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The low antibiotic concentration in the water environment may promote the selection of antibiotic resistance. However, it is unclear how environmental factors affect resistance selection. We investigated the proliferation of quinolone-susceptible faecal bacteria (E. coli) exposed to low norfloxacin concentration (ng\/L) at variable temperatures, exposure times, and carbon concentrations, simulating the conditions of the water environment. The induction of antibiotic resistance in thirteen E. coli isolates was more likely to occur at 37 \u00b0C. However, resistance also occurred at temperatures as low as 25 \u00b0C, provided a longer exposure time of 5 days. These results suggest that antibiotic resistance is more likely to be induced in regions where temperatures may reach 25\u201337 \u00b0C, such as tropical regions.<\/jats:p>","DOI":"10.2166\/wh.2022.074","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T18:02:50Z","timestamp":1653933770000},"page":"1017-1026","update-policy":"https:\/\/doi.org\/10.2166\/iwapcrossmarkpolicypage","source":"Crossref","is-referenced-by-count":12,"title":["Potential impact factors on the enhancement of antibiotic resistance in a lake environment"],"prefix":"10.2166","volume":"20","author":[{"given":"S.","family":"Sorn","sequence":"first","affiliation":[{"name":"a Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2902-7309","authenticated-orcid":false,"family":"Sulfikar","sequence":"additional","affiliation":[{"name":"b Chemistry Department, Universitas Negeri Makassar, Makassar, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M-Y.","family":"Lin","sequence":"additional","affiliation":[{"name":"a Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Shuto","sequence":"additional","affiliation":[{"name":"a Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Noguchi","sequence":"additional","affiliation":[{"name":"c Department of Agriculture, Ibaraki University, Inashiki, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2577-9826","authenticated-orcid":false,"given":"R.","family":"Honda","sequence":"additional","affiliation":[{"name":"d Faculty of Geosciences and Civil Engineering, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Yamamoto-Ikemoto","sequence":"additional","affiliation":[{"name":"d Faculty of Geosciences and Civil Engineering, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Watanabe","sequence":"additional","affiliation":[{"name":"e Department of Food, Life and Environmental Sciences, Yamagata University, Tsuruoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"945","published-online":{"date-parts":[[2022,5,30]]},"reference":[{"key":"key-10.2166\/wh.2022.074-1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-018-3563-0"},{"key":"key-10.2166\/wh.2022.074-2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens8030118"},{"key":"key-10.2166\/wh.2022.074-3","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02603"},{"key":"key-10.2166\/wh.2022.074-4","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2017.01.041"},{"key":"key-10.2166\/wh.2022.074-5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2008.03745.x"},{"key":"key-10.2166\/wh.2022.074-6","doi-asserted-by":"publisher","DOI":"10.1038\/srep15043"},{"key":"key-10.2166\/wh.2022.074-7","volume-title":"M100-S24: Performance Standards for Antimicrobial Susceptibility Testing; 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