{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T21:41:12Z","timestamp":1768340472675,"version":"3.49.0"},"reference-count":39,"publisher":"Japanese Society of Internal Medicine","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2020,4,15]]},"DOI":"10.2169\/internalmedicine.3954-19","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T22:04:47Z","timestamp":1580508287000},"page":"1099-1104","source":"Crossref","is-referenced-by-count":4,"title":["Beh\u00e7et's Disease with Severe Autonomic Disorders Developing after Herpes Zoster"],"prefix":"10.2169","volume":"59","author":[{"given":"Serina","family":"Koto","sequence":"first","affiliation":[{"name":"Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan"},{"name":"Department of Rheumatology, Sasebo City General Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masataka","family":"Umeda","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan"},{"name":"Medical Education Development Center, Nagasaki University Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Kawano","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yushiro","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshimasa","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Koga","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiro","family":"Ichinose","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Mukaino","sequence":"additional","affiliation":[{"name":"Department of Molecular Neurology and Therapeutics, Kumamoto University Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Nagasaki Kawatana Medical Center, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunya","family":"Nakane","sequence":"additional","affiliation":[{"name":"Department of Molecular Neurology and Therapeutics, Kumamoto University Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Karatas GK, Onder M, Meray J. Autonomic nervous system involvement in Beh\u00e7et&apos;s disease. Rheumatol Int 22: 155-159, 2002.","DOI":"10.1007\/s00296-002-0220-0"},{"key":"2","unstructured":"2. Hedayatfar A. Beh\u00e7et&apos;s disease: autoimmune or autoinflammatory? J Ophthalmic Vis Res 8: 291-293, 2013."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Galeone M, Colucci R, D&apos;Erme AM, Moretti S, Lotti T. Potential infectious etiology of Beh\u00e7et&apos;s disease. Patholog Res Int 2012: 595380, 2012.","DOI":"10.1155\/2012\/595380"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Stewart JM. Common syndromes of orthostatic intolerance. Pediatrics 131: 968-980, 2013.","DOI":"10.1542\/peds.2012-2610"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Garner R, Baraniuk JN. Orthostatic intolerance in chronic fatigue syndrome. J Transl Med 17: 185, 2019.","DOI":"10.1186\/s12967-019-1935-y"},{"key":"6","unstructured":"6. Hirohata S, Kikuchi H, Sawada T, et al. Clinical characteristics of neuro-Beh\u00e7et&apos;s disease in Japan: a multicenter retrospective analysis. Mod rheumatol 22: 405-413, 2012."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Akdeniz S, Harman M, Atmaca S, Akpolat N. The seroprevalence of varicella zoster antibodies in Beh\u00e7et&apos;s and other skin diseases. Eur J Epidemiol 18: 91-93, 2003.","DOI":"10.1023\/A:1022537209948"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Marta M, Santos E, Coutinho E, et al. The role of infections in Beh\u00e7et disease and neuro-Beh\u00e7et syndrome. Autoimmun Rev 14: 609-615, 2015.","DOI":"10.1016\/j.autrev.2015.02.009"},{"key":"9","unstructured":"9. Wang TJ, Hu CC, Lin HC. Increased risk of anterior uveitis following herpes zoster: a nationwide population-based study. Arch Ophthalmol 130: 451-455, 2012."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Sugata K, Enomoto Y, Sugiyama H, et al. Single episode of Beh\u00e7et&apos;s disease-like symptoms caused by herpes simplex virus reactivation. Pediatr Int 51: 577-578, 2009.","DOI":"10.1111\/j.1442-200X.2009.02869.x"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Islam SMS, Sohn S. HSV-induced systemic inflammation as an animal model for Beh\u00e7et&apos;s disease and therapeutic applications. Viruses 10: 2018.","DOI":"10.3390\/v10090511"},{"key":"12","unstructured":"12. Takeuchi M, Kastner DL, Remmers EF. The immunogenetics of Beh\u00e7et&apos;s disease: a comprehensive review. J Autoimmun 64: 137-148, 2015."},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Fiorentino DF, Zlotnik A, Vieira P, et al. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J Immunol 146: 3444-3451, 1991.","DOI":"10.4049\/jimmunol.146.10.3444"},{"key":"14","unstructured":"14. Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7: 145-173, 1989."},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Talaat RM, Ashour ME, Bassyouni IH, Raouf AA. Polymorphisms of interleukin 6 and interleukin 10 in Egyptian people with Beh\u00e7et&apos;s disease. Immunobiology 219: 573-852, 2014.","DOI":"10.1016\/j.imbio.2014.03.004"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Remmers EF, Cosan F, Kirino Y, et al. Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Beh\u00e7et&apos;s disease. Nat Genet 42: 698-702, 2010.","DOI":"10.1038\/ng.625"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Jenkins DE, Redman RL, Lam EM, Liu C, Lin I, Arvin AM. Interleukin (IL)-10, IL-12, and interferon-gamma production in primary and memory immune responses to varicella-zoster virus. J Infect Dis 178: 940-948, 1998.","DOI":"10.1086\/515702"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Haanpaa M, Nurmikko T, Hurme M. Polymorphism of the IL-10 gene is associated with susceptibility to herpes zoster. Scand J Infect Dis 34: 112-114, 2002.","DOI":"10.1080\/00365540110077218"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Zajkowska A, Garkowski A, Swierzbinska R, et al. Evaluation of chosen cytokine levels among patients with herpes zoster as ability to provide immune response. PLoS One 11: e0150301, 2016.","DOI":"10.1371\/journal.pone.0150301"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Zhu SM, Liu YM, An ED, Chen QL. Influence of systemic immune and cytokine responses during the acute phase of zoster on the development of postherpetic neuralgia. J Zhejiang Univ Sci B 10: 625-630, 2009.","DOI":"10.1631\/jzus.B0920049"},{"key":"21","unstructured":"21. Bayramlar H, Hepsen IF, Uguralp M, Boluk A, Ozcan C. Autonomic nervous system involvement in Beh\u00e7et&apos;s disease: a pupillometric study. J Neuroophthalmol 18: 182-186, 1998."