of thiopental in man and a method for its estimation in biological material. J. Pharmacol. exp. Ther. 98: 85\u201396 (1950).","journal-title":"J. Pharmacol. exp. Ther."},{"key":"2010032_CR17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/cpt1974161part151","volume":"16","author":"S.F. Brunk","year":"1974","unstructured":"Brunk, S.F. and Delle, M.: Morphine metabolism in man. Clinical Pharmacology and Therapeutics 16: 51\u201357 (1974).","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"2010032_CR18","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/j.2042-7158.1976.tb02841.x","volume":"28","author":"J.A. Clements","year":"1976","unstructured":"Clements, J.A. and Prescott, L.F.: Data point weighting in pharmacokinetic analysis: intravenous paracetamol in man. Journal of Pharmacy and Pharmacology 28: 707\u2013709 (1976).","journal-title":"Journal of Pharmacy and Pharmacology"},{"key":"2010032_CR19","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1126\/science.178.4061.576","volume":"178","author":"A.H. Conney","year":"1972","unstructured":"Conney, A.H. and Burns, J.J.: Metabolic interactions among environmental chemicals and drugs. Science 178: 576\u2013586 (1972).","journal-title":"Science"},{"key":"2010032_CR20","doi-asserted-by":"crossref","first-page":"280","DOI":"10.2165\/00003088-197601040-00003","volume":"1","author":"J. Crooks","year":"1976","unstructured":"Crooks, J.; O\u2019Malley, K. and Stevenson, I.H.: Pharmacokinetics in the elderly. Clinical Pharmacokinetics 1: 280\u2013296 (1976).","journal-title":"Clinical Pharmacokinetics"},{"key":"2010032_CR21","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.2042-7158.1970.tb08496.x","volume":"22","author":"S.H. Curry","year":"1970","unstructured":"Curry, S.H.: Plasma protein binding of chlorpromazine. Journal of Pharmacy and Pharmacology 22: 193\u2013197 (1970).","journal-title":"Journal of Pharmacy and Pharmacology"},{"key":"2010032_CR22","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1749-6632.1973.tb20480.x","volume":"226","author":"P.G. Dayton","year":"1973","unstructured":"Dayton, P.G.; Israili, Z.H. and Perel, J.M.: Influence of binding on drug metabolism and distribution. Annals of New York Academy of Science 226: 172\u2013194 (1973).","journal-title":"Annals of New York Academy of Science"},{"key":"2010032_CR23","doi-asserted-by":"crossref","first-page":"126","DOI":"10.2165\/00003088-197601020-00004","volume":"1","author":"L. Dettli","year":"1976","unstructured":"Dettli, L.: Drug dosage in renal disease. Clinical Pharmacokinetics 1: 126\u2013134 (1976).","journal-title":"Clinical Pharmacokinetics"},{"key":"2010032_CR24","first-page":"318","volume":"191","author":"S.H. Dromgoole","year":"1974","unstructured":"Dromgoole, S.H.: The binding capacity of albumin and renal disease. Journal of Pharmacology and Experimental Therapeutics 191: 318\u2013323 (1974).","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"2010032_CR25","first-page":"114","volume":"186","author":"G.H. Evans","year":"1973","unstructured":"Evans, G.H.; Nies, A.S. and Shand, D.G.: The disposition of propranolol III: decreased half-life and volume of distribution as a result of plasma binding in man, monkey, dog, and rat. J. Pharmacol. exp. Ther. 186: 114\u2013122 (1973).","journal-title":"J. Pharmacol. exp. Ther."},{"key":"2010032_CR26","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/cpt1973144part1494","volume":"14","author":"G.H. Evans","year":"1973","unstructured":"Evans, G.H. and Shand, D.G.: Disposition of propranolol VI: independent variation in steady-state circulating drug concentrations and half-life as a result of plasma drug binding in man. Clinical Pharmacology and Therapeutics 14: 494\u2013502 (1973).","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"2010032_CR27","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/BF01062145","volume":"2","author":"E.R. Garrett","year":"1974","unstructured":"Garrett, E.R.; Bres, J.; Schnelle, K. and