{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T04:40:10Z","timestamp":1737175210247,"version":"3.33.0"},"reference-count":24,"publisher":"Japanese Society of Internal Medicine","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2025,1,15]]},"DOI":"10.2169\/internalmedicine.3672-24","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T22:12:50Z","timestamp":1717020770000},"page":"237-242","source":"Crossref","is-referenced-by-count":0,"title":["Ectopic Adrenocorticotropic Hormone Syndrome due to Pancreatic Neuroendocrine Carcinoma"],"prefix":"10.2169","volume":"64","author":[{"given":"Aya","family":"Kawanishi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Tokai University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuzo","family":"Deguchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tokai University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayano","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tokai University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tokai University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kota","family":"Tsuruya","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tokai University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Arase","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tokai University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Shirataki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tokai University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Kodama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tokai University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Morimachi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tokai University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatehiro","family":"Kagawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tokai University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"962","reference":[{"unstructured":"1. McKenna LR, Edil BH. Update on pancreatic neuroendocrine tumors. Gland Surg 3: 258-275, 2014.","key":"1"},{"doi-asserted-by":"crossref","unstructured":"2. Ito T, Tanaka M, Sasano H, et al.; The Neuroendocrine Tumor Workshop of Japan. Preliminary results of a Japanese nationwide survey of neuroendocrine gastrointestinal tumors. J Gastroenterol 42: 497-500, 2007.","key":"2","DOI":"10.1007\/s00535-007-2056-6"},{"doi-asserted-by":"crossref","unstructured":"3. Bakker RC, Gallas PR, Romijn JA, Wiersinga WM. Cushing&apos;s syndrome complicated by multiple opportunistic infections. J Endocrinol Invest 21: 329-333, 1998.","key":"3","DOI":"10.1007\/BF03350337"},{"doi-asserted-by":"crossref","unstructured":"4. Ito T, Igarashi H, Nakamura K, et al. Epidemiological trends of pancreatic and gastrointestinal neuroendocrine tumors in Japan: a nationwide survey analysis. J Gastroenterol 50: 58-64, 2015.","key":"4","DOI":"10.1007\/s00535-014-0934-2"},{"doi-asserted-by":"crossref","unstructured":"5. Maragliano R, Vanoli A, Albarello L, et al. ACTH-secreting pancreatic neoplasms associated with Cushing syndrome: clinicopathologic study of 11 cases and review of the literature. Am J Surg Pathol 39: 374-382, 2015.","key":"5","DOI":"10.1097\/PAS.0000000000000340"},{"doi-asserted-by":"crossref","unstructured":"6. Zhang C, Jin J, Xie J, et al. The clinical features and molecular mechanisms of ACTH-secreting pancreatic neuroendocrine tumors. J Clin Endocrinol Metab 105: dgaa507, 2020.","key":"6","DOI":"10.1210\/clinem\/dgaa507"},{"doi-asserted-by":"crossref","unstructured":"7. Qu Y, Li H, Wang X, et al. Clinical characteristics and management of functional pancreatic neuroendocrine neoplasms: a single institution 20-year experience with 286 patients. Int J Endocrinol 2020: 1030518, 2020.","key":"7","DOI":"10.1155\/2020\/1030518"},{"doi-asserted-by":"crossref","unstructured":"8. Beuschlein F, Hammer GD. Ectopic pro-opiomelanocortin syndrome. Endocrinol Metab Clin North Am 31: 191-234, 2002.","key":"8","DOI":"10.1016\/S0889-8529(01)00025-1"},{"doi-asserted-by":"crossref","unstructured":"9. Mathioudakis N, Pendleton C, Quinones-Hinojosa A, Wand GS, Salvatori R. ACTH-secreting pituitary adenomas: size does not correlate with hormonal activity. Pituitary 15: 526-553, 2012.","key":"9","DOI":"10.1007\/s11102-011-0362-8"},{"doi-asserted-by":"crossref","unstructured":"10. Dogansen SC, Yalin GY, Canbaz B, Tanrikulu S, Yarman S. Dynamic changes of central thyroid functions in the management of Cushing&apos;s syndrome. Arch Endocrinol Metab 62: 164-171, 