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Moriyama T, Nishii R, Perez-Andreu V, et al. NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity. Nat Genet 48: 367-373, 2016.","DOI":"10.1038\/ng.3508"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Valerie NC, Hagenkort A, Page BD, et al. NUDT15 hydrolyzes 6-thio-deoxyGTP to mediate the anticancer efficacy of 6-thioguanine. Cancer Res 76: 5501-5511, 2016.","DOI":"10.1158\/0008-5472.CAN-16-0584"},{"key":"3","unstructured":"3. Kakuta Y, Kawai Y, Okamoto D, et al. NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study. J Gastroenterol 53: 1065-1078, 2018."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Yang SK, Hong M, Baek J, et al. A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia. Nat Genet 46: 1017-1020, 2014.","DOI":"10.1038\/ng.3060"},{"key":"5","unstructured":"5. Chao K, Wang X, Cao Q, et al. Combined detection of NUDT15 variants could highly predict thiopurine-induced leukopenia in Chinese patients with inflammatory bowel disease: a multicenter analysis. Inflamm Bowel Dis 23: 1592-1599, 2017."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Fan X, Yin D, Men R, Xu H, Yang L. NUDT15 polymorphism confer increased susceptibility to thiopurine-induced leukopenia in patients with autoimmune hepatitis and related cirrhosis. Front Pharmacol 10: 346, 2019.","DOI":"10.3389\/fphar.2019.00346"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Kakuta Y, Izumiyama Y, Okamoto D, et al. High-resolution melt analysis enables simple genotyping of complicated polymorphisms of codon 18 rendering the NUDT15 diplotype. J Gastroenterol 55: 67-77, 2020.","DOI":"10.1007\/s00535-019-01638-x"},{"key":"8","unstructured":"8. Tadaka S, Saigusa D, Motoike IN, et al. jMorp: Japanese Multi Omics Reference Panel. 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