{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:21:14Z","timestamp":1780050074742,"version":"3.53.1"},"reference-count":12,"publisher":"Japanese Society of Internal Medicine","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2024,1,1]]},"DOI":"10.2169\/internalmedicine.1845-23","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T07:43:58Z","timestamp":1683704638000},"page":"63-70","source":"Crossref","is-referenced-by-count":2,"title":["Comprehensive Cancer Genomic Profiling of Liver Metastasis Led to the Unexpected Identification of Colorectal Cancer"],"prefix":"10.2169","volume":"63","author":[{"given":"Hideaki","family":"Miyamoto","sequence":"first","affiliation":[{"name":"Cancer Genome Center, Kumamoto University Hospital, Japan"},{"name":"Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumi","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Cancer Genome Center, Kumamoto University Hospital, Japan"},{"name":"Department of Diagnostic Pathology, Kumamoto University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakiko","family":"Abe","sequence":"additional","affiliation":[{"name":"Genetic Counseling Department, Kumamoto University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Sugita","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kumamoto Regional Medical Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Matsui","sequence":"additional","affiliation":[{"name":"Cancer Genome Center, Kumamoto University Hospital, Japan"},{"name":"Department of Molecular Laboratory Medicine, Faculty of Life Sciences, Kumamoto University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Kohno T, Kato M, Kohsaka S, et al. C-CAT: the national datacenter for cancer genomic medicine in Japan. Cancer Discov 12: 2509-2515, 2022.","DOI":"10.1158\/2159-8290.CD-22-0417"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Sunami K, Naito Y, Komine K, et al. Chronological improvement in precision oncology implementation in Japan. Cancer Sci 113: 3995-4000, 2022.","DOI":"10.1111\/cas.15517"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Takeda M, Takahama T, Sakai K, et al. Clinical application of the FoundationOne CDx assay to therapeutic decision-making for patients with advanced solid tumors. Oncologist 26: e588-e596, 2021.","DOI":"10.1002\/onco.13639"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Tate JG, Bamford S, Jubb HC, et al. COSMIC: the catalogue of somatic mutations in cancer. Nucleic Acids Res 47: D941-D947, 2019.","DOI":"10.1093\/nar\/gky1015"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Landrum MJ, Chitipiralla S, Brown GR, et al. ClinVar: improvements to accessing data. Nucleic Acids Res 48: D835-D844, 2020.","DOI":"10.1093\/nar\/gkz972"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Wardell CP, Fujita M, Yamada T, et al. Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations. J Hepatol 68: 959-969, 2018.","DOI":"10.1016\/j.jhep.2018.01.009"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Jusakul A, Cutcutache I, Yong CH, et al. Whole-genome and epigenomic landscapes of etiologically distinct subtypes of cholangiocarcinoma. Cancer Discov 7: 1116-1135, 2017.","DOI":"10.1158\/2159-8290.CD-17-0368"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Gouda P, Kay R, Habib M, Aziz A, Aziza E, Welsh R. Clinical features and complications of Loeys-Dietz syndrome: a systematic review. Int J Cardiol 362: 158-167, 2022.","DOI":"10.1016\/j.ijcard.2022.05.065"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Sunami K, Ichikawa H, Kubo T, et al. Feasibility and utility of a panel testing for 114 cancer-associated genes in a clinical setting: a hospital-based study. Cancer Sci 110: 1480-1490, 2019.","DOI":"10.1111\/cas.13969"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Ebi H, Bando H. Precision oncology and the universal health coverage system in Japan. JCO Precis Oncol 3: PO.19.00291, 2019.","DOI":"10.1200\/PO.19.00291"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Ross JS, Sokol ES, Moch H, et al. Comprehensive genomic profiling of carcinoma of unknown primary origin: retrospective molecular classification considering the CUPISCO study design. Oncologist 26: e394-e402, 2021.","DOI":"10.1002\/onco.13597"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Yu B, Wang Q, Liu X, et al. Case report: molecular profiling assists in the diagnosis and treatment of cancer of unknown primary. Front Oncol 12: 723140, 2022.","DOI":"10.3389\/fonc.2022.723140"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/63\/1\/63_1845-23\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T04:30:27Z","timestamp":1715574627000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/63\/1\/63_1845-23\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.1845-23","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,1]]},"article-number":"1845-23"}}