Rolf, L.L.: Pharmacokinetics of saturably metabolised amobarbital. Journal of Pharmacokinetics and Biopharmacology 2: 43\u2013103 (1974).","journal-title":"Journal of Pharmacokinetics and Biopharmacology"},{"key":"2010032_CR28","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1111\/j.2042-7158.1973.tb09987.x","volume":"25","author":"B.G. Gazzard","year":"1973","unstructured":"Gazzard, B.G.; Ford-Hutchinson, A.W.; Smith, M.J.H. and Williams, R.: The binding of paracetamol to plasma proteins of man and pig. Journal of Pharmacology 25: 964\u2013967 (1973).","journal-title":"Journal of Pharmacology"},{"key":"2010032_CR29","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1097\/00000542-197505000-00007","volume":"42","author":"M.M. Ghoneim","year":"1975","unstructured":"Ghoneim, M.M. and Pandya, H.: Plasma protein binding of thiopental in patients with impaired renal or hepatic function. Anesthesiology 42: 545\u2013549 (1975).","journal-title":"Anesthesiology"},{"key":"2010032_CR30","volume-title":"Pharmacokinetics","author":"M. Gibaldi","year":"1975","unstructured":"Gibaldi, M. and Perrier, D.: Pharmacokinetics (Marcel Dekker, Inc. New York, 1975)."},{"key":"2010032_CR31","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1749-6632.1971.tb46890.x","volume":"179","author":"J.R. Gillette","year":"1971","unstructured":"Gillette, J.R.: Factors affecting drug metabolism. Annals of New York Academy of Science 179: 43\u201366 (1971).","journal-title":"Annals of New York Academy of Science"},{"key":"2010032_CR32","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1749-6632.1973.tb20464.x","volume":"226","author":"J.R. Gillette","year":"1973","unstructured":"Gillette, J.R.: Overview of drug-protein binding. Annals of New York Academy of Science 226: 6\u201317 (1973).","journal-title":"Annals of New York Academy of Science"},{"key":"2010032_CR33","first-page":"445","volume":"96","author":"A.J. Glazko","year":"1949","unstructured":"Glazko, A.J.; Wolf, L.M.; Bill, W.A. and Bratton, A.C.: Biochemical studies on chloramphenicol II. Tissue distribution and excretion studies. Journal of Pharmacology and Experimental Therapeutics 96: 445\u2013449 (1949).","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"2010032_CR34","first-page":"102","volume":"1","author":"A. Goldstein","year":"1949","unstructured":"Goldstein, A.: The interactions of drugs and plasma proteins. Pharmacological Reviews 1: 102\u2013165 (1949).","journal-title":"Pharmacological Reviews"},{"key":"2010032_CR35","doi-asserted-by":"crossref","unstructured":"Gordon, R.C.; Regamey, C. and Kirby, W.M.M.: Serum protein binding of erythromycin, lincomycin and clindamycin. Journal of Pharmacology and Science 1074\u20131077 (1973).","DOI":"10.1002\/jps.2600620704"},{"key":"2010032_CR36","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/cpt1975183305","volume":"18","author":"L.F. Gram","year":"1975","unstructured":"Gram, L.F.; Overo, K.F.: First pass metabolism of nortriptyline in man. Clinical Pharmacology and Therapeutics 18: 305\u2013314 (1975).","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"2010032_CR37","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1056\/NEJM197106242842504","volume":"284","author":"H. Grausz","year":"1971","unstructured":"Grausz, H. and Schmid, R.: Reciprocal relation between plasma albumin level and hepatic sulfobromophthalein removal. New England Journal of Medicine 284: 1403\u20131406 (1971).","journal-title":"New England Journal of Medicine"},{"key":"2010032_CR38","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/BF00560341","volume":"7","author":"D.J. Greenblatt","year":"1974","unstructured":"Greenblatt, D.J. and Koch-Weser, J.: Clinical toxicity of chlordiazepoxide and diazepam in relation to serum albumin concentration: a report from the Boston Collaborative Drug Surveillance Program. European Journal of Clinical Pharmacology 7: 259\u2013262 (1974).","journal-title":"European Journal of Clinical