},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Aksoyek S, Aytemir K, Ozer N, Ozcebe O, Oto A. Assessment of autonomic nervous system function in patients with Beh\u00e7et&apos;s disease by spectral analysis of heart rate variability. J Auton Nerv Syst 77: 190-194, 1999.","DOI":"10.1016\/S0165-1838(99)00045-4"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Akyol M, Turaclar U, Kececi H, et al. Electrodermal activities and autonomic nervous system in Beh\u00e7et&apos;s patients. Neurol Sci 23: 55-58, 2002.","DOI":"10.1007\/s100720200026"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Ozdemir R, Sezgin AT, Topal E, Kutlu R, Barutcu I, Gullu H. Findings of ambulatory blood pressure monitoring and heart rate variability in patients with Beh\u00e7et&apos;s disease. Am J Cardiol 92: 646-648, 2003.","DOI":"10.1016\/S0002-9149(03)00747-1"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Gulturk S, Akyol M, Kececi H, Ozcelik S, Cinar Z, Demirkazik A. Delayed habituation in Beh\u00e7et&apos;s disease. Neurol India 56: 27-30, 2008.","DOI":"10.4103\/0028-3886.39308"},{"key":"26","unstructured":"26. Kirimli O, Aslan O, Goldeli O, et al. Heart rate variability, late potentials and QT dispersion as markers of myocardial involvement in patients with Beh\u00e7et&apos;s disease. Can J Cardiol 16: 345-351, 2000."},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Tellioglu T, Robertson D. Orthostatic intolerance in Beh\u00e7et&apos;s disease. Auton Neurosci 89: 96-99, 2001.","DOI":"10.1016\/S1566-0702(01)00243-0"},{"key":"28","unstructured":"28. Borman P, Tuncay F, Kocaoglu S, Okumus M, Gungor E, Eksioglu M. The subclinic autonomic dysfunction in patients with Beh\u00e7et disease: an electrophysiological study. Clin Rheumatol 31: 41-47, 2012."},{"key":"29","unstructured":"29. Polat V, Gur AK, Dogdu O. Prolonged asystole during head-up tilt testing in a patient with Beh\u00e7et&apos;s disease. Eastern J Med 18: 130-132, 2013."},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Shapiro JS. Does varicella-zoster virus infection of the peripheral ganglia cause Chronic Fatigue Syndrome? Med Hypotheses 73: 728-734, 2009.","DOI":"10.1016\/j.mehy.2009.04.043"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Goodman BP, Crepeau A, Dhawan PS, Khoury JA, Harris LA. Spectrum of autonomic nervous system impairment in Sjogren syndrome. Neurologist 22: 127-130, 2017.","DOI":"10.1097\/NRL.0000000000000134"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Yukawa S, Tahara K, Shoji A, Hayashi H, Tsuboi N. Acute pan-dysautonomia as well as central nervous system involvement and peripheral neuropathies in a patient with systemic lupus erythematosus. Mod Rheumatol 18: 516-521, 2008.","DOI":"10.3109\/s10165-008-0087-3"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Casale R, Generini S, Luppi F, Pignone A, Matucci-Cerinic M. Pulse cyclophosphamide decreases sympathetic postganglionic activity, controls alveolitis, and normalizes vascular tone dysfunction (Raynaud&apos;s phenomenon) in a case of early systemic sclerosis. Arthritis Rheum 51: 665-669, 2004.","DOI":"10.1002\/art.20542"},{"key":"34","unstructured":"34. Syngle A, Verma I, Krishan P, Garg N, Syngle V. Disease-modifying anti-rheumatic drugs improve autonomic neuropathy in arthritis: DIANA study. Clin Rheumatol 34: 1233-1241, 2015."},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Gono T, Murata M, Kawaguchi Y, et al. Successful treatment for sympathetic storms in a patient with neuro-Beh\u00e7et&apos;s disease. Clin Rheumatol 28: 357-359, 2009.","DOI":"10.1007\/s10067-008-1070-2"},{"key":"36","unstructured":"36. Golden EP, Vernino S. Autoimmune autonomic neuropathies and ganglionopathies: epidemiology, pathophysiology, and therapeutic advances. Clin Auton Res 29: 277-288, 2019."},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Shutty B, Garg KJ, Swender D, Chernin L, Tcheurekdjian H, Hostoffer R. Optimal use of ivig in a patient with Beh\u00e7et syndrome and common variable immunodeficiency. Ann Allergy Asthma Immunol 109: 84, 2012.","DOI":"10.1016\/j.anai.2012.05.014"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Seider N, Beiran I, Scharf J, Miller B. Intravenous immunoglobulin therapy for resistant ocular Beh\u00e7et&apos;s disease. Br J Ophthalmol 85: 1287-1288, 2001.","DOI":"10.1136\/bjo.85.11.1287"},{"key":"39","unstructured":"39. Cantarini L, Stromillo ML, Vitale A, et al. Efficacy and safety of intravenous immunoglobulin treatment in refractory Beh\u00e7et&apos;s disease with different organ involvement: a case series. Isr Med Assoc J 18: 238-242, 2016."}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/59\/8\/59_3954-19\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:07:39Z","timestamp":1695686859000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/59\/8\/59_3954-19\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,15]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.3954-19","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,15]]}}}