{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T01:20:09Z","timestamp":1782955209614,"version":"3.54.5"},"reference-count":9,"publisher":"Japanese Society of Internal Medicine","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2020,1,15]]},"DOI":"10.2169\/internalmedicine.3098-19","type":"journal-article","created":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T18:04:33Z","timestamp":1568743473000},"page":"293-296","source":"Crossref","is-referenced-by-count":13,"title":["Naldemedine-induced Opioid Withdrawal Syndrome in a Patient with Breast Cancer without Brain Metastasis"],"prefix":"10.2169","volume":"59","author":[{"given":"Koji","family":"Ishii","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Nagasaki University School of Medicine, Japan"},{"name":"Palliative Center, Nagasaki University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruna","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Nagasaki University School of Medicine, Japan"},{"name":"Palliative Center, Nagasaki University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midori","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Nagasaki University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Nagasaki University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emi","family":"Ryu","sequence":"additional","affiliation":[{"name":"Palliative Center, Nagasaki University Hospital, Japan"},{"name":"Department of Hospital Pharmacy, Nagasaki University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Morishita","sequence":"additional","affiliation":[{"name":"Palliative Center, Nagasaki University Hospital, Japan"},{"name":"Department of Nursing, Nagasaki University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumi","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Palliative Center, Nagasaki University Hospital, Japan"},{"name":"Department of Nursing, Nagasaki University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatsugu","family":"Kamada","sequence":"additional","affiliation":[{"name":"Palliative Center, Nagasaki University Hospital, Japan"},{"name":"Department of Clinical Oncology, Nagasaki University Graduate School of Biomedical Science, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsunako","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Palliative Center, Nagasaki University Hospital, Japan"},{"name":"Department of Nursing, Nagasaki University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuto","family":"Ashizawa","sequence":"additional","affiliation":[{"name":"Palliative Center, Nagasaki University Hospital, Japan"},{"name":"Department of Clinical Oncology, Nagasaki University Graduate School of Biomedical Science, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Nagasaki University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Wesson DR, Ling W. The Clinical Opiate Withdrawal Score (COWS). J Psychoactive Drugs 35: 253-259, 2003.","DOI":"10.1080\/02791072.2003.10400007"},{"key":"2","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1053\/j.gastro.2016.02.031","volume":"150","author":"F Mearin","year":"2016","unstructured":"2. Mearin F, Lacy BE, Chang L, et al. Bowel disorders. Gastroenterology 150: 1393-1407, 2016.","journal-title":"Gastroenterology","ISSN":"https:\/\/id.crossref.org\/issn\/0016-5085","issn-type":"print"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Katakami N, Harada T, Murata T, et al. Randomized phase III and extension studies on naldemedine in patients in opioid-induced constipation and cancer. J Clin Oncol 3: 3859-3866, 2017.","DOI":"10.1200\/JCO.2017.73.0853"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed (DSM-5). American Psychiatric Association, Arlington, 2013.","DOI":"10.1176\/appi.books.9780890425596"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Candy B, Jones L, Vickerstaff V, et al. Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer and people receiving palliative care. Cochrane Database Syst Rev 6: CD006332, 2018.","DOI":"10.1002\/14651858.CD006332.pub3"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Webster L, Nagata T, Yamada T, et al. A phase 2a, randomized, double-blind, placebo-controlled, single ascending-dose study to evaluate the safety and efficacy of naldemedine in patients with chronic noncancer pain and opioid-induced bowel dysfunction [abstract no. 479]. J Pain 17 (Suppl): S94, 2016.","DOI":"10.1016\/j.jpain.2016.01.456"},{"key":"7","unstructured":"7. Gavrilovic IT, Posner JB. Brain metastases: epidemiology and pathophysiology. J Neurooncol 75: 5-14, 2005."},{"key":"8","doi-asserted-by":"publisher","unstructured":"8. Zhou W, Fong MY, Min Y, et al. Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis. Cancer Cell 25: 501-515, 2014.","DOI":"10.1016\/j.ccr.2014.03.007"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Tominaga N, Kosaka N, Ono M, et al. Brain metastatic cells release microRNA-181c-containing extracellular vesicles capable of destructing blood-brain barrier. Nat Commun 6: 6716, 2015.","DOI":"10.1038\/ncomms7716"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/59\/2\/59_3098-19\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T22:40:05Z","timestamp":1579300805000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/59\/2\/59_3098-19\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,15]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.3098-19","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,15]]}}}