Pharmacology"},{"key":"2010032_CR39","first-page":"416","volume":"195","author":"R. Gugler","year":"1975","unstructured":"Gugler, R.; Lain, P. and Azarnoff, D.L.: Effect of portocaval shunt on the disposition of drugs with and without first pass effect. Journal of Pharmacology and Experimental Therapeutics 195: 416\u2013423 (1975).","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"2010032_CR40","first-page":"1801","volume":"23","author":"V.H. Held","year":"1973","unstructured":"Held, V.H.; Eisert, R. and Oldershausen, H.F.: Pharmacokinetik von Glymidine (Glycodiazin) and tolbutamid bei akuten und chronischen lebershaden. Arzneimittel-Forschung 23: 1801\u20131807 (1973).","journal-title":"Arzneimittel-Forschung"},{"key":"2010032_CR41","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1056\/NEJM197412262912605","volume":"291","author":"G.W. Hepner","year":"1974","unstructured":"Hepner, G.W. and Vesell, E.S.: Assessment of aminopyrine metabolism in man by breath analysis after oral administration of 14C-aminopyrine. New England Journal of Medicine 291: 1384\u20131388 (1974).","journal-title":"New England Journal of Medicine"},{"key":"2010032_CR42","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1128\/AAC.9.3.498","volume":"9","author":"D.R. Hinthorn","year":"1976","unstructured":"Hinthorn, D.R.; Baker, L.H.; Romig, D.A.; Hassanein, K. and Liu, C.: Use of clindamycin in patients with liver disease. Antimicrobial Agents Chemotherapy 9: 495\u2013501 (1976).","journal-title":"Antimicrobial Agents Chemotherapy"},{"key":"2010032_CR43","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/cpt1974153276","volume":"15","author":"W.D. Hooper","year":"1974","unstructured":"Hooper, W.D.; Bochner, F.; Endre, M.J. and Tyrer, J.H.: Plasma protein binding of diphenyl-hydantoin. Effects of sex hormones, renal and hepatic disease. Clinical Pharmacology and Therapeutics 15: 276\u2013282 (1974).","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"2010032_CR44","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/cpt1976195part1546","volume":"19","author":"S.N. Hunt","year":"1976","unstructured":"Hunt, S.N.; Jusko, W.J. and Yurchak, A.M.: Effect of smoking on theophylline disposition. Clinical Pharmacology and Therapeutics 19: 546\u2013551 (1976).","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"2010032_CR45","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/cpt1972133349","volume":"13","author":"J.W. Jenne","year":"1972","unstructured":"Jenne, J.W.; Wyze, E.; Rood, F.S. and MacDonald, F.M.: Pharmacokinetics of theophylline: application to adjustment of the clinical dose of aminophylline. Clinical Pharmacology and Therapeutics 13: 349\u2013360 (1972).","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"2010032_CR46","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3109\/03602537608995839","volume":"5","author":"W.J. Jusko","year":"1976","unstructured":"Jusko, W.J. and Gretch, M.: Plasma and tissue protein binding of drugs in pharmacokinetics. Drug Metabolism Reviews 5: 43\u2013140 (1976).","journal-title":"Drug Metabolism Reviews"},{"key":"2010032_CR47","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/cpt1973144part1552","volume":"14","author":"D. Kadar","year":"1973","unstructured":"Kadar, D.; Inaba, T.; Endrenyi, L.; Johnson, G.E. and Kalow, W.: Comparative drug elimination capacity in man \u2014 glutethimide amobarbital, antipyrine and sulfinpyrazone. Clinical Pharmacology and Therapeutics 14: 552\u2013560 (1973).","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"2010032_CR48","first-page":"47","volume":"3","author":"G. Kellermann","year":"1975","unstructured":"Kellermann, G.; Luyten-Kellermann, M.; Homing, M.G. and Stafford, M.: Correlation of aryl hydrocarbon hydroxylase activity of human lymphocyte cultures and plasma elimination rates for antipyrine and phenylbutazone. Drug Metabolism and Disposition 3: 47\u201350 (1975).","journal-title":"Drug Metabolism and