{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T18:00:34Z","timestamp":1780077634121,"version":"3.54.0"},"reference-count":41,"publisher":"Japanese Society of Internal Medicine","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2020,2,15]]},"DOI":"10.2169\/internalmedicine.3745-19","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T22:03:17Z","timestamp":1571090597000},"page":"501-505","source":"Crossref","is-referenced-by-count":14,"title":["Clinical and Endoscopic Characteristics of Pyogenic Granuloma in the Small Intestine: A Case Series with Literature Review"],"prefix":"10.2169","volume":"59","author":[{"given":"Yukie","family":"Hayashi","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Hosoe","sequence":"additional","affiliation":[{"name":"Center for Diagnostic and Therapeutic Endoscopy, Keio University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Takabayashi","sequence":"additional","affiliation":[{"name":"Center for Diagnostic and Therapeutic Endoscopy, Keio University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji JL Limpias","family":"Kamiya","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Mutaguchi","sequence":"additional","affiliation":[{"name":"Center for Diagnostic and Therapeutic Endoscopy, Keio University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoichi","family":"Miyanaga","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenro","family":"Hirata","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiichiro","family":"Fukuhara","sequence":"additional","affiliation":[{"name":"Center for Diagnostic and Therapeutic Endoscopy, Keio University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Mikami","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohisa","family":"Sujino","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Masugi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Keio University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Naganuma","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Ogata","sequence":"additional","affiliation":[{"name":"Center for Diagnostic and Therapeutic Endoscopy, Keio University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Kanai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","unstructured":"1. Poncet A, Dor L. Botruomycose humaine. Rev Chir 18: 996, 1897."},{"key":"2","unstructured":"2. Hartzell MB. Granuloma pyogenicum. J Cutan Dis 22: 520-523, 1904."},{"key":"3","unstructured":"3. Moffatt DC, Warwryko P, Singh H. Pyogenic granuloma: an unusual cause of massive gastrointestinal bleeding from the small bowel. Can J Gastroenterol 23: 261-264, 2009."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Lewis BS. Small intestinal bleeding. Gastroenterol Clin North Am 29: 67-95, vi, 2000.","DOI":"10.1016\/S0889-8553(05)70108-4"},{"key":"5","unstructured":"5. Motohashi Y, Hisamatsu T, Ikezawa T, et al. [A case of pyogenic granuloma in the small intestine]. Nihon Shokakibyo Gakkai Zasshi 96: 1396-1400, 1999 (in Japanese)."},{"key":"6","unstructured":"6. Payson BA, Karpas CM, Exelby P. Intussusception due to pyogenic granuloma of ileum. N Y State J Med 67: 2135-2138, 1967."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Meuwissen SG, Willig AP, Hausman R, Starink TM, Mathus-Vliegen EM. Multiple angiomatous proliferations of ileal stoma following <i>Campylobacter enteritis<\/i>. Effect of laser photocoagulation. Dig Dis Sci 31: 327-332, 1986.","DOI":"10.1007\/BF01318126"},{"key":"8","unstructured":"8. Iwakubo A, Tsuda T, Kubota M, Wakabayashi J, Kobayashi K, Morita K. [Diagnostic <sup>99m<\/sup>Tc-labeled red blood cells scintigraphy in gastrointestinal tract bleeding from an intestinal pyogenic granuloma]. Kaku Igaku 26: 1439-1443, 1989 (in Japanese, Abstract in English)."