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Guilleminault C, Dement WC, Passouant P. Narcolepsy. Spectrum Publications, New York, 1976: 43-56."},{"key":"2","unstructured":"2. Roth B. Narcolepsy and hypersomnia: review and classification of 62 personally observed cases. Schweiz Arch Neurol Neurochir Psychiatr 119: 31-41, 1976."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Schuld A, Hebebrand J, Geller F, Pollm\u00e4cher T. Increased body mass index in patients with narcolepsy. Lancet 355: 1274-1275, 2000.","DOI":"10.1016\/S0140-6736(05)74704-8"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Schwartz AR, Patil SP, Laffan AM, Polotsky V, Schneider H, Smith PL. Obesity and obstructive sleep apnea. Proc Am Thorac Soc 15: 185-192, 2008.","DOI":"10.1513\/pats.200708-137MG"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Sansa G, Iranzo A, Santamaria J. Obstructive sleep apnea in narcolepsy. Sleep Med 11: 93-95, 2010.","DOI":"10.1016\/j.sleep.2009.02.009"},{"key":"6","unstructured":"6. Almeneessier AS, Almousa Y, Hammad O, et al. Long-term adherence to continuous positive airway pressure in patients with rapid eye movement-only obstructive sleep apnea: a prospective cohort study. J Thorac Dis 9: 3755-3765, 2017."},{"key":"7","unstructured":"7. Alzoubaidi M, Mokhlesi B. Obstructive sleep apnea during REM sleep: clinical relevance and therapeutic implications. Curr Opin Pulm Med 22: 545-554, 2016."},{"key":"8","doi-asserted-by":"publisher","unstructured":"8. Grimaldi D, Beccuti G, Touma C, Van Cauter E, Mokhlesi B. Association of obstructive sleep apnea in rapid eye movement sleep with reduced glycemic control in type 2 diabetes: therapeutic implication. Diabetes Care 37: 355-363, 2014.","DOI":"10.2337\/dc13-0933"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Hoshino T, Sasanabe R, Tanigawa T, et al. Effect of rapid eye movement-related obstructive sleep apnea on adherence to continuous positive airway pressure. 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Plazzi F, Tartarotti S, Poryazova R, Baumann CR, Bassetti CL. Sleep-disordered breathing and periodic limb movement in narcolepsy with cataplexy: a systematic analysis of 35 consecutive patients. Eur Neurol 70: 22-26, 2013."},{"key":"15","unstructured":"15. American Academy of Sleep Medicine. In: International Classification of Sleep Disorders, 2nd ed.: diagnostic and coding manual. American Academy of Sleep Medicine, Westchester, IL, 2005: 79-94."},{"key":"16","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/sleep\/28.1.113","volume":"28","author":"MR Littner","year":"2005","unstructured":"16. Littner MR, Kushida C, Wise M, et al. Practice parameters for clinical use of the multiple sleep latency test and the maintenance of wakefulness test. Sleep 28: 113-121, 2005.","journal-title":"SLEEP","ISSN":"https:\/\/id.crossref.org\/issn\/0161-8105","issn-type":"print"},{"key":"17","unstructured":"17. Berry RB, Brooks R, Gamaldo CE, et al. The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications. Version 2.1, 2014: 16-49."},{"key":"18","unstructured":"18. Haba-Rubio J, Janssens JP, Rochat T, Sforza E. Rapid eye movement-related disordered breathing: clinical and polysomnographic features. Chest 128: 3350-3357, 2005."},{"key":"19","unstructured":"19. Conwell W, Patel B, Doeing D, et al. Prevalence, clinical features, and CPAP adherence in REM-related sleep-disordered breathing: a cross-sectional analysis of a large clinical population. Sleep Breath 16: 519-526, 2012."},{"key":"20","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1093\/sleep\/9.4.519","volume":"9","author":"MA Carskadon","year":"1986","unstructured":"20. Carskadon MA. Guideline for the multiple sleep latency test (MSLT): a standard measure of sleepiness. 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