Disposition"},{"key":"2010032_CR49","doi-asserted-by":"crossref","first-page":"204","DOI":"10.2165\/00003088-197601030-00003","volume":"1","author":"U. Klotz","year":"1976","unstructured":"Klotz, U.: Pathophysiological and disease-induced changes in drug distribution volume: Pharmacokinetic implications. Clinical Pharmacokinetics 1: 204\u2013218 (1976).","journal-title":"Clinical Pharmacokinetics"},{"key":"2010032_CR50","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1172\/JCI107938","volume":"55","author":"U. Klotz","year":"1975","unstructured":"Klotz, U.; Avant, G.R.; Hoyumpa, A.; Schenker, S. and Wilkinson, G.R.: The effects of age and liver disease on the disposition and elimination of diazepam in adult man. Journal of Clinical Investigation 55: 347\u2013359 (1975).","journal-title":"Journal of Clinical Investigation"},{"key":"2010032_CR51","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/cpt1974164667","volume":"16","author":"U. Klotz","year":"1974","unstructured":"Klotz, U.; McHorse, T.S.; Wilkinson, G.R. and Schenker, S.: The effect of cirrhosis on the disposition and elimination of meperidine in man. Clinical Pharmacology and Therapeutics 16: 667\u2013675 (1974).","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"2010032_CR52","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1056\/NEJM197602052940605","volume":"294","author":"J. Koch-Weser","year":"1976","unstructured":"Koch-Weser, J. and Sellers, E.M.: Binding of drugs to serum albumin. New England Journal of Medicine 294: 311\u2013316, 526\u2013531 (1976).","journal-title":"New England Journal of Medicine"},{"key":"2010032_CR53","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/cpt1974155454","volume":"15","author":"R. Koysooko","year":"1974","unstructured":"Koysooko, R.; Ellis, E.F. and Levy, G.: Relationship between theophylline concentration in plasma and saliva of man. Clinical Pharmacology and Therapeutics 15: 454\u2013460 (1974).","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"2010032_CR54","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/S0140-6736(68)92292-7","volume":"1","author":"A.J. Levi","year":"1968","unstructured":"Levi, A.J.; Sherlock, S. and Walker, D.: Phenylbutazone and isoniazid metabolism in patients with liver disease in relation to previous drug therapy. Lancet 1: 1275\u20131279 (1968).","journal-title":"Lancet"},{"key":"2010032_CR55","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/cpt1975184475","volume":"18","author":"J.P. Lewis","year":"1975","unstructured":"Lewis, J.P. and Jusko, W.J.: Pharmacokinetics of ampicillin in cirrhosis. Clinical Pharmacology and Therapeutics 18: 475\u2013484 (1975).","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"2010032_CR56","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1172\/JCI106060","volume":"48","author":"D.S. Lukas","year":"1969","unstructured":"Lukas, D.S. and DeMartino, A.G.: Binding of digitoxin and some related cardenolides to human plasma proteins. Journal of Clinical Investigation 48: 1041\u20131053 (1969).","journal-title":"Journal of Clinical Investigation"},{"key":"2010032_CR57","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/cpt197517121","volume":"17","author":"L.E. Mather","year":"1975","unstructured":"Mather, L.E.; Tucker, G.T.; Pflug, A.E.; Lindop, M.J. and Wilkerson, C.: Meperidine kinetics in man. Intravenous injection in surgical patients and volunteers. Clinical Pharmacology and Therapeutics 17: 21\u201330 (1975).","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"2010032_CR58","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1476-5381.1972.tb07292.x","volume":"44","author":"G.E. Mawer","year":"1972","unstructured":"Mawer, G.E.; Miller, N.E. and Turnberg, L.A.: Metabolism of amylobarbitone in patients with chronic liver disease. British Journal of Pharmacology 44: 549\u2013560 (1972).","journal-title":"British Journal of