{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:54:07Z","timestamp":1787068447867,"version":"build-2736575974"},"reference-count":24,"publisher":"Japanese Society of Internal Medicine","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2020,6,15]]},"DOI":"10.2169\/internalmedicine.3521-19","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T18:04:58Z","timestamp":1584554698000},"page":"1473-1480","source":"Crossref","is-referenced-by-count":21,"title":["Usefulness and Limitations of a Serum Screening System to Predict the Risk of Gastric Cancer"],"prefix":"10.2169","volume":"59","author":[{"given":"Takaaki","family":"Kishino","sequence":"first","affiliation":[{"name":"Department of Endoscopy, Saku Central Hospital Advanced Care Center, Japan"},{"name":"Department of Gastroenterology and Hepatology, Center for Digestive and Liver Diseases, Nara City Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuneo","family":"Oyama","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Saku Central Hospital Advanced Care Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihisa","family":"Tomori","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Saku Central Hospital Advanced Care Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Saku Central Hospital Advanced Care Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Shinohara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Saku Central Hospital Advanced Care Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","unstructured":"1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127: 2893-2917, 2010."},{"key":"2","unstructured":"2. Correa P. Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res 52: 6735-6740, 1992."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Uemura N, Okamoto S, Yamamoto S, et al. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med 345: 784-789, 2001.","DOI":"10.1056\/NEJMoa001999"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Miki K, Fujishiro M, Kodashima S, Yahagi N. Long-term results of gastric cancer screening using the serum pepsinogen test method among an asymptomatic middle-aged Japanese population. Dig Endosc 21: 78-81, 2009.","DOI":"10.1111\/j.1443-1661.2009.00839.x"},{"key":"5","unstructured":"5. Yoshihara M, Hiyama T, Yoshida S, et al. Reduction in gastric cancer mortality by screening based on serum pepsinogen concentration: a case-control study. Scand J Gastroenterol 42: 760-764, 2007."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Miki K, Urita Y. Using serum pepsinogens wisely in a clinical practice. J Dig Dis 8: 8-14, 2007.","DOI":"10.1111\/j.1443-9573.2007.00278.x"},{"key":"7","doi-asserted-by":"publisher","unstructured":"7. Miki K. Gastric cancer screening using the serum pepsinogen test method. Gastric Cancer 9: 245-253, 2006.","DOI":"10.1007\/s10120-006-0397-0"},{"key":"8","unstructured":"8. Oishi Y, Kiyohara Y, Kubo M, et al. The serum pepsinogen test as a predictor of gastric cancer: the Hisayama study. Am J Epidemiol 163: 629-637, 2006."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Dinis-Ribeiro M, Yamaki G, Miki K, Costa-Pereira A, Matsukawa M, Kurihara M. Meta-analysis on the validity of pepsinogen test for gastric carcinoma, dysplasia or chronic atrophic gastritis screening. J Med Screen 11: 141-147, 2004.","DOI":"10.1258\/0969141041732184"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Urita Y, Hike K, Torii N, et al. Serum pepsinogens as a predicator of the topography of intestinal metaplasia in patients with atrophic gastritis. Dig Dis Sci 49: 795-801, 2004.","DOI":"10.1023\/B:DDAS.0000030091.92379.91"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Miki K. Gastric cancer screening by combined assay for serum anti-Helicobacter pylori IgG antibody and serum pepsinogen levels -&quot;ABC method&quot;. Proceedings of the Japan Academy Series B, Physical and Biological Sciences 87: 405-414, 2011.","DOI":"10.2183\/pjab.87.405"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Ohata H, Kitauchi S, Yoshimura N, et al. Progression of chronic atrophic gastritis associated with Helicobacter pylori infection increases