{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T13:37:27Z","timestamp":1782999447097,"version":"3.54.5"},"reference-count":20,"publisher":"Japanese Society of Internal Medicine","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2005]]},"DOI":"10.2169\/internalmedicine.44.572","type":"journal-article","created":{"date-parts":[[2005,7,14]],"date-time":"2005-07-14T09:05:26Z","timestamp":1121331926000},"page":"572-577","source":"Crossref","is-referenced-by-count":50,"title":["Increase in Incidence of Elderly-onset Patients with Myasthenia Gravis in Nagano Prefecture, Japan"],"prefix":"10.2169","volume":"44","author":[{"given":"Masayuki","family":"MATSUDA","sequence":"first","affiliation":[{"name":"Third Department of Medicine, Shinshu University School of Medicine, Matsumoto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"DOHI-IIJIMA","sequence":"additional","affiliation":[{"name":"Third Department of Medicine, Shinshu University School of Medicine, Matsumoto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinori","family":"NAKAMURA","sequence":"additional","affiliation":[{"name":"Third Department of Medicine, Shinshu University School of Medicine, Matsumoto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"SEKIJIMA","sequence":"additional","affiliation":[{"name":"Third Department of Medicine, Shinshu University School of Medicine, Matsumoto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"MORITA","sequence":"additional","affiliation":[{"name":"Third Department of Medicine, Shinshu University School of Medicine, Matsumoto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeyuki","family":"MATSUZAWA","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Shinshu University School of Medicine, Matsumoto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun-ichi","family":"SATO","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nagano Red Cross Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"YAHIKOZAWA","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nagano Red Cross Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-ichi","family":"TABATA","sequence":"additional","affiliation":[{"name":"Department of Neurology, Saku Central Hospital, Usuda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohei","family":"YANAGAWA","sequence":"additional","affiliation":[{"name":"Department of Neurology, Iida Municipal Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-ichi","family":"IKEDA","sequence":"additional","affiliation":[{"name":"Third Department of Medicine, Shinshu University School of Medicine, Matsumoto"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Drachman DB. Myasthenia gravis. N Engl J Med <b>330<\/b>: 1797-1810, 1994.","DOI":"10.1056\/NEJM199406233302507"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Grob D, Brunner NG, Namba T. The natural course of myasthenia gravis and effect of therapeutic measures. Ann N Y Acad Sci <b>377<\/b>: 652-669, 1981.","DOI":"10.1111\/j.1749-6632.1981.tb33764.x"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Robertson NP, Deans J, Compston DAS. Myasthenia gravis: a population based epidemiological study in Cambridgeshire, England. J Neurol Neurosurg Psychiatry <b>65<\/b>: 492-496, 1998.","DOI":"10.1136\/jnnp.65.4.492"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Phillips LH 2nd, Torner JC, Anderson MS, Cox GM. The epidemiology of myasthenia gravis in central and western Virginia. Neurology <b>42<\/b>: 1888-1893, 1992.","DOI":"10.1212\/WNL.42.10.1888"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Phillips LH 2nd, Torner JC. Epidemiologic evidence for a changing natural history of myasthenia gravis. Neurology <b>47<\/b>: 1233-1238, 1996.","DOI":"10.1212\/WNL.47.5.1233"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Christensen PB, Jensen TS, Tsiropoulos I, et al. Incidence and prevalence of myasthenia gravis in western Denmark: 1975 to 1989. Neurology <b>43<\/b>: 1779-1783, 1993.","DOI":"10.1212\/WNL.43.9.1779"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Schon F, Drayson M, Thompson RA. Myasthenia gravis and elderly people. Age Ageing <b>25<\/b>: 56-58, 1996.","DOI":"10.1093\/ageing\/25.1.56"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Jaretzki A 3rd, Barohn RJ, Ernstoff RM, et al. Myasthenia gravis. Recommendations for clinical research standards. Neurology <b>55<\/b>: 16-23, 2000.","DOI":"10.1212\/WNL.55.1.16"},{"key":"9","unstructured":"9) Oosterhuis HJGH. Diagnosis and differential diagnosis. in: Myasthenia Gravis. Baetes MH de, Oosterhuis HJGH, Ed. CRC Press, Boca Raton, 1994."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Hokkanen E. Epidemiology of myasthenia gravis in Finland. J Neurol Sci <b>9<\/b>: 463-478, 1969.","DOI":"10.1016\/0022-510X(69)90090-2"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Antonini G, Morino S, Gragnani F, Fiorelli M. Myasthenia gravis in the elderly: a hospital based study. Acta Neurol Scand <b>93<\/b>: 260-262, 1996.","DOI":"10.1111\/j.1600-0404.1996.tb00517.x"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Sorensen TT, Holm E-B. Myasthenia gravis in the country of Viborg, Denmark. Eur Neurol <b>29<\/b>: 177-179, 1989.","DOI":"10.1159\/000116405"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Chiu HC, Vincent A, Newsom-Davis J, Hsieh KH, Hung T. Myasthenia gravis: population difference in disease expression and acetylcholine receptor antibody titers between Chinese and Caucasians. Neurology <b>37<\/b>: 1854-1857, 1987 (Erratum in: Neurology <b>38<\/b>: 1504, 1988).","DOI":"10.1212\/WNL.37.12.1854"},{"key":"14","unstructured":"14) Statistics Bureau and Statistics Center. Kensei 2003 (Prefectural census in 2003). Nihon Kokusei Zue, Tokyo, 2002: 135-137 (in Japanese)."},{"key":"15","unstructured":"15) Statistics Bureau and Statistics Center. Kensei 2003 (Prefectural census in 2003). Nihon Kokusei Zue, Tokyo, 2002: 343 (in Japanese)."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Evoli A, Batocchi AP, Minisci C, Di Schino C, Tonali P. Clinical characteristics and prognosis of myasthenia gravis in older people. J Am Geriatr Soc <b>48<\/b>: 1442-1448, 2000.","DOI":"10.1111\/j.1532-5415.2000.tb02635.x"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Aarli JA. Late-onset myasthenia gravis: a changing scene. Arch Neurol <b>56<\/b>: 25-27, 1999.","DOI":"10.1001\/archneur.56.1.25"},{"key":"18","unstructured":"18) Newsom-Davis J, Vincent A, Willcox N. Acethylcholine receptor antibody: clinical and experimental aspects. in: Receptors, Antibodies and Disease: Chiba Foundation Symposium 90. Pitman Books Ltd, London, 1982: 225-247."},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Limburg PC, The TH, Hummel-Tappel E, Oosterhuis HJ. Anti-acethylcholine receptor antibodies in myasthenia gravis. Part I, relation to clinical parameters in 250 patients. J Neurol Sci <b>58<\/b>: 357-370, 1983.","DOI":"10.1016\/0022-510X(83)90095-3"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Compston DA, Vincent A, Newsom-Davis J, Batchelor JR. Clinical, pathological, HLA antigen and immunological evidence for disease heterogeneity in myasthenia gravis. Brain <b>103<\/b>: 579-601, 1980.","DOI":"10.1093\/brain\/103.3.579"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/44\/6\/44_6_572\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T21:13:30Z","timestamp":1497647610000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/44\/6\/44_6_572\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.44.572","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}