{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:42:59Z","timestamp":1790718179305,"version":"4.1.0"},"reference-count":64,"publisher":"IWA Publishing","issue":"1","content-domain":{"domain":["iwaponline.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,3,1]]},"abstract":"<jats:p>Disinfection by-products are contaminants produced during drinking water disinfection. Several DBPs have been implicated in a variety of toxic effects, mainly carcinogenic and genotoxic effects. Moreover, DBPs exposure has also been associated with an increased risk of developmental effects. In this study, the developmental toxicity and genotoxicity of 10 DBPs (four trihalomethanes [THMs], five haloacetic acids [HAAs] and sodium bromate) in the zebrafish embryo model were evaluated. Embryos exposed for 72 hours were observed for different endpoints such as growth, hatching success, malformations and lethality. THMs exposure resulted in adverse developmental effects and a significant reduced tail length. Two HAAs, tribromoacetic acid and dichloroacetic acid, along with sodium bromate were found to cause a significant increase in malformation rate. Chloroform, chlorodibromomethane and sodium bromate produced a weak induction of DNA damage to whole embryos. However, developmental effects occurred at a range of concentrations (20\u2013100 \u03bcg\/mL) several orders of magnitude above the levels that can be attained in fetal blood in humans exposed to chlorinated water. In conclusion, the teratogenic and genotoxic activity observed by some DBPs in zebrafish reinforce the view that there is a weak capacity of disinfection products to cause developmental effects at environmentally relevant concentrations.<\/jats:p>","DOI":"10.2166\/wh.2014.006","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T13:06:40Z","timestamp":1425042400000},"page":"54-66","update-policy":"https:\/\/doi.org\/10.2166\/iwapcrossmarkpolicypage","source":"Crossref","is-referenced-by-count":49,"title":["Developmental effects and genotoxicity of 10 water disinfection by-products in zebrafish"],"prefix":"10.2166","volume":"13","author":[{"given":"Elisabet","family":"Teixid\u00f3","sequence":"first","affiliation":[{"name":"GRET-CERETOX and Toxicology Unit, Public Health Department, School of Pharmacy, University of Barcelona. Av. Joan XXIII s\/n, E-08028, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Piqu\u00e9","sequence":"first","affiliation":[{"name":"GRET-CERETOX and Toxicology Unit, Public Health Department, School of Pharmacy, University of Barcelona. Av. Joan XXIII s\/n, E-08028, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Gonzalez-Linares","sequence":"first","affiliation":[{"name":"GRET-CERETOX and Experimental Toxicology and Ecotoxicology Unit, Barcelona Science Park. Baldiri i Reixac 10-12, E-08028, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan M.","family":"Llobet","sequence":"first","affiliation":[{"name":"GRET-CERETOX and Toxicology Unit, Public Health Department, School of Pharmacy, University of Barcelona. Av. Joan XXIII s\/n, E-08028, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"G\u00f3mez-Catal\u00e1n","sequence":"first","affiliation":[{"name":"GRET-CERETOX and Toxicology Unit, Public Health Department, School of Pharmacy, University of Barcelona. Av. Joan XXIII s\/n, E-08028, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"945","published-online":{"date-parts":[[2014,5,29]]},"reference":[{"issue":"2","key":"2020032618315000900_JWH-D-14-00006C1","first-page":"302","article-title":"A method of computing the effectiveness of an insecticide","volume":"3","author":"Abbott","year":"1987","journal-title":"1925. J. Am. Mosq. 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