{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:01:01Z","timestamp":1792735261021,"version":"4.5.0"},"reference-count":30,"publisher":"Japanese Society of Internal Medicine","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2019,1,1]]},"DOI":"10.2169\/internalmedicine.1431-18","type":"journal-article","created":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T22:50:24Z","timestamp":1533855024000},"page":"135-139","source":"Crossref","is-referenced-by-count":15,"title":["Intravenous Cyclophosphamide for Gastric Antral Vascular Ectasia Associated with Systemic Sclerosis Refractory to Endoscopic Treatment: A Case Report and Review of the Pertinent Literature"],"prefix":"10.2169","volume":"58","author":[{"given":"Yuki","family":"Matsumoto","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Tokyo Medical University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haeru","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Tokyo Medical University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Tahara","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Tokyo Medical University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Tokyo Medical University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoko","family":"Tsubouchi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Tokyo Medical University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Tokyo Medical University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Mizuuchi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Tokyo Medical University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Tokyo Medical University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuji","family":"Sawada","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Tokyo Medical University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/S0016-5085(84)80080-3","volume":"87","author":"M Jabbari","year":"1984","unstructured":"1. Jabbari M, Cherry R, Lough JO, Daly DS, Kinnear DG, Goresky CA. Gastric antral vascular ectasia: the watermelon stomach. Gastroenterology 87: 1165-1170, 1984.","journal-title":"Gastroenterology","ISSN":"https:\/\/id.crossref.org\/issn\/0016-5085","issn-type":"print"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Lee FI, Costello F, Flanagan N, Vasudev KS. Diffuse antral vascular ectasia. Gastrointest Endosc 30: 87-90, 1984.","DOI":"10.1016\/S0016-5107(84)72326-1"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Ito M, Uchida Y, Kamano S, Kawabata H, Nishioka M. Clinical comparisons between two subsets of gastric antral vascular ectasia. Gastrointest Endosc 53: 764-770, 2001.","DOI":"10.1067\/mge.2001.113922"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Zepeda-Gomez S. Endoscopic treatment for gastric antral vascular ectasia: current options. GE Port J Gastroenterol 24: 176-182, 2017.","DOI":"10.1159\/000453271"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Patwardhan VR, Cardenas A. Review article: the management of portal hypertensive gastropathy and gastric antral vascular ectasia in cirrhosis. Aliment Pharmacol Ther 40: 354-362, 2014.","DOI":"10.1111\/apt.12824"},{"key":"6","unstructured":"6. Kruger R, Ryan ME, Dickson KB, Nunez JF. Diffuse vascular ectasia of the gastric antrum. Am J Gastroenterol 82: 421-426, 1987."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Nagaraja V, McMahan ZH, Getzug T, Khanna D. Management of gastrointestinal involvement in scleroderma. Curr Treatment Options Rheumatol 1: 82-105, 2015.","DOI":"10.1007\/s40674-014-0005-0"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Gyger G, Baron M. Gastrointestinal manifestations of scleroderma: recent progress in evaluation, pathogenesis, and management. Curr Rheumatol Rep 14: 22-29, 2012.","DOI":"10.1007\/s11926-011-0217-3"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Marie I, Ducrotte P, Antonietti M, Herve S, Levesque H. Watermelon stomach in systemic sclerosis: its incidence and management. Aliment Pharmacol Ther 28: 412-421, 2008.","DOI":"10.1111\/j.1365-2036.2008.03739.x"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Ghrenassia E, Avouac J, Khanna D, et al. Prevalence, correlates and outcomes of gastric antral vascular ectasia in systemic sclerosis: a EUSTAR case-control study. J Rheumatol 41: 99-105, 2014.","DOI":"10.3899\/jrheum.130386"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Hung EW, Mayes MD, Sharif R, et al. Gastric antral vascular ectasia and its clinical correlates in patients with early diffuse systemic sclerosis in the SCOT trial. J Rheumatol 40: 455-460, 2013.","DOI":"10.3899\/jrheum.121087"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Ceribelli A, Cavazzana I, Airo P, Franceschini F. Anti-RNA polymerase III antibodies as a risk marker for early gastric antral vascular ectasia (GAVE) in systemic sclerosis. J Rheumatol 37: 1544, 2010.","DOI":"10.3899\/jrheum.100124"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Ingraham KM, O&apos;Brien MS, Shenin M, Derk CT, Steen VD. Gastric antral vascular ectasia in systemic sclerosis: demographics and disease predictors. J Rheumatol 37: 603-607, 