{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T17:40:15Z","timestamp":1781286015738,"version":"3.54.1"},"reference-count":21,"publisher":"Japanese Society of Internal Medicine","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2024,7,1]]},"DOI":"10.2169\/internalmedicine.2775-23","type":"journal-article","created":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T22:12:37Z","timestamp":1700431957000},"page":"1929-1932","source":"Crossref","is-referenced-by-count":4,"title":["Asymptomatic Acute Cerebral Infarction in a Patient with Hemoglobin K\u00f6ln"],"prefix":"10.2169","volume":"63","author":[{"given":"So","family":"Okubo","sequence":"first","affiliation":[{"name":"Department of Neurology, Tokyo Teishin Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taichi","family":"Tamagawa","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tokyo Teishin Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minako","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tokyo Teishin Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Bannai","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tokyo Teishin Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonari","family":"Seki","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tokyo Teishin Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Usuki","sequence":"additional","affiliation":[{"name":"Department of Hematology, NTT Medical Center Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Shiio","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tokyo Teishin Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Sabath DE. Molecular Diagnosis of Thalassemias and hemoglobinopathies: an ACLPS critical review. Am J Clin Pathol 148: 6-15, 2017.","DOI":"10.1093\/ajcp\/aqx047"},{"key":"2","doi-asserted-by":"publisher","unstructured":"2. Carrell RW, Lehmann H, Hutchison HE. Haemoglobin K\u00f6ln (\u03b2-98 valine\u2192methionine): an unstable protein causing inclusion-body anaemia. Nature 210: 915-916, 1966.","DOI":"10.1038\/210915a0"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Horst J, Oehme R, Kohne E. Hemoglobin K\u00f6ln: direct analysis of the gene mutation by synthetic DNA probes. Blood 68: 1175-1177, 1986.","DOI":"10.1182\/blood.V68.5.1175.1175"},{"key":"4","first-page":"e44","volume":"48","author":"EE Smith","year":"2017","unstructured":"4. Smith EE, Saposnik G, Biessels GJ, et al. Prevention of stroke in patients with silent cerebrovascular disease: a scientific statement for healthcare professionals from the American Heart Association\/American Stroke Association. Stroke 48: e44-e71, 2017.","journal-title":"Stroke","ISSN":"https:\/\/id.crossref.org\/issn\/0039-2499","issn-type":"print"},{"key":"5","doi-asserted-by":"publisher","unstructured":"5. Eldor A, Rachmilewitz EA. The hypercoagulable state in thalassemia. Blood 99: 36-43, 2002.","DOI":"10.1182\/blood.V99.1.36"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Taher A, Isma'eel H, Mehio G, et al. Prevalence of thromboembolic events among 8,860 patients with thalassaemia major and intermedia in the Mediterranean area and Iran. Thromb Haemost 96: 488-491, 2006.","DOI":"10.1160\/TH06-05-0267"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Naik RP, Streiff MB, Haywood C, Segal JB, Lanzkron S. Venous thromboembolism incidence in the Cooperative Study of Sickle Cell Disease. J Thromb Haemost 12: 2010-2016, 2014.","DOI":"10.1111\/jth.12744"},{"key":"8","first-page":"288","volume":"91","author":"K Ohene-Frempong","year":"1998","unstructured":"8. Ohene-Frempong K, Weiner SJ, Sleeper LA, et al. Cerebrovascular accidents in sickle cell disease: rates and risk factors. Blood 91: 288-294, 1998.","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"key":"9","doi-asserted-by":"publisher","unstructured":"9. Srisuwananukorn A, Raslan R, Zhang X, et al. Clinical, laboratory, and genetic risk factors for thrombosis in sickle cell disease. Blood Advances 4: 1978-1986, 2020.","DOI":"10.1182\/bloodadvances.2019001384"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Musallam KM, Taher AT, Karimi M, Rachmilewitz EA. Cerebral infarction in \u03b2-thalassemia intermedia: breaking the silence. Thromb Res 130: 695-702, 2012.","DOI":"10.1016\/j.thromres.2012.07.013"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Pegelow CH, Macklin EA, Moser FG, et al. Longitudinal changes in brain magnetic resonance imaging findings in children with sickle cell disease. Blood 99: 3014-3018, 2002.","DOI":"10.1182\/blood.V99.8.3014"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Juul MB, Vestergaard H, Petersen J, Frederiksen H. Thrombosis in Hb Taybe [codons 38\/39 (-ACC) (\u03b11)]. Hemoglobin 36: 600-604, 2012.","DOI":"10.3109\/03630269.2012.746230"},{"key":"13","doi-asserted-by":"publisher","unstructured":"13. Nakamura T, Wada Y, Yoneda M, et al. Acute myocardial infarction caused by abnormal hemoglobinemia associated with thrombocythemia in a young woman. Shinzo 19: 1032-1037, 1987.","DOI":"10.11281\/shinzo1969.19.8_1032"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Kim BJ, Park KW, Koh SB, et al. Stroke induced by splenectomy in hemoglobin Madrid: autopsy clues to the underlying mechanism. Blood Coagul Fibrinolysis 16: 141-144, 2005.","DOI":"10.1097\/01.mbc.0000161568.59140.a3"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Ataga KI, Cappellini MD, Rachmilewitz EA. \u03b2-Thalassaemia and sickle cell anaemia as paradigms of hypercoagulability. Bri J Haematol 139: 3-13, 2007.","DOI":"10.1111\/j.1365-2141.2007.06740.x"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Kenny MW, George AJ, Stuart J. Platelet hyperactivity in sickle-cell disease: a consequence of hyposplenism. J Clin Pathol 33: 622-625, 1980.","DOI":"10.1136\/jcp.33.7.622"},{"key":"17","unstructured":"17. Winichagoon P, Fucharoen S, Wasi P. Increased circulating platelet aggregates in thalassaemia. Southeast Asian J Trop Med Public Health 12: 556-560, 1981."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Butthep P, Rummavas S, Wisedpanichkij R, Jindadamrongwech S, Fucharoen S, Bunyaratvej A. Increased circulating activated endothelial cells, vascular endothelial growth factor, and tumor necrosis factor in thalassemia. Am J Hematol 70: 100-106, 2002.","DOI":"10.1002\/ajh.10101"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Solovey A, Gui L, Key NS, Hebbel RP. Tissue factor expression by endothelial cells in sickle cell anemia. J Clin Invest 101: 1899-1904, 1998.","DOI":"10.1172\/JCI1932"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Piccin A, Murphy C, Eakins E, et al. Insight into the complex pathophysiology of sickle cell anaemia and possible treatment. Eur J Haematol 102: 319-330, 2019.","DOI":"10.1111\/ejh.13212"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Andrieu V, Dumonceau O, Grange MJ. Priapism in a patient with unstable hemoglobin: Hemoglobin K\u00f6ln: case report: priapism in a patient with Hb K\u00f6ln. Am J Hematol 74: 73-74, 2003.","DOI":"10.1002\/ajh.10374"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/63\/13\/63_2775-23\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T03:29:59Z","timestamp":1720236599000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/63\/13\/63_2775-23\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,1]]},"references-count":21,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.2775-23","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,1]]},"article-number":"2775-23"}}