Pharmacology"},{"key":"2010032_CR59","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1042\/cs0430143","volume":"43","author":"J.D. Maxwell","year":"1972","unstructured":"Maxwell, J.D.; Carrella, M.; Parkes, J.D.; Williams, R.; Mould, G.P. and Curry, S.H.: Plasma disappearance and cerebral effects of chlorpromazine in cirrhosis. Clinical Science 43: 143\u2013151 (1972).","journal-title":"Clinical Science"},{"key":"2010032_CR60","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0016-5085(75)80289-7","volume":"68","author":"T.S. McHorse","year":"1975","unstructured":"McHorse, T.S.; Wilkinson, G.R.; Johnson, R.F. and Schenker, S.: Effect of acute viral hepatitis on the disposition and elimination of meperidine. Gastroenterology 68: 775\u2013780 (1975).","journal-title":"Gastroenterology"},{"key":"2010032_CR61","first-page":"845","volume":"69","author":"C.L. Mendenhall","year":"1975","unstructured":"Mendenhall, C.L.; Robinson, J.D. and Morgan, D.D.: Chlordiazepoxide (Librium) therapy in hepatic insufficiency (Abstract). Gastroenterology 69: 845 (1975).","journal-title":"Gastroenterology"},{"key":"2010032_CR62","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1002\/jps.2600570601","volume":"57","author":"M.C. Meyer","year":"1968","unstructured":"Meyer, M.C. and Guttman, D.E.: The binding of drugs by plasma proteins. Journal of Pharmaceutical Sciences 57: 895\u2013898 (1968).","journal-title":"Journal of Pharmaceutical Sciences"},{"key":"2010032_CR63","first-page":"231","volume-title":"Drug Interactions","author":"A.S. Nies","year":"1974","unstructured":"Nies, A.S.; Shand, D.G. and Branch, R.A.: Hemodynamic drug interactions: the effects of altering hepatic blood flow on drug disposition; in Morselli, Garattini and Cohen (Eds) Drug Interactions, pp.231\u2013240 (Raven Press, New York 1974)."},{"key":"2010032_CR64","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2165\/00003088-197601020-00005","volume":"1","author":"A.S. Nies","year":"1976","unstructured":"Nies, A.S.; Shand, D.G. and Wilkinson, G.R.: Altered hepatic blood flow and drug disposition. Clinical Pharmacokinetics 1: 135\u2013155 (1976).","journal-title":"Clinical Pharmacokinetics"},{"key":"2010032_CR65","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/cpt197517131","volume":"17","author":"G.D. Olsen","year":"1975","unstructured":"Olsen, G.D.: Morphine binding to human plasma proteins. Clinical Pharmacology and Therapeutics 17: 31\u201335 (1975).","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"2010032_CR66","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/cpt1975176677","volume":"17","author":"G.D. Olsen","year":"1975","unstructured":"Olsen, G.D.; Bennett, W.M. and Porter, G.A.: Morphine and Phenytoin binding to plasma proteins in renal and hepatic failure. Clinical Pharmacology and Therapeutics 17: 677\u2013684 (1975).","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"2010032_CR67","first-page":"178","volume":"25","author":"R.A. O\u2019Reilly","year":"1971","unstructured":"O\u2019Reilly, R.A.; Welling. P.G. and Wagner, J.G.: Pharmacokinetics of warfarin following intravenous administration to man. Thrombosis of Diathesis Haemorrhagica 25: 178\u2013186 (1971).","journal-title":"Thrombosis of Diathesis Haemorrhagica"},{"key":"2010032_CR68","volume-title":"Hepatic clearance of drugs: Discrimination between two models","author":"H.K.S. Pang","year":"1975","unstructured":"Pang, H.K.S. and Rowland, M.: Hepatic clearance of drugs: Discrimination between two models, in Abstracts of the 16th National Meeting of the APhA Academy of Pharmaceutical Sciences, San Francisco, Vol. 2, Washington, D.C. (1975)."