{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T09:48:09Z","timestamp":1773827289900,"version":"3.50.1"},"reference-count":13,"publisher":"Japanese Society of Internal Medicine","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2025,2,1]]},"DOI":"10.2169\/internalmedicine.3896-24","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T22:14:11Z","timestamp":1719440051000},"page":"387-391","source":"Crossref","is-referenced-by-count":1,"title":["Secondary Growth Hormone Deficiency That Developed into Cirrhosis after Several Years of Interrupted Growth Hormone Replacement Therapy"],"prefix":"10.2169","volume":"64","author":[{"given":"Ayana","family":"Sueki","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Nara Prefecture General Medical Center, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nara Prefecture General Medical Center, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsaku","family":"Nagamatsu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nara Prefecture General Medical Center, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chisa","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nara Prefecture General Medical Center, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Ohta","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nara Prefecture General Medical Center, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuya","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nara Prefecture General Medical Center, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuya","family":"Nishio","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nara Prefecture General Medical Center, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Komeda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nara Prefecture General Medical Center, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoma","family":"Kikukawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nara Prefecture General Medical Center, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyohei","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nara Prefecture General Medical Center, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nara Prefecture General Medical Center, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakazu","family":"Uejima","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Nara Prefecture General Medical Center, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Moriya","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nara Prefecture General Medical Center, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Dolce A, Della Torre S. Sex, nutrition, and NAFLD: relevance of environmental pollution. Nutrients 15: 2335, 2023.","DOI":"10.3390\/nu15102335"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Njei B, Al-Ajlouni YA, Ugwendum D, Abdu M, Forjindam A, Mohamed MF. Genetic and epigenetic determinants of non-alcoholic fatty liver disease (NAFLD) in lean individuals: a systematic review. Transl Gastroenterol Hepatol 9: 11, 2023.","DOI":"10.21037\/tgh-23-31"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Cernea S. NAFLD fibrosis progression and type 2 diabetes: the hepatic-metabolic interplay. Life (Basel) 14: 272, 2024.","DOI":"10.3390\/life14020272"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Konyn P, Ahmed A, Kim D. Causes and risk profiles of mortality among individuals with nonalcoholic fatty liver disease. Clin Mol Hepatol 29: S43-S57, 2023.","DOI":"10.3350\/cmh.2022.0351"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Gariani K, Jornayvaz FR. Pathophysiology of NASH in endocrine diseases. Endocr Connect 10: R52-R65, 2021.","DOI":"10.1530\/EC-20-0490"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Crane H, Gofton C, Sharma A, George J. MAFLD: an optimal framework for understanding liver cancer phenotypes. J Gastroenterol 58: 947-964, 2023.","DOI":"10.1007\/s00535-023-02021-7"},{"key":"7","doi-asserted-by":"publisher","unstructured":"7. Tilg H, Moschen AR. Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology 52: 1836-1846, 2010.","DOI":"10.1002\/hep.24001"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Takahashi Y. Nonalcoholic fatty liver disease and adult growth hormone deficiency: an under-recognized association? Best Pract Res Clin Endocrinol Metab 37: 101816, 2013.","DOI":"10.1016\/j.beem.2023.101816"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Suzuki K, Kanamoto M, Hinohara H, Saito S. A case of hypopituitarism complicated by non-alcoholic steatohepatitis and severe pulmonary hypertension. Am J Case Rep 22: e928004, 2021.","DOI":"10.12659\/AJCR.928004"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Takahashi Y. The role of growth hormone and insulin-like growth factor-I in the liver. Int J Mol Sci 18: 1447, 2017.","DOI":"10.3390\/ijms18071447"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Kong T, Gu Y, Sun L, Zhou R, Li J, Shi J. Association of nonalcoholic fatty liver disease and growth hormone deficiency: a systematic review and meta-analysis. Endocr J 70: 959-967, 2023.","DOI":"10.1507\/endocrj.EJ23-0157"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Nishizawa H, Iguchi G, Murawaki A, et al. Nonalcoholic fatty liver disease in adult hypopituitary patients with GH deficiency and the impact of GH replacement therapy. Eur J Endocrinol 167: 67-74, 2012.","DOI":"10.1530\/EJE-12-0252"},{"key":"13","doi-asserted-by":"publisher","unstructured":"13. Adams LA, Feldstein A, Lindor KD, Angulo P. Nonalcoholic fatty liver disease among patients with hypothalamic and pituitary dysfunction. Hepatology 39: 909-914, 2004.","DOI":"10.1002\/hep.20140"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/64\/3\/64_3896-24\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T03:36:46Z","timestamp":1738381006000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/64\/3\/64_3896-24\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,1]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.3896-24","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,1]]},"article-number":"3896-24"}}