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Tooth loss is associated with accelerated cognitive decline and volumetric brain differences: a population-based study. Neurobiol Aging 67: 23-30, 2018."},{"key":"10","unstructured":"10. Takeuchi K, Ohara T, Furuta M, et al. Tooth loss and risk of dementia in the community: the Hisayama study. J Am Geriatr Soc 65: e95-e100, 2017."},{"key":"11","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12877-018-0729-z","volume":"18","author":"B Oh","year":"2018","unstructured":"11. Oh B, Han D-H, Han K-T, et al. Association between residual teeth number in later life and incidence of dementia: a systematic review and meta-analysis. BMC Geriatrics 18: 48-56, 2018.","journal-title":"BMC Geriatrics","ISSN":"https:\/\/id.crossref.org\/issn\/1471-2318","issn-type":"print"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Al-Shammari KF, Al-Khabbaz AK, Al-Ansari JM, Neiva R, Wang HL. Risk indicators for tooth loss due to periodontal disease. 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