},{"key":"2010032_CR69","first-page":"17","volume":"191","author":"D. Perrier","year":"1974","unstructured":"Perrier, D. and Gibaldi, M.: Clearance and biologic half life as indices of intrinsic hepatic metabolism. Journal of Pharmacology and Experimental Therapeutics 191: 17\u201324 (1974).","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"2010032_CR70","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/S0140-6736(69)90766-1","volume":"2","author":"L.F. Prescott","year":"1969","unstructured":"Prescott, L.F.: Pharmacokinetic drug interactions. Lancet 2: 1239\u20131243 (1969).","journal-title":"Lancet"},{"key":"2010032_CR71","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S0022-3476(71)80369-4","volume":"78","author":"A. Rane","year":"1971","unstructured":"Rane, A.; Lunde, P.K.M.; Jailing, B.; Yaffe, S. and Sjoqvist, F.: Plasma protein binding of diphenylhydantoin in normal and hyperbilirubinemic infants. Journal of Pediatrics 78: 877\u2013882 (1971).","journal-title":"Journal of Pediatrics"},{"key":"2010032_CR72","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2165\/00003088-197601020-00003","volume":"1","author":"M.M. Reidenberg","year":"1976","unstructured":"Reidenberg, M.M.: The binding of drugs to plasma proteins from patients with poor renal function. Clinical Pharmacokinetics 1: 121\u2013125 (1976).","journal-title":"Clinical Pharmacokinetics"},{"key":"2010032_CR73","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1749-6632.1973.tb20474.x","volume":"226","author":"M.M. Reidenberg","year":"1973","unstructured":"Reidenberg, M.M. and Affrime, M.: Influence of disease on binding of drugs to plasma proteins. Annals of New York Academy of Science 226: 115\u2013126 (1973).","journal-title":"Annals of New York Academy of Science"},{"key":"2010032_CR74","first-page":"87","volume-title":"Pharmacology and Pharmacokinetics","author":"S. Reigelman","year":"1974","unstructured":"Reigelman, S. and Rowland, M.: Effect of route of administration of drug disposition; in Teorell, Dedrick, and Condliffe (Eds) Pharmacology and Pharmacokinetics, p.87\u2013104 (Plenum Press, New York-London, 1974)."},{"key":"2010032_CR75","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF01059626","volume":"1","author":"M. Rowland","year":"1973","unstructured":"Rowland, M.; Benet, L.Z. and Graham, G.G.: Clearance concepts in pharmacokinetics. Journal of Pharmacokinetics of Biopharmaceutics 1: 123\u2013136 (1973).","journal-title":"Journal of Pharmacokinetics of Biopharmaceutics"},{"key":"2010032_CR76","first-page":"53","volume-title":"Effect of Disease States on Drug Pharmacokinetics","author":"M. Rowland","year":"1976","unstructured":"Rowland, M.; Blaschke, T.F.; Meffin, P.J. and Williams, R.L.: Pharmacokinetics in disease states modifying hepatic and metabolic function, in L.Z. Benet, Ed. Effect of Disease States on Drug Pharmacokinetics, p. 53\u201374. (American Pharmaceutical Association, Academy of Pharmaceutical Sciences, Washington, D.C, 1976)."},{"key":"2010032_CR77","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1172\/JCI102985","volume":"33","author":"J.T. Sessions","year":"1954","unstructured":"Sessions, J.T.; Minkel, H.P.; Bullard, J.C. and Ingelfinger, F.J.: The effect of barbiturates in patients with liver disease. Journal of Clinical Investigation 33: 1116\u20131127 (1954).","journal-title":"Journal of Clinical Investigation"},{"key":"2010032_CR78","first-page":"424","volume":"195","author":"D.G. Shand","year":"1975","unstructured":"Shand, D.G.; Kornhauser, D.M. and Wilkinson, G.R.: Effects of route of administration and blood flow on hepatic drug elimination. Journal of Pharmacology and Experimental Therapeutics 195: 424\u2013432 (1975).","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"2010032_CR79","doi-asserted-by":"crossref","first-page":"420","DOI":"10.7326\/0003-4819-84-4-420","volume":"84","author":"H.J. Shull","year":"1976","unstructured":"Shull, H.J.; Wilkinson, G.R.; Johnson, R. and Schenker, S.: Normal disposition of oxazepam in acute viral hepatitis and cirrhosis. Annals of Internal Medicine 84: 420\u2013425 (1976).","journal-title":"Annals of Internal Medicine"},{"key":"2010032_CR80","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0021-9258(18)56808-3","volume":"179","author":"R. Soberman","year":"1949","unstructured":"Soberman, R.; Brodie, B.B.; Levy, B.B.; Axelrod, J.; Hollander, V. and Steele, J.M.: The use