{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T13:01:41Z","timestamp":1773493301990,"version":"3.50.1"},"reference-count":22,"publisher":"Japanese Society of Internal Medicine","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2023,3,15]]},"DOI":"10.2169\/internalmedicine.0076-22","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T22:11:50Z","timestamp":1660083110000},"page":"871-875","source":"Crossref","is-referenced-by-count":4,"title":["Successful Treatment of Granulomatous-lymphocytic Interstitial Lung Disease in a Patient with CTLA-4 Deficiency"],"prefix":"10.2169","volume":"62","author":[{"given":"Masashi","family":"Nishimura","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Miyata","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomomi","family":"Tanigaki","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakika","family":"Nomura","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Serizawa","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syunya","family":"Igarashi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koki","family":"Itou","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Ohno","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhei","family":"Kurata","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshifumi","family":"Kimizuka","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Fujikura","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujin","family":"Sekinaka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, National Defense Medical College, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanako","family":"Sekinaka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, National Defense Medical College, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Matsukuma","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, National Defense Medical College, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeaki","family":"Nonoyama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, National Defense Medical College, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Kawana","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Tam JS, Routes JM. Common variable immunodeficiency. Am J Rhinol Allergy 27: 260-265, 2013.","DOI":"10.2500\/ajra.2013.27.3899"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Torigian DA, Larosa DF, Levinson AI, Litzky LA, Miller WT. Granulomatous-lymphocytic interstitial lung disease associated with common variable immunodeficiency: CT findings. J Thorac Imaging 23: 162-169, 2008.","DOI":"10.1097\/RTI.0b013e318166d32f"},{"key":"3","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1365-2249.1994.tb06228.x","volume":"96","author":"AJ Stagg","year":"1994","unstructured":"3. Stagg AJ, Funauchi M, Knight SC, Webster AD, Farrant J. Failure in antigen responses by T cells from patients with common variable immunodeficiency (CVID). Clin Exp Immunol 96: 48-53, 1994.","journal-title":"Clinical & Experimental Immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0009-9104","issn-type":"print"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Hurst JR, Verma N, Lowe D, et al. British Lung Foundation\/United Kingdom Primary Immunodeficiency Network Consensus statement on the definition, diagnosis, and management of granulomatous-lymphocytic interstitial lung disease in common variable immunodeficiency disorders. J Allergy Clin Immunol Pract 5: 938-945, 2017.","DOI":"10.1016\/j.jaip.2017.01.021"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Park JH, Levinson AI. Granulomatous-lymphocytic interstitial lung disease (GLILD) in common variable immunodeficiency (CVID). Clin Immunol 134: 97-103.","DOI":"10.1016\/j.clim.2009.10.002"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Bogaert DJA, Dullaers M, Lambrecht BN, Vermaelen KY, De Baere E, Haerynck F. Genes associated with common variable immunodeficiency: one diagnosis to rule them all? J Med Genet 53: 575-590, 2016.","DOI":"10.1136\/jmedgenet-2015-103690"},{"key":"7","doi-asserted-by":"publisher","unstructured":"7. Verma N, Burns SO, Walker LSK, Sansom DM. Immune deficiency and autoimmunity in patients with CTLA-4 (CD152) mutations. Clin Exp Immunol 190: 1-7, 2017.","DOI":"10.1111\/cei.12997"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Cunningham-Rundles C. How I treat common variable immune deficiency. Blood 116: 7-15, 2010.","DOI":"10.1182\/blood-2010-01-254417"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Schubert