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Recently, ET has become one of the most serious alternative drugs of abuse in China. Therefore, an urgent need exists to develop a fast and convenient analysis method for monitoring ET. The current work presents a simple, fast, and sensitive direct injection method for the determination of ET and ETA in wastewater. After the optimization of the ultra-performance liquid chromatography\u2013tandem mass spectrometry and sample filtration conditions, the method exhibited satisfactory limits of detection (1 ng\/L) and good filtration loss. The validated method was successfully applied to determine the concentrations of ET and ETA in wastewater samples (n = 245) from several wastewater treatment plants in China. The concentrations of the targets in positive samples ranged from less than the lower limits of quantitation to 47.71 ng\/L. The method can meet ET monitoring and high-throughput analysis requirements.<\/jats:p>","DOI":"10.2166\/wh.2024.373","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T08:38:41Z","timestamp":1713429521000},"page":"887-895","update-policy":"https:\/\/doi.org\/10.2166\/iwapcrossmarkpolicypage","source":"Crossref","is-referenced-by-count":10,"title":["Direct injection ultra-performance liquid chromatography\u2013tandem mass spectrometry for the high-throughput determination of etomidate and etomidate acid in wastewater"],"prefix":"10.2166","volume":"22","author":[{"given":"Shuai","family":"Yuan","sequence":"first","affiliation":[{"name":"a Department of Forensic Toxicology, Academy of Forensic Science, Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Science Platform, Key Laboratory of Forensic Sciences, Ministry of Justice, Shanghai 200063, 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