{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:34:36Z","timestamp":1790030076212,"version":"4.0.1"},"reference-count":15,"publisher":"Japanese Society of Internal Medicine","issue":"22","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2022,11,15]]},"DOI":"10.2169\/internalmedicine.0257-22","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T22:09:34Z","timestamp":1662415774000},"page":"3449-3452","source":"Crossref","is-referenced-by-count":16,"title":["New-onset Seropositive Rheumatoid Arthritis Following COVID-19 Vaccination in a Patient with Seronegative Status"],"prefix":"10.2169","volume":"61","author":[{"given":"Haruka","family":"Yonezawa","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Seirei Hamamatsu General Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-ichiro","family":"Ohmura","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Seirei Hamamatsu General Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Ohkubo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Seirei Hamamatsu General Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Seirei Hamamatsu General Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Polack FP, Thomas SJ, Kitchin N, et al.; the C4591001 Clinical Trial Group. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N Engl J Med 383: 2603-2615, 2020.","DOI":"10.1056\/NEJMoa2034577"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Baden LR, El Sahly HM, Essink B, et al.; the COVE Study Group. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N Engl J Med 384: 403-416, 2021.","DOI":"10.1056\/NEJMoa2035389"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Galeotti C, Bayry J. Autoimmune and inflammatory diseases following COVID-19. Nat Rev Rheumatol 16: 413-414, 2020.","DOI":"10.1038\/s41584-020-0448-7"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Chen Y, Xu Z, Wang P, et al. New-onset autoimmune phenomena post-COVID-19 vaccination. Immunology 165: 386-401, 2022.","DOI":"10.1111\/imm.13443"},{"key":"5","unstructured":"5. Aletaha D, Neogi T, Silman AJ, et al. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative. Ann Rheum Dis 69: 1580-1588, 2010."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Teijaro JR, Farber DL. COVID-19 vaccines: modes of immune activation and future challenges. Nat Rev Immunol 21: 195-197, 2021.","DOI":"10.1038\/s41577-021-00526-x"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Reinke S, Thakur A, Gartlan C, Bezbradica JS, Milicic A. Inflammasome-mediated immunogenicity of clinical and experimental vaccine adjuvants. Vaccines (Basel) 8: 554, 2020.","DOI":"10.3390\/vaccines8030554"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Guarda G, Zenger M, Yazdi AS, et al. Differential expression of NLRP3 among hematopoietic cells. J Immunol 186: 2529-2534, 2011.","DOI":"10.4049\/jimmunol.1002720"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Dupaul-Chicoine J, Arabzadeh A, Dagenais M, et al. The Nlrp3 inflammasome suppresses colorectal cancer metastatic growth in the liver by promoting natural killer cell tumoricidal activity. Immunity 43: 751-763, 2015.","DOI":"10.1016\/j.immuni.2015.08.013"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Ghiringhelli F, Apetoh L, Tesniere A, et al. Activation of the NLRP3 inflammasome in dendritic cells induces IL-1\u03b2-dependent adaptive immunity against tumors. Nat Med 15: 1170-1178, 2009.","DOI":"10.1038\/nm.2028"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Li Z, Guo J, Bi L. Role of the NLRP3 inflammasome in autoimmune diseases. Biomed Pharmacother 130: 110542, 2020.","DOI":"10.1016\/j.biopha.2020.110542"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Pelka K, Shibata T, Miyake K, Latz E. Nucleic acid-sensing TLRs and autoimmunity: novel insights from structural and cell biology. Immunol Rev 269: 60-75, 2016.","DOI":"10.1111\/imr.12375"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Liao KP, Alfredsson L, Karlson EW. Environmental influences on risk for rheumatoid arthritis. Curr Opin Rheumatol 21: 279-283, 2009.","DOI":"10.1097\/BOR.0b013e32832a2e16"},{"key":"14","unstructured":"14. Vaccines and Related Biological Products Advisory Committee Meeting FDA Briefing Document Moderna COVID-19 Vaccine. 2020 [Internet]. [cited 2020 Dec 17]. Available from: https:\/\/www.fda.gov\/media\/144434\/download"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Li X, Tong X, Yeung WWY, et al. Two-dose COVID-19 vaccination and possible arthritis flare among patients with rheumatoid arthritis in Hong Kong. Ann Rheum Dis 81: 564-568, 2022.","DOI":"10.1136\/annrheumdis-2021-221571"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/61\/22\/61_0257-22\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T03:20:30Z","timestamp":1668828030000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/61\/22\/61_0257-22\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,15]]},"references-count":15,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.0257-22","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,15]]},"article-number":"0257-22"}}