{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:42:08Z","timestamp":1790959328738,"version":"4.1.0"},"reference-count":30,"publisher":"Japanese Society of Internal Medicine","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2023,10,1]]},"DOI":"10.2169\/internalmedicine.0912-22","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T22:11:58Z","timestamp":1677017518000},"page":"2813-2820","source":"Crossref","is-referenced-by-count":6,"title":["Association between Living Conditions and the Risk Factors, Etiology, and Outcome of Ischemic Stroke in Young Adults"],"prefix":"10.2169","volume":"62","author":[{"given":"Yu","family":"Kono","sequence":"first","affiliation":[{"name":"Department of Neurology, Fuji City General Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Terasawa","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Jikei University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichiro","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Jikei University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Iguchi","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Jikei University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nippon Medical School, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikako","family":"Nito","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nippon Medical School, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Suda","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nippon Medical School, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nippon Medical School, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, Toho University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Kanzawa","sequence":"additional","affiliation":[{"name":"Department of Stroke Medicine, Institute of Brain and Blood Vessels, Mihara Memorial Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Yamashiro","sequence":"additional","affiliation":[{"name":"Department of Neurology, Juntendo University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Stroke Center and Division of Neurology, Department of Medicine, Jichi Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Okubo","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Medicine, NTT Medical Center Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","unstructured":"1. GBD 2016 Stroke Collaborators. Global, regional, and national burden of stroke, 1990-2016: a systematic analysis for the Global Burden of Disease Study. Lancet Neurol 18: 439-458, 2019."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Ekker MS, Boot EM, Singhal AB, et al. Epidemiology, aetiology, and management of ischaemic stroke in young adults. Lancet Neurol 17: 790-801, 2018.","DOI":"10.1016\/S1474-4422(18)30233-3"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Kono Y, Terasawa Y, Sakai K, et al. Risk factors, etiology, and outcome of ischemic stroke in young adults: a Japanese multicenter prospective study. J Neurol Sci 417: 117068, 2020","DOI":"10.1016\/j.jns.2020.117068"},{"key":"4","unstructured":"4. OECD 2021 [Internet]. [cited 2021 Nov 24]. Available from: https:\/\/www.oecd.org"},{"key":"5","unstructured":"5. National Institute of Population and Social Security Research [Internet]. [cited 2021 Nov 24]. Available from: https:\/\/www.ipss.go.jp\/index-e.asp"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Andersen KK, Olsen TS. Married, unmarried, divorced, and widowed and the risk of stroke. Acta Neurol Scand 138: 41-46, 2018.","DOI":"10.1111\/ane.12914"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Waje-Andreassen U, Naess H, Thomassen L, Eide GE, Vedeler CA. Long-term mortality among young ischemic stroke patients in western Norway. Acta Neurol Scand 116: 150-156, 2007.","DOI":"10.1111\/j.1600-0404.2007.00822.x"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Aron AW, Staff I, Fortunato G, McCullough LD. Prestroke living situation and depression contribute to initial stroke severity and stroke recovery. J Stroke Cerebrovasc Dis 24: 492-499, 2015.","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.09.024"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Rendall MS, Weden MM, Favreault MM, Waldron H. The protective effect of marriage for survival: a review and update. Demography 48: 481-506, 2011.","DOI":"10.1007\/s13524-011-0032-5"},{"key":"10","unstructured":"10. Ministry of Health, Labour and Welfare of Japan, Comprehensive Survey of Living Conditions [Internet]. [cited 2021 Nov 24]. Available from: https:\/\/www.mhlw.go.jp\/english\/database\/db-hss\/cslc-tables.html"},{"key":"11","unstructured":"11. National Institute of Health and Nutrition. Section of the National Health and Nutrition Survey [Internet]. [cited 2021 Nov 24]. Available from: https:\/\/www.nibiohn.go.jp\/eiken\/english\/research\/project_nhns.html"},{"key":"12","doi-asserted-by":"publisher","unstructured":"12. Adams HP Jr, Bendixen BH, Kappelle LJ, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 24: 35-41, 1993.","DOI":"10.1161\/01.STR.24.1.35"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Hart RG, Diener HC, Coutts SB, et al; the Cytogenic Stroke\/ESUS International Working Group. Embolic strokes of undetermined