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This study evaluated the effect of carbamazepine (CBZ) and diclofenac (DCF) on the behavior of seven EGSB (expanded granular sludge bed) anaerobic reactors at laboratory scale, using chromatographic and physicochemical analyses of the influent, effluent, and the biomass contained in the reactors. The results showed that CBZ had a greater effect on the removal and behavior of microorganisms than DCF, with average efficiencies of 34.04 \u00b1 18.58%, 20.76 \u00b1 8.51% and 16.29 \u00b1 11.08% during stage II, III and IV, respectively, for CBZ, and 92.37 \u00b1 12.74%, 26.77 \u00b1 5.90% and 22.28 \u00b1 9.60% during stage II, III and IV, respectively, for DCF. Additionally, it was found that the interaction of the co-substrate used (sodium acetate) in conjunction with the pharmaceutical compounds decreased the efficiency of the system in terms of the removal of analytes.<\/jats:p>","DOI":"10.2166\/wst.2022.054","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T12:19:51Z","timestamp":1645013991000},"page":"1620-1635","update-policy":"https:\/\/doi.org\/10.2166\/iwapcrossmarkpolicypage","source":"Crossref","is-referenced-by-count":3,"title":["Individual and synergic effect of carbamazepine and diclofenac in the removal of organic matter from an expanded granular bed anaerobic reactor"],"prefix":"10.2166","volume":"85","author":[{"given":"Eva Sandrith","family":"Baquero","sequence":"first","affiliation":[{"name":"Pollution Diagnostics and Control Group (GDCON), School of the Environment, Faculty of Engineering, University Research Campus (SIU), University of Antioquia (UdeA), Calle 70 No. 52-21, Medellin, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9310-6925","authenticated-orcid":false,"given":"Diana C.","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Pollution Diagnostics and Control Group (GDCON), School of the Environment, Faculty of Engineering, University Research Campus (SIU), University of Antioquia (UdeA), Calle 70 No. 52-21, Medellin, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3065-0285","authenticated-orcid":false,"given":"Gustavo A.","family":"Pe\u00f1uela","sequence":"additional","affiliation":[{"name":"Pollution Diagnostics and Control Group (GDCON), School of the Environment, Faculty of Engineering, University Research Campus (SIU), University of Antioquia (UdeA), Calle 70 No. 52-21, Medellin, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"945","published-online":{"date-parts":[[2022,2,16]]},"reference":[{"key":"key-10.2166\/wst.2022.054-1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rser.2011.11.017"},{"key":"key-10.2166\/wst.2022.054-2","volume-title":"Standard Methods for the Examination of Water and Wastewater","author":"American Public Health Association (APHA), American Water Works Association (AWWA), and Pollution Control Federation (WPCF).","year":"2017","edition":"23"},{"key":"key-10.2166\/wst.2022.054-3","doi-asserted-by":"publisher","DOI":"10.1016\/j.psep.2020.03.012"},{"key":"key-10.2166\/wst.2022.054-4","doi-asserted-by":"publisher","DOI":"10.1002\/etc.3339"},{"key":"key-10.2166\/wst.2022.054-5","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2014.03.022"},{"key":"key-10.2166\/wst.2022.054-6","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2016.02.047"},{"key":"key-10.2166\/wst.2022.054-7","first-page":"317","article-title":"Study of the occurrence and ecosystem danger of selected endocrine disruptors in the urban water cycle of the city of Bogot\u00e1, Colombia","volume":"53","author":"Bedoya-R\u00edos","year":"2018","journal-title":"Journal of Environmental Science and Health \u2013 Part A Toxic\/Hazardous Substances and Environmental Engineering"},{"key":"key-10.2166\/wst.2022.054-8","first-page":"293","article-title":"Mechanisms involved in the removal of emerging contaminants by a combined UASB-MBR system","volume":"179","author":"Bernal","year":"2018","journal-title":"WIT Transactions on The Built Environment"},{"key":"key-10.2166\/wst.2022.054-9","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2018.06.088"},{"key":"key-10.2166\/wst.2022.054-10","doi-asserted-by":"publisher","DOI":"10.1021\/es505521w"},{"key":"key-10.2166\/wst.2022.054-11","doi-asserted-by":"publisher","DOI":"10.1016\/j.psep.2018.06.019"},{"key":"key-10.2166\/wst.2022.054-12","volume-title":"Digesti\u00f3n anaerobia: una aproximaci\u00f3n a la tecnolog\u00eda. 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