{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T03:34:52Z","timestamp":1794540892511,"version":"4.9.1"},"reference-count":28,"publisher":"Japanese Society of Internal Medicine","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2024,12,15]]},"DOI":"10.2169\/internalmedicine.3288-23","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T22:12:29Z","timestamp":1714601549000},"page":"3299-3306","source":"Crossref","is-referenced-by-count":7,"title":["A Preliminary Survey of Rheumatologists on the Management of Late-onset Rheumatoid Arthritis in Japan"],"prefix":"10.2169","volume":"63","author":[{"given":"Satoshi","family":"Takanashi","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Kawahito","sequence":"additional","affiliation":[{"name":"Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kida","sequence":"additional","affiliation":[{"name":"Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiko","family":"Sugihara","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihisa","family":"Kojima","sequence":"additional","affiliation":[{"name":"National Hospital Organization Nagoya Medical Center, Orthopaedic Surgery and Rheumatology, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryozo","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kurashiki Sweet Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michinori","family":"Ishitoku","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motomu","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, Osaka Metropolitan University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Hidaka","sequence":"additional","affiliation":[{"name":"Miyazaki-Zenjinkai Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asami","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Niigata Rheumatic Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Niigata Rheumatic Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromu","family":"Ito","sequence":"additional","affiliation":[{"name":"Kurashiki Central Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsumasa","family":"Kishimoto","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Kyorin University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Teine Keijinkai Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Research, Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Kanazawa Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Onishi","sequence":"additional","affiliation":[{"name":"Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Morinobu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichiro","family":"Nishida","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Science of Functional Recovery and Reconstruction, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Asai","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Tokyo Women's Medical University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Harigai","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Tokyo Women's Medical University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayo","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"publisher","unstructured":"1. Smolen JS, Aletaha D, McInnes IB. Rheumatoid arthritis. Lancet 388: 2023-2038, 2016.","DOI":"10.1016\/S0140-6736(16)30173-8"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Kato E, Sawada T, Tahara K, et al. The age at onset of rheumatoid arthritis is increasing in Japan: a nationwide database study. Int J Rheum Dis 20: 839-845, 2017.","DOI":"10.1111\/1756-185X.12998"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Uchiyama S, Takanashi S, Takeno M, et al. Should we reconsider the definition of elderly-onset rheumatoid arthritis in an ageing society? Mod Rheumatol 32: 323-329, 2022.","DOI":"10.1093\/mr\/roab013"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Sugihara T. Treatment strategies for elderly-onset rheumatoid arthritis in the new era. Mod Rheumatol 32: 493-499, 2022.","DOI":"10.1093\/mr\/roab087"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. van Onna M, Boonen A. Challenges in the management of older patients with inflammatory rheumatic diseases. Nat Rev Rheumatol 18: 326-334, 2022.","DOI":"10.1038\/s41584-022-00768-6"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Takanashi S, Takeuchi T, Kaneko Y. Effects of aging on rheumatoid factor and anticyclic citrullinated peptide antibody positivity in patients with rheumatoid arthritis. J Rheumatol 50: 330-334, 2023.","DOI":"10.3899\/jrheum.220526"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Nakajima A, Sakai R, Inoue E, Harigai M. Prevalence of patients with rheumatoid arthritis and age-stratified trends in clinical characteristics and treatment, based on the National Database of Health Insurance Claims and Specific Health Checkups of Japan. Int J Rheum Dis 23: 1676-1684, 2020.","DOI":"10.1111\/1756-185X.13974"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Lu\u00eds M, Freitas J, Costa F, et al. An updated review of glucocorticoid-related adverse events in patients with rheumatoid arthritis. Expert Opin Drug Saf 18: 581-590, 2019.","DOI":"10.1080\/14740338.2019.1615052"},{"key":"9","unstructured":"9. Smolen JS, Landew\u00e9 RBM, Bijlsma JWJ, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update. Ann Rheum Dis 79: 685-699, 2020."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Takanashi S, Kaneko Y, Takeuchi T. CDAI and DAS28 in the management of rheumatoid arthritis in clinical practice. Ann Rheum Dis 79: 671-674, 2020.","DOI":"10.1136\/annrheumdis-2019-216607"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Kojima M, Kawahito Y, Sugihara T, et al. Late-onset rheumatoid arthritis registry study, LORIS study: study protocol and design. BMC Rheumatol 6: 90, 2022.","DOI":"10.1186\/s41927-022-00322-7"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Kanda Y. Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Bone Marrow Transplant 48: 452-458, 2013.","DOI":"10.1038\/bmt.2012.244"},{"key":"13","unstructured":"13. Kato S, Simogaki H, Onodera A, et al. Preparation of revised Hasegawa's Dementia Scale (HDS-R). Ronen Seishin Igaku Zasshi (Jpn J Geriatr Psychiatr) 2: 1339-1347, 1991 [in Japanese]."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Fried LP, Tangen CM, Walston J, et al.; Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56: M146-M156, 2001.","DOI":"10.1093\/gerona\/56.3.M146"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Seichi A, Hoshino Y, Doi T, Akai M, Tobimatsu Y, Iwaya T. Development of a screening tool for risk of locomotive syndrome in the elderly: the 25-question Geriatric Locomotive Function Scale. J Orthop Sci 17: 163-172, 2012.","DOI":"10.1007\/s00776-011-0193-5"},{"key":"16","unstructured":"16. The Japan Geriatrics Society. Kenko Choju Shinryo Handbook. 1st ed. Medical View, Tokyo, 2011: 5-11 (in Japanese)."},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Rom\u00e3o VC, Humby F, Kelly S, et al. Treatment-resistant synovitis and radiographic progression are increased in elderly-onset rheumatoid arthritis patients: findings from a prospective observational longitudinal early arthritis cohort study. Semin Arthritis Rheum 50: 735-743, 2020.","DOI":"10.1016\/j.semarthrit.2020.03.018"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Lee J, Martindale J, Makris UE, Singh N, Yung R, Bynum JPW. Initiation of disease-modifying antirheumatic drugs in older medicare beneficiaries with new diagnosis of late-onset rheumatoid arthritis. ACR Open Rheumatol 5: 694-700, 2023.","DOI":"10.1002\/acr2.11625"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Sugihara T, Ishizaki T, Onoguchi W, et al. Effectiveness and safety of treat-to-target strategy in elderly-onset rheumatoid arthritis: a 3-year prospective observational study. Rheumatology (Oxford) 60: 4252-4261, 2021.","DOI":"10.1093\/rheumatology\/keaa922"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Takanashi S, Kaneko Y, Takeuchi T. Elderly patients with comorbidities in the definition of difficult-to-treat rheumatoid arthritis. Ann Rheum Dis 80: 1491-1493, 2021.","DOI":"10.1136\/annrheumdis-2021-220315"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Takanashi S, Kaneko Y, Takeuchi T. Characteristics of patients with difficult-to-treat rheumatoid arthritis in clinical practice. Rheumatology (Oxford) 60: 5247-5256, 2021.","DOI":"10.1093\/rheumatology\/keab209"},{"key":"22","doi-asserted-by":"publisher","unstructured":"22. Chen DY, Hsieh TY, Chen YM, Hsieh CW, Lan JL, Lin FJ. Proinflammatory cytokine profiles of patients with elderly-onset rheumatoid arthritis: a comparison with younger-onset disease. Gerontology 55: 250-258, 2009.","DOI":"10.1159\/000164393"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Verschueren P, De Cock D, Corluy L, et al. Effectiveness of methotrexate with step-down glucocorticoid remission induction (COBRA Slim) versus other intensive treatment strategies for early rheumatoid arthritis in a treat-to-target approach: 1-year results of CareRA, a randomised pragmatic open-label superiority trial. Ann Rheum Dis 76: 511-520, 2017.","DOI":"10.1136\/annrheumdis-2016-209212"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Boers M, Hartman L, Opris-Belinski D, et al.; GLORIA Trial consortium. Low-dose, add-on prednisolone in patients with rheumatoid arthritis aged 65+: the pragmatic randomized, double-blind placebo-controlled GLORIA trial. Ann Rheum Dis 81: 925-936, 2022.","DOI":"10.1136\/annrheumdis-2021-221957"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Ocon AJ, Reed G, Pappas DA, Curtis JR, Kremer JM. Short-term dose- and duration-dependent glucocorticoid risk for cardiovascular events in glucocorticoid-na\u00efve patients with rheumatoid arthritis. Ann Rheum Dis 80: 1522-1529, 2021.","DOI":"10.1136\/annrheumdis-2021-220577"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Wiebe E, Huscher D, Schaumburg D, et al. Optimising both disease control and glucocorticoid dosing is essential for bone protection in patients with rheumatic disease. Ann Rheum Dis 81: 1313-1322, 2022.","DOI":"10.1136\/annrheumdis-2022-222339"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Barbulescu A, Sj\u00f6lander A, Delcoigne B, Askling J, Frisell T. Glucocorticoid exposure and the risk of serious infections in rheumatoid arthritis: a marginal structural model application. Rheumatology (Oxford) 62: 3391-3399, 2023.","DOI":"10.1093\/rheumatology\/kead083"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Xie W, Huang H, Li G, et al. Dynamical trajectory of glucocorticoids tapering and discontinuation in patients with rheumatoid arthritis commencing glucocorticoids with csDMARDs: real-world data from 2009 to 2020. Ann Rheum Dis 80: 997-1003, 2021.","DOI":"10.1136\/annrheumdis-2021-220112"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/63\/24\/63_3288-23\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T03:30:38Z","timestamp":1734751838000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/63\/24\/63_3288-23\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,15]]},"references-count":28,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.3288-23","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,15]]},"article-number":"3288-23"}}