2010.","DOI":"10.3899\/jrheum.090600"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Fujishiro M, Iguchi M, Kakushima N, et al. Guidelines for endoscopic management of non-variceal upper gastrointestinal bleeding. Dig Endosc 28: 363-378, 2016.","DOI":"10.1111\/den.12639"},{"key":"15","doi-asserted-by":"publisher","unstructured":"15. Yusoff I, Brennan F, Ormonde D, Laurence B. Argon plasma coagulation for treatment of watermelon stomach. Endoscopy 34: 407-410, 2002.","DOI":"10.1055\/s-2002-25287"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Probst A, Scheubel R, Wienbeck M. Treatment of watermelon stomach (GAVE syndrome) by means of endoscopic argon plasma coagulation (APC): long-term outcome. Z Gastroenterol 39: 447-452, 2001.","DOI":"10.1055\/s-2001-15722"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Kwan V, Bourke MJ, Williams SJ, et al. Argon plasma coagulation in the management of symptomatic gastrointestinal vascular lesions: experience in 100 consecutive patients with long-term follow-up. Am J Gastroenterol 101: 58-63, 2006.","DOI":"10.1111\/j.1572-0241.2006.00370.x"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Azam J, Caperon A, Lawson CA, Gough A. Medical versus laser therapy for gastric antral vascular ectasia: comment on the clinical images by Thonhofer et al. Arthritis Rheum 62: 3517; author reply 3517-3518, 2010.","DOI":"10.1002\/art.27681"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Lorenzi AR, Johnson AH, Davies G, Gough A. Gastric antral vascular ectasia in systemic sclerosis: complete resolution with methylprednisolone and cyclophosphamide. Ann Rheum Dis 60: 796-798, 2001.","DOI":"10.1136\/ard.60.8.796"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Schulz SW, O&apos;Brien M, Maqsood M, Sandorfi N, Del Galdo F, Jimenez SA. Improvement of severe systemic sclerosis-associated gastric antral vascular ectasia following immunosuppressive treatment with intravenous cyclophosphamide. J Rheumatol 36: 1653-1656, 2009.","DOI":"10.3899\/jrheum.081247"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Papachristos DA, Nikpour M, Hair C, Stevens WM. Intravenous cyclophosphamide as a therapeutic option for severe refractory gastric antral vascular ectasia in systemic sclerosis. Intern Med J 45: 1077-1081, 2015.","DOI":"10.1111\/imj.12883"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Peterson A, Varga J. Cyclophosphamide: a novel treatment of gastric antral vascular ectasia associated with systemic sclerosis? Curr Rheumatol Rep 12: 4-7, 2010.","DOI":"10.1007\/s11926-009-0077-2"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Shibukawa G, Irisawa A, Sakamoto N, et al. Gastric antral vascular ectasia (GAVE) associated with systemic sclerosis: relapse after endoscopic treatment by argon plasma coagulation. Intern Med 46: 279-283, 2007.","DOI":"10.2169\/internalmedicine.46.6203"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Boltin D, Gingold-Belfer R, Lichtenstein L, Levi Z, Niv Y. Long-term treatment outcome of patients with gastric vascular ectasia treated with argon plasma coagulation. Eur J Gastroenterol Hepatol 26: 588-593, 2014.","DOI":"10.1097\/MEG.0000000000000047"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Fuccio L, Mussetto A, Laterza L, Eusebi LH, Bazzoli F. Diagnosis and management of gastric antral vascular ectasia. World J Gastrointest Endosc 5: 6-13, 2013.","DOI":"10.4253\/wjge.v5.i1.6"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Manetti M, Neumann E, Milia AF, et al. Severe fibrosis and increased expression of fibrogenic cytokines in the gastric wall of systemic sclerosis patients. Arthritis Rheum 56: 3442-3447, 2007.","DOI":"10.1002\/art.22940"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Manetti M, Neumann E, Muller A, et al. Endothelial\/lymphocyte activation leads to prominent CD4+ T cell infiltration in the gastric mucosa of patients with systemic sclerosis. Arthritis Rheum 58: 2866-2873, 2008.","DOI":"10.1002\/art.23806"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Bhattacharyya A, Sahhar J, Milliken S, et al. Autologous hematopoietic stem cell transplant for systemic sclerosis improves anemia from gastric antral vascular ectasia. J Rheumatol 42: 554-555, 2015.","DOI":"10.3899\/jrheum.141234"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Kar P, Mitra S, Resnick JM, Torbey CF. Gastric antral vascular ectasia: case report and review of the literature. Clin Med Res 11: 80-85, 2013.","DOI":"10.3121\/cmr.2012.1036"},{"key":"30","unstructured":"30. Schoonbroodt D, Horsmans Y, Hoang P, Poncelet-Maton E, Laka A, Geubel A. [Vascular gastric anomalies, CREST syndrome and primary biliary cirrhosis: efficacy of ethinyl estradiol-norethisterone combination]. Gastroenterol Clin Biol 18: 649-651, 1994 (in French, Abstract in English)."}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/58\/1\/58_1431-18\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T14:33:27Z","timestamp":1604759607000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/58\/1\/58_1431-18\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.1431-18","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,1]]}}}