of antipyrine in the measurement of total body water in man. Journal of Biological Chemistry 179: 31\u201342 (1949).","journal-title":"Journal of Biological Chemistry"},{"key":"2010032_CR81","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/cpt1976203365","volume":"20","author":"M.F. Sorrell","year":"1976","unstructured":"Sorrell, M.F.; Burnett, D.A.; Tuma, D.J. and Barak, A.J.: Paradoxical urinary excretion of d-glucaric acid in acute viral hepatitis. Clinical Pharmacology and Therapeutics 20: 365\u2013368 (1976).","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"2010032_CR82","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/j.1552-4604.1976.tb01531.x","volume":"16","author":"J.J. Thiessen","year":"1976","unstructured":"Thiessen, J.J.; Sellers, E.M.; Denbergh, P. and Dolman, L.: Plasma protein binding of diazepam and tolbutamide in chronic alcoholics. Journal of Clinical Pharmacology 16: 345\u2013351 (1976).","journal-title":"Journal of Clinical Pharmacology"},{"key":"2010032_CR83","doi-asserted-by":"crossref","first-page":"175","DOI":"10.7326\/0003-4819-82-2-175","volume":"82","author":"W.L. Thompson","year":"1975","unstructured":"Thompson, W.L.; Johnson, A.D. and Maddrey, W.L.: Diazepam and paraldehyde for treatment of severe delirium tremens: a controlled trial. Annals of Internal Medicine 82: 175\u2013180 (1975).","journal-title":"Annals of Internal Medicine"},{"key":"2010032_CR84","doi-asserted-by":"crossref","first-page":"499","DOI":"10.7326\/0003-4819-78-4-499","volume":"78","author":"P.D. Thomson","year":"1973","unstructured":"Thomson, P.D.; Melmon, K.L.; Richardson, J.A.; Cohn, K.; Steinbrunn, W.; Cudihie, R. and Rowland, M.: Lidocaine pharmacokinetics in advanced heart failure, liver disease, and renal failure in humans. Annals of Internal Medicine 78: 499\u2013508 (1973).","journal-title":"Annals of Internal Medicine"},{"key":"2010032_CR85","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/BF01059473","volume":"3","author":"E.J. Triggs","year":"1975","unstructured":"Triggs, E.J. and Nation, R.L.: Pharmacokinetics in the aged: A review. Journal of Pharmacokinetics and Biopharmaceutics 3: 387\u2013418 (1975).","journal-title":"Journal of Pharmacokinetics and Biopharmaceutics"},{"key":"2010032_CR86","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1097\/00000542-197009000-00002","volume":"33","author":"G.T. Tucker","year":"1970","unstructured":"Tucker, G.T.; Bayer, R.M.; Bridenbaugh, P.O. and Moore, D.C.: Binding of anilide-type local anesthetics in human plasma. Anesthesiology 33: 287\u2013303 (1970).","journal-title":"Anesthesiology"},{"key":"2010032_CR87","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/cpt1976203260","volume":"20","author":"C.T. Ueda","year":"1976","unstructured":"Ueda, C.T.; Williamson, B.J. and Dzinkzio, B.S.: Absolute quinidine bioavailability. Clinical Pharmacology and Therapeutics 20: 260\u2013265 (1976).","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"2010032_CR88","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/cpt1974165part1796","volume":"16","author":"H.F. Vohringer","year":"1974","unstructured":"Vohringer, H.F. and Rietbrock, N.: Metabolism and excretion of digitoxin in man. Clinical Pharmacology and Therapeutics 16: 796\u2013806 (1974).","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"2010032_CR89","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1172\/JCI103518","volume":"36","author":"W.J. Waddell","year":"1957","unstructured":"Waddell, W.J. and Butler, T.C.: The distribution of phenobarbital. Journal of Clinical Investigation 36: 1217\u20131226 (1957).","journal-title":"Journal of Clinical Investigation"},{"key":"2010032_CR90","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/BF00606560","volume":"9","author":"S. Wallace","year":"1976","unstructured":"Wallace, S. and Brodie, M.J.: Decreased drug binding in serum from patients with chronic hepatic disease. European Journal of Clinical Pharmacology 9: 429\u2013432 (1976).","journal-title":"European Journal of Clinical Pharmacology"},{"key":"2010032_CR91","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/cpt1975184377","volume":"18","author":"G.R. Wilkinson","year":"1975","unstructured":"Wilkinson, G.R. and Shand, D.G.: A physiological approach to hepatic drug clearance. Clinical Pharmacology and Therapeutics 18: 377\u2013390 (1975).","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"2010032_CR92","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3109\/03602537508993754","volume":"4","author":"G.R. Wilkinson","year":"1975","unstructured":"Wilkinson, G.R. and Schenker, S.: Drug disposition and liver disease. Drug Metabolism Reviews 4: 139\u2013175 (1975).","journal-title":"Drug Metabolism Reviews"},{"key":"2010032_CR93","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/cpt197620190","volume":"20","author":"R.L. Williams","year":"1976","unstructured":"Williams, R.L.; Schary, W.L.; Blaschke, T.F.; Meffin, P.J.; Melmon, K.L. and Rowland, M.: Influence of acute viral hepatitis on disposition and pharmacologic effect of warfarin. Clinical Pharmacology and Therapeutics 20: 90\u201397 (1976).","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"2010032_CR94","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/cpt1976203290","volume":"20","author":"R.L. Williams","year":"1976","unstructured":"Williams, R.L.; Blaschke, T.F.; Meffin, P.J.; Melmon, K.L. and Rowland, M.: Influence of viral hepatitis on the disposition of two compounds with high hepatic clearance: ligocaine and indocyanine green. Clinical Pharmacology and Therapeutics 20: 290\u2013299 (1976b).","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"2010032_CR95","first-page":"141A","volume":"24","author":"R.L. Williams","year":"1976","unstructured":"Williams, R.L.; Blaschke, T.F.; Meffin, P.J.; Melmon, K.L. and Rowland, M.: Influence of acute viral hepatitis on disposition and plasma binding of tolbutamide (Abstract). Clinical Research 24: 141A (1976c).","journal-title":"Clinical Research"},{"key":"2010032_CR96","first-page":"259A","volume":"24","author":"R.L. Williams","year":"1976","unstructured":"Williams, R.L.; Blaschke, T.F.; Meffin, P.J.; Melmon, K.L. and Rowland, M.: Antipyrine and indocyanine green as indicators of drug disposition during acute viral hepatitis (Abstract). Clinical Research 24: 259A (1976d).","journal-title":"Clinical Research"},{"key":"2010032_CR97","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/0041-008X(71)90006-8","volume":"19","author":"R.L. Wolen","year":"1971","unstructured":"Wolen, R.L.; Gruber, C.M.; Kiplinger, G.F. and Scholz, N.E.: Concentration of propoxyphene in human plasma following oral, intramuscular and intravenous administration. Toxicology and Applied Pharmacology 19: 480\u2013492 (1971).","journal-title":"Toxicology and Applied Pharmacology"},{"key":"2010032_CR98","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/cpt1976195part1552","volume":"19","author":"A. Yacobi","year":"1976","unstructured":"Yacobi, A.; Udall, J.A. and Levy, G.: Serum protein binding as a determinant of warfarin body clearance and anticoagulant effect. Clinical Pharmacology and Therapeutics 19: 552\u2013558 (1976).","journal-title":"Clinical Pharmacology and Therapeutics"}],"container-title":["Clinical Pharmacokinetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.2165\/00003088-197702010-00003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T01:43:09Z","timestamp":1708393389000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.2165\/00003088-197702010-00003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,2]]},"references-count":98,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1977,2]]}},"alternative-id":["2010032"],"URL":"https:\/\/doi.org\/10.2165\/00003088-197702010-00003","relation":{},"ISSN":["0312-5963","1179-1926"],"issn-type":[{"value":"0312-5963","type":"print"},{"value":"1179-1926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,2]]}}}