risk of gastric cancer. Int J Cancer 109: 138-143, 2004.","DOI":"10.1002\/ijc.11680"},{"key":"13","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1136\/gut.2004.055400","volume":"54","author":"H Watabe","year":"2005","unstructured":"13. Watabe H, Mitsushima T, Yamaji Y, et al. Predicting the development of gastric cancer from combining Helicobacter pylori antibodies and serum pepsinogen status: a prospective endoscopic cohort study. Gut 54: 764-768, 2005.","journal-title":"Gut","ISSN":"https:\/\/id.crossref.org\/issn\/0017-5749","issn-type":"print"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Mizuno S, Miki I, Ishida T, et al. Prescreening of a high-risk group for gastric cancer by serologically determined Helicobacter pylori infection and atrophic gastritis. Dig Dis Sci 55: 3132-3137, 2010.","DOI":"10.1007\/s10620-010-1154-0"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Kudo T, Kakizaki S, Sohara N, et al. Analysis of ABC (D) stratification for screening patients with gastric cancer. World J Gastroenterol 17: 4793-4798, 2011.","DOI":"10.3748\/wjg.v17.i43.4793"},{"key":"16","doi-asserted-by":"publisher","unstructured":"16. Boda T, Ito M, Yoshihara M, et al. Advanced method for evaluation of gastric cancer risk by serum markers: determination of true low-risk subjects for gastric neoplasm. Helicobacter 19: 1-8, 2014.","DOI":"10.1111\/hel.12165"},{"key":"17","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1055\/s-0028-1098086","volume":"1","author":"K Kimura","year":"1969","unstructured":"17. Kimura K, Takemoto T. An endoscopic recognition of the atrophic border and its significance in chronic gastritis. Endoscopy 1: 87-97, 1969.","journal-title":"Endoscopy","ISSN":"https:\/\/id.crossref.org\/issn\/0013-726X","issn-type":"print"},{"key":"18","doi-asserted-by":"publisher","unstructured":"18. Kiso M, Yoshihara M, Ito M, et al. Characteristics of gastric cancer in negative test of serum anti-Helicobacter pylori antibody and pepsinogen test: a multicenter study. Gastric Cancer 20: 764-771, 2017.","DOI":"10.1007\/s10120-016-0682-5"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Kishikawa H, Kimura K, Takarabe S, Kaida S, Nishida J. <i>Helicobacter pylori<\/i> antibody titer and gastric cancer screening. Dis Markers 2015: 156719, 2015.","DOI":"10.1155\/2015\/156719"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Kishikawa H, Nishida J, Ichikawa H, et al. Fasting gastric pH of Japanese subjects stratified by IgG concentration against <i>Helicobacter pylori<\/i> and pepsinogen status. Helicobacter 16: 427-433, 2011.","DOI":"10.1111\/j.1523-5378.2011.00868.x"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Ueda J, Okuda M, Nishiyama T, Lin Y, Fukuda Y, Kikuchi S. Diagnostic accuracy of the E-plate serum antibody test kit in detecting <i>Helicobacter pylori<\/i> infection among Japanese children. J Epidemiol 24: 47-51, 2014.","DOI":"10.2188\/jea.JE20130078"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Itoh T, Saito M, Marugami N, et al. Correlation between the ABC classification and radiological findings for assessing gastric cancer risk. Jpn J Radiol 33: 636-644, 2015.","DOI":"10.1007\/s11604-015-0469-3"},{"key":"23","unstructured":"23. Ueyama H, Yao T, Nakashima Y, et al. Gastric adenocarcinoma of fundic gland type (chief cell predominant type): proposal for a new entity of gastric adenocarcinoma. Am J Surg Pathol 34: 609-619, 2010."},{"key":"24","doi-asserted-by":"publisher","unstructured":"24. Matsuo T, Ito M, Takata S, Tanaka S, Yoshihara M, Chayama K. Low prevalence of <i>Helicobacter pylori<\/i>-negative gastric cancer among Japanese. Helicobacter 16: 415-419, 2011.","DOI":"10.1111\/j.1523-5378.2011.00889.x"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/59\/12\/59_3521-19\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T23:30:06Z","timestamp":1592609406000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/59\/12\/59_3521-19\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,15]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.3521-19","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,15]]}}}