D, Bode C, Kenefeck R, et al. Autosomal dominant immune dysregulation syndrome in humans with <i>CTLA4<\/i> mutations. Nat Med 20: 1410-1416, 2014.","DOI":"10.1038\/nm.3746"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Resnick ES, Moshier EL, Godbold JH, Cunningham-Rundles C. Morbidity and mortality in common variable immune deficiency over 4 decades. Blood 119: 1650-1657, 2012.","DOI":"10.1182\/blood-2011-09-377945"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Gambineri E, Perroni L, Passerini L, et al. Clinical and molecular profile of a new series of patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: inconsistent correlation between forkhead box protein 3 expression and disease severity. J Allergy Clin Immunol 122: 1105-1112.e1, 2008.","DOI":"10.1016\/j.jaci.2008.09.027"},{"key":"12","doi-asserted-by":"publisher","unstructured":"12. Price S, Shaw PA, Seitz A, et al. Natural history of autoimmune lymphoproliferative syndrome associated with <i>FAS<\/i> gene mutations. Blood 123: 1989-1999, 2014.","DOI":"10.1182\/blood-2013-10-535393"},{"key":"13","doi-asserted-by":"publisher","unstructured":"13. Chapel H, Lucas M, Lee M, et al. Common variable immunodeficiency disorders: division into distinct clinical phenotypes. Blood 112: 277-286, 2008.","DOI":"10.1182\/blood-2007-11-124545"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Rae W, Ward D, Mattocks C, et al. Clinical efficacy of a next-generation sequencing gene panel for primary immunodeficiency diagnostics. Clin Genet 93: 647-655.","DOI":"10.1111\/cge.13163"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Baumann U, Routes JM, Soler-Palac\u00edn P, Jolles S. The lung in primary immunodeficiencies: new concepts in infection and inflammation. Front Immunol 9: 1837, 2018.","DOI":"10.3389\/fimmu.2018.01837"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Maglione PJ, Overbey JR, Radigan L, Bagiella E, Cunningham-Rundles C. Pulmonary radiologic findings in common variable immunodeficiency: clinical and immunological correlations. Ann Allergy Asthma Immunol 113: 452-459, 2014.","DOI":"10.1016\/j.anai.2014.04.024"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Seow J, Graham C, Merrick B, et al. Longitudinal observation and decline of neutralizing antibody responses in the three months following SARS-CoV-2 infection in humans. Nat Microbiol 5: 1598-1607, 2020.","DOI":"10.1038\/s41564-020-00813-8"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Rao N, Mackinnon AC, Routes JM. Granulomatous and lymphocytic interstitial lung disease (GLILD): a spectrum of pulmonary histopathological lesions in common variable immunodeficiency (CVID) - histological and immunohistochemical analysis of 16 cases. Hum Pathol 46: 1306-1314, 2015.","DOI":"10.1016\/j.humpath.2015.05.011"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Hasegawa M, Sakai F, Okabayashi A, et al. Intravenous immunoglobulin monotherapy for granulomatous lymphocytic interstitial lung disease in common variable immunodeficiency. Intern Med 56: 2899-2902, 2017.","DOI":"10.2169\/internalmedicine.7757-16"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Lamers OAC, Smits BM, Leavis HL, et al. Treatment strategies for GLILD in common variable immunodeficiency: a systematic review. Front Immunol 12: 606099, 2021.","DOI":"10.3389\/fimmu.2021.606099"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Boujaoude Z, Arya R, Rafferty W, Dammert P. Organising pneumonia in common variable immunodeficiency. BMJ Case Rep 2013: bcr2013008905, 2013.","DOI":"10.1136\/bcr-2013-008905"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Kohler PF, Cook RD, Brown WR, Manguso RL. Common variable hypogammaglobulinemia with T-cell nodular lymphoid interstitial pneumonitis and B-cell nodular lymphoid hyperplasia: different lymphocyte populations with a similar response to prednisone therapy. J Allergy Clin Immunol 70: 299-305, 1982.","DOI":"10.1016\/0091-6749(82)90066-5"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/62\/6\/62_0076-22\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,18]],"date-time":"2023-03-18T03:22:26Z","timestamp":1679109746000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/62\/6\/62_0076-22\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,15]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.0076-22","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,15]]},"article-number":"0076-22"}}