source: the case for a new clinical construct. Lancet Neurol 13: 429-438, 2014.","DOI":"10.1016\/S1474-4422(13)70310-7"},{"key":"14","doi-asserted-by":"publisher","unstructured":"14. Aigner A, Grittner U, Rolfs A, Norrving B, Siegerink B, Busch MA. Contribution of established stroke risk factors to the burden of stroke in young adults. Stroke 48: 1744-1751, 2017.","DOI":"10.1161\/STROKEAHA.117.016599"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Boden-Albala B, Litwak E, Elkind MS, Rundek T, Sacco RL. Social isolation and outcomes post stroke. Neurology 64: 1888-1892, 3005.","DOI":"10.1212\/01.WNL.0000163510.79351.AF"},{"key":"16","doi-asserted-by":"publisher","unstructured":"16. Reeves MJ, Prager M, Fang J, Stamplecoski M, Kapral MK. Impact of living alone on the care and outcomes of patients with acute stroke. Stroke 45: 3083-3085, 2014.","DOI":"10.1161\/STROKEAHA.114.006520"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Redfors P, Isaks\u00e9n D, Lappas G, et al. Living alone predicts mortality in patients with ischemic stroke before 70 years of age: a long-term prospective follow-up study. BMC Neurol 16: 80, 2016.","DOI":"10.1186\/s12883-016-0599-y"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Raymo JM. Living alone in Japan: relationships with happiness and health. Demogr Res 32: 1267-1298, 2015.","DOI":"10.4054\/DemRes.2015.32.46"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Maselko J, Bates LM, Avenda\u00f1o M, Glymour MM. The intersection of sex, marital status, and cardiovascular risk factors in shaping stroke incidence: results from the health and retirement study. J Am Geriatr Soc 57: 2293-2299, 2009.","DOI":"10.1111\/j.1532-5415.2009.02555.x"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Hanna KL, Collins PF. Relationship between living alone and food and nutrient intake. Nutr Rev 73: 594-611, 2015.","DOI":"10.1093\/nutrit\/nuv024"},{"key":"21","doi-asserted-by":"publisher","unstructured":"21. Tani Y, Kondo N, Takagi D, et al. Combined effects of eating alone and living alone on unhealthy dietary behaviors, obesity and underweight in older Japanese adults: results of the JAGES. Appetite 95: 1-8, 2015.","DOI":"10.1016\/j.appet.2015.06.005"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Bailey RR, Phad A, McGrath R, et al. Prevalence of five lifestyle risk factors among U.S. adults with and without stroke. Disabil Health J 12: 323-327, 2019.","DOI":"10.1016\/j.dhjo.2018.11.003"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Jacob L, Haro JM, Koyanagi A. Relationship between living alone and common mental disorders in the 1993, 2000 and 2007 National Psychiatric Morbidity Surveys. PLoS One 14: e0215182, 2019.","DOI":"10.1371\/journal.pone.0215182"},{"key":"24","doi-asserted-by":"publisher","unstructured":"24. Hakulinen C, Pulkki-R\u00e5back L, Virtanen M, Jokela M, Kivim\u00e4ki M. Social isolation and loneliness as risk factors for myocardial infarction, stroke and mortality: UK Biobank cohort study of 479 054 men and women. Heart 104: 1536-1542, 2018.","DOI":"10.1136\/heartjnl-2017-312663"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Valtorta NK, Kanaan M, Gilbody S, Ronzi S, Hanratty B. Loneliness and social isolation as risk factors for coronary heart disease and stroke: systematic review and meta-analysis of longitudinal observational studies. Heart 102: 1009-1016, 2016.","DOI":"10.1136\/heartjnl-2015-308790"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Nagayoshi M, Everson-Rose SA, Iso H, Mosley TH, Rose KM, Lutsey PL. Social network, social support, and risk of incident stroke: Atherosclerosis Risk in Communities study. Stroke 45: 2868-2673, 2014.","DOI":"10.1161\/STROKEAHA.114.005815"},{"key":"27","unstructured":"27. Scheurer D, Choudhry N, Swanton KA, Maltin O, Shrank W. Association between different types of social support and medication adherence. Am J Manag Care 18: e461-e467, 2012."},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Loucks EB, Sullivan LM, D&apos;Agostino RB Sr, Larson MG, Berkman LF, Benjamin EJ. Social networks and inflammatory markers in the Framingham Heart Study. J Biosoc Sci 38: 835-842, 2006.","DOI":"10.1017\/S0021932005001203"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Venna VR, McCullough LD. Role of social factors on cell death, cerebral plasticity and recovery after stroke. Metab Brain Dis 30: 497-506, 2015.","DOI":"10.1007\/s11011-014-9544-1"},{"key":"30","doi-asserted-by":"publisher","unstructured":"30. Rolfs A, Fazekas F, Grittner U, et al.; Stroke in Young Fabry Patients (sifap) Investigators. Acute cerebrovascular disease in the young: the Stroke in Young Fabry Patients study. Stroke 44: 340-349, 2013.","DOI":"10.1161\/STROKEAHA.112.663708"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/62\/19\/62_0912-22\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T03:25:57Z","timestamp":1696649157000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/62\/19\/62_0912-22\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,1]]},"references-count":30,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.0912-22","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,1]]},"article-number":"0912-22"}}