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Hizawa K, Iida M, Matsumoto T, Kohrogi N, Yao T, Fujishima M. Neoplastic transformation arising in Peutz-Jeghers polyposis. Dis Colon Rectum 36: 953-957, 1993.","DOI":"10.1007\/BF02050632"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Yao T, Nagai E, Utsunomiya T, Tsuneyoshi M. An intestinal counterpart of pyogenic granuloma of the skin. A newly proposed entity. Am J Surg Pathol 19: 1054-1060, 1995.","DOI":"10.1097\/00000478-199509000-00009"},{"key":"11","unstructured":"11. Hirakawa K, Aoyagi K, Yao T, Hizawa K, Kido H, Fujishima M. A case of pyogenic granuloma in the duodenum: successful treatment by endoscopic snare polypectomy. Gastrointest Endosc 47: 538-540, 1998."},{"key":"12","unstructured":"12. van Eeden S, Offerhaus GJ, Morsink FH, van Rees BP, Busch OR, van Noesel CJ. Pyogenic granuloma: an unrecognized cause of gastrointestinal bleeding. Virchows Arch 444: 590-593, 2004."},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Shirakawa K, Nakamura T, Endo M, Suzuki K, Fujimori T, Terano A. Pyogenic granuloma of the small intestine. Gastrointest Endosc 66: 827-828, 2007discussion 828.","DOI":"10.1016\/j.gie.2007.04.018"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Chou JW, Lai HC, Lin YC. Image of the month. Pyogenic granuloma of the small bowel diagnosed by capsule endoscopy and double-balloon enteroscopy. Clin Gastroenterol Hepatol 7: A26, 2009.","DOI":"10.1016\/j.cgh.2008.10.030"},{"key":"15","unstructured":"15. Stojsic Z, Brasanac D, Kokai G, et al. Intestinal intussusception due to a pyogenic granuloma. Turk J Pediatr 50: 600-603, 2008."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Kuga R, Furuya CK Jr., Fylyk SN, Sakai P. Solitary pyogenic granuloma of the small bowel as the cause of obscure gastrointestinal bleeding. Endoscopy 41 (Suppl 2): E76-E77, 2009.","DOI":"10.1055\/s-0029-1214428"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Nagoya H, Tanaka S, Tatsuguchi A, et al. Rare cause of obscure gastrointestinal bleeding due to pyogenic granuloma in the ileum detected by capsule endoscopy and treated with double balloon endoscopy. Dig Endosc 22: 71-73, 2010.","DOI":"10.1111\/j.1443-1661.2009.00928.x"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Yamashita K, Arimura Y, Saito M, et al. Pyogenic granuloma of the small bowel. Endoscopy 45 (Suppl 2 UCTN): E9-E10, 2013.","DOI":"10.1055\/s-0032-1326119"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Kikuchi A, Sujino T, Yamaoka M, et al. Pyogenic granuloma of the ileum diagnosed by double-balloon enteroscopy. Intern Med 53: 2057-2059, 2014.","DOI":"10.2169\/internalmedicine.53.2468"},{"key":"20","unstructured":"20. Hirata K, Hosoe N, Imaeda H, et al. Obscure gastrointestinal bleeding: resection of a pyogenic granuloma of the ileum via double-balloon enteroscopy. Clin J Gastroenterol 7: 397-401, 2014."},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Misawa S, Sakamoto H, Kurogochi A, et al. Rare cause of severe anemia due to pyogenic granuloma in the jejunum. BMC Gastroenterol 15: 126, 2015.","DOI":"10.1186\/s12876-015-0355-6"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Iravani A, Law A, Millward M, Warner M, Sparrow S. Bleeding small intestine pyogenic granuloma on <sup>18<\/sup>F-FDG PET\/CT. Clin Nucl Med 40: 869-870, 2015.","DOI":"10.1097\/RLU.0000000000000929"},{"key":"23","unstructured":"23. Katsurahara M, Kitade T, Tano S, et al. Pyogenic granuloma in the small intestine: a rare cause of obscure gastrointestinal bleeding. Endoscopy 47 (Suppl 1 UCTN): E133-E134, 2015."},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Kawasaki K, Kurahara K, Matsumoto T. Pyogenic granuloma of the ileum depicted by small-bowel radiography, capsule endoscopy and double balloon endoscopy. Dig Liver Dis 47: 436, 2015.","DOI":"10.1016\/j.dld.2014.11.014"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Mizutani Y, Hirooka Y, Watanabe O, et al. Pyogenic granuloma of the small bowel treated by double-balloon enteroscopy. Gastrointest Endosc 81: 1023-1024, 2015.","DOI":"10.1016\/j.gie.2014.11.005"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Korc P, McHenry L. An uncommon cause of chronic upper GI bleeding. Gastrointest Endosc 84: 524, 2016.","DOI":"10.1016\/j.gie.2016.03.1483"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Romero Mascarell C, Garc\u00eda Pag\u00e1n JC, Araujo IK, Llach J, Gonz\u00e1lez-Su\u00e1rez B. Pyogenic granuloma in the jejunum successfully removed by single-balloon enteroscopy. Rev Esp Enferm Dig 109: 152-154, 2016.","DOI":"10.17235\/reed.2017.4153\/2015"},{"key":"28","unstructured":"28. Castela J, Mao de Ferro S, Ferreira S, Cabrera R, Dias Pereira A. Pyogenic granuloma of the jejunum: an unusual cause of anemia. J Gastrointest Surg 22: 1795-1796, 2018."