2018.","key":"10","DOI":"10.20945\/2359-3997000000019"},{"unstructured":"11. Ishibashi M. [Ectopic hormone-producing tumor]. Nihon Rinsho (Jpn J Clin Med) 62: 894-900, 2004.","key":"11"},{"doi-asserted-by":"crossref","unstructured":"12. Isidori AM, Kaltsas GA, Grossman AB. Ectopic ACTH syndrome. Front Horm Res 35: 143-156, 2006.","key":"12","DOI":"10.1159\/000094323"},{"doi-asserted-by":"crossref","unstructured":"13. Schreiter NF, Bartels AM, Froeling V, et al. Searching for primaries in patients with neuroendocrine tumors (NET) of unknown primary and clinically suspected NET: evaluation of Ga-68 DOTATOC PET\/CT and In-111 DTPA octreotide SPECT\/CT. Radiol Oncol 48: 339-347, 2014.","key":"13","DOI":"10.2478\/raon-2014-0018"},{"doi-asserted-by":"crossref","unstructured":"14. Venugopal H, Griffin K, Amer S. A case of severe ectopic ACTH syndrome from an occult primary - diagnostic and management dilemmas. Endocrinol Diabetes Metab Case Rep 2015: 150099, 2015.","key":"14","DOI":"10.1530\/EDM-15-0099"},{"doi-asserted-by":"crossref","unstructured":"15. Grossman AB, Kelly P, Rockall A, Bhattacharya S, McNicol A, Barwick T. Cushing&apos;s syndrome caused by an occult source: difficulties in diagnosis and management. Nat Clin Pract Endocrinol Metab 2: 642-647, 2006.","key":"15","DOI":"10.1038\/ncpendmet0327"},{"doi-asserted-by":"publisher","unstructured":"16. de Ridder J, de Wilt JH, Simmer F, Overbeek L, Lemmens V, Nagtegaal I. Incidence and origin of histologically confirmed liver metastases: an explorative case-study of 23,154 patients. Oncotarget 7: 55368-55376, 2016.","key":"16","DOI":"10.18632\/oncotarget.10552"},{"doi-asserted-by":"crossref","unstructured":"17. Jin K, Xu J, Chen J, et al. Surgical management for non-functional pancreatic neuroendocrine neoplasms with synchronous liver metastasis: a consensus from the Chinese Study Group for Neuroendocrine Tumors (CSNET). Int J Oncol 49: 1991-2000, 2016.","key":"17","DOI":"10.3892\/ijo.2016.3711"},{"doi-asserted-by":"crossref","unstructured":"18. Singh S, Dey C, Kennecke H, et al. Consensus recommendations for the diagnosis and management of pancreatic neuroendocrine tumors: guidelines from a Canadian National Expert Group. Ann Surg Oncol 22: 2685-2699, 2015.","key":"18","DOI":"10.1245\/s10434-014-4145-0"},{"doi-asserted-by":"crossref","unstructured":"19. Ambler L, Bennett HP, Hudson AM, McMartin C. Fate of human corticotrophin immediately after intravenous administration to the rat. J Endocrinol 93: 287-292, 1982.","key":"19","DOI":"10.1677\/joe.0.0930287"},{"doi-asserted-by":"crossref","unstructured":"20. Kondo T, Matsuyama R, Ashihara H, et al. A case of ectopic adrenocorticotropic hormone-producing pancreatic neuroendocrine tumor with multiple liver metastases. Endocr J 57: 229-236, 2010.","key":"20","DOI":"10.1507\/endocrj.K09E-179"},{"unstructured":"21. Morizane C, Machida N, Honma Y, et al.; the Japan Clinical Oncology Group (JCOG). Effectiveness of etoposide and cisplatin vs irinotecan and cisplatin therapy for patients with advanced neuroendocrine carcinoma of the digestive system: the TOPIC-NEC phase 3 randomized clinical trial. JAMA Oncol 8: 1447-1455, 2022.","key":"21"},{"doi-asserted-by":"crossref","unstructured":"22. Luo W, Zhang T. Primary tumor resection enhances the survival of pancreatic neuroendocrine carcinoma patients with liver metastasis under the definition of 2019 WHO classification. J Cancer Res Clin Oncol 149: 9201-9212, 2023.","key":"22","DOI":"10.1007\/s00432-023-04847-3"},{"doi-asserted-by":"crossref","unstructured":"23. Frizziero M, Spada F, Lamarca A, et al. Carboplatin in combination with oral or intravenous etoposide for extra-pulmonary, poorly-differentiated neuroendocrine carcinomas. Neuroendocrinology 109: 100-112, 2019.","key":"23","DOI":"10.1159\/000497336"},{"unstructured":"24. Shah MH, Goldner WS, Benson AIB, et al. Neuroendocrine and adrenal tumors, version 2.2021, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw 19: 839-868, 2021.","key":"24"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/64\/2\/64_3672-24\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T03:30:03Z","timestamp":1737171003000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/64\/2\/64_3672-24\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,15]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.3672-24","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"type":"print","value":"0918-2918"},{"type":"electronic","value":"1349-7235"}],"subject":[],"published":{"date-parts":[[2025,1,15]]},"article-number":"3672-24"}}