},{"key":"29","unstructured":"29. Moreira Silva H, Silva G, Costa E, Lima R, Pereira F. Pyogenic granuloma of the ampulla of Vater: unexpected cause of gastrointestinal bleeding. Clin J Gastroenterol 12: 34-37, 2019."},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Zhang D, Glover SC, Liu W, Liu X, Lai J. Small bowel pyogenic granuloma with cytomegalovirus infection in a patient with Crohn&apos;s disease (report of a case and review of the literature). In Vivo 33: 251-254, 2019.","DOI":"10.21873\/invivo.11468"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Kim YS, Chun HJ, Jeen YT, Um SH, Kim CD, Hyun JH. Small bowel capillary hemangioma. Gastrointest Endosc 60: 599, 2004.","DOI":"10.1016\/S0016-5107(04)01859-0"},{"key":"32","unstructured":"32. Sasaki M, Nakamura F, Koyama S, Fujiyama Y, Bamba T, Okabe H. Case report: haemangioma of the small intestine complicated by protein-losing gastroenteropathy. J Gastroenterol Hepatol 13: 387-390, 1998."},{"key":"33","unstructured":"33. Kavin H, Berman J, Martin TL, Feldman A, Forsey-Koukol K. Successful wireless capsule endoscopy for a 2.5-year-old child: obscure gastrointestinal bleeding from mixed, juvenile, capillary hemangioma-angiomatosis of the jejunum. Pediatrics 117: 539-543, 2006."},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Wardi J, Shahmurov M, Czerniak A, Avni Y. Clinical challenges and images in GI. Capillary hemangioma of small intestine. Gastroenterology 132: 1656, 2084, 2007.","DOI":"10.1053\/j.gastro.2007.03.081"},{"key":"35","unstructured":"35. Wang B, Lou Z, Zheng W, Zhang J, Liu J. Capillary hemangioma in the ileum: obscure small-bowel bleeding in an elderly person. Turk J Gastroenterol 29: 520-521, 2018."},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Santos J, Ruiz-Tovar J, Lopez A, Arroyo A, Calpena R. Simultaneous massive low gastrointestinal bleeding and hemoperitoneum caused by a capillary hemangioma in ileocecal valve. Int J Colorectal Dis 26: 1363-1364, 2011.","DOI":"10.1007\/s00384-011-1142-7"},{"key":"37","unstructured":"37. Lee MH, Yen HH, Chen YY, Chen CJ, Soon MS. Combined capillary hemangioma and angiodysplasia of the ileum: an unusual cause of obscure gastrointestinal bleeding with preoperative localization by double-balloon endoscopy. Am J Surg 200: e30-e32, 2010."},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Yamamoto H, Ogata H, Matsumoto T, et al. Clinical practice guideline for enteroscopy. Dig Endosc 29: 519-546, 2017.","DOI":"10.1111\/den.12883"},{"key":"39","doi-asserted-by":"publisher","unstructured":"39. Pennazio M, Santucci R, Rondonotti E, et al. Outcome of patients with obscure gastrointestinal bleeding after capsule endoscopy: report of 100 consecutive cases. Gastroenterology 126: 643-653, 2004.","DOI":"10.1053\/j.gastro.2003.11.057"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Carey EJ, Leighton JA, Heigh RI, et al. A single-center experience of 260 consecutive patients undergoing capsule endoscopy for obscure gastrointestinal bleeding. Am J Gastroenterol 102: 89-95, 2007.","DOI":"10.1111\/j.1572-0241.2006.00941.x"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Handa O, Naito Y, Okayama T, et al. Endoscopic diagnosis of small intestinal diseases. Clin J Gastroenterol 6: 94-98, 2013.","DOI":"10.1007\/s12328-013-0364-3"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/59\/4\/59_3745-19\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,15]],"date-time":"2020-02-15T03:39:54Z","timestamp":1581737994000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/59\/4\/59_3745-19\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,15]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.3745-19","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,15]]}}}