{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T15:38:35Z","timestamp":1776958715049,"version":"3.51.4"},"reference-count":28,"publisher":"Japanese Society of Internal Medicine","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2025,6,1]]},"DOI":"10.2169\/internalmedicine.4476-24","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T22:11:52Z","timestamp":1731017512000},"page":"1756-1760","source":"Crossref","is-referenced-by-count":1,"title":["Garcin Syndrome in a Patient with Hypertrophic Pachymeningitis Following Otitis Media with Antineutrophil Cytoplasmic Antibody (ANCA)-associated Vasculitis (OMAAV)"],"prefix":"10.2169","volume":"64","author":[{"given":"Naoya","family":"Nishimura","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Hamanomachi Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shotaro","family":"Kawano","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hamanomachi Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Tamae","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Hamanomachi Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Yoshizawa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hamanomachi Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"publisher","unstructured":"1. Harabuchi Y, Kishibe K, Tateyama K, et al. Clinical characteristics, the diagnostic criteria and management recommendation of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV) proposed by Japan Otological Society. Auris Nasus Larynx 48: 2-14, 2021.","DOI":"10.1016\/j.anl.2020.07.004"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Harabuchi Y, Kishibe K, Tateyama K, et al. Clinical features and treatment outcomes of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV): a retrospective analysis of 235 patients from a nationwide survey in Japan. Mod Rheumatol 27: 87-94, 2017.","DOI":"10.1080\/14397595.2016.1177926"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Ono N, Yoshihiro K, Oryoji D, et al. Four cases of MPO-ANCA-positive vasculitis with otitis media, and review of the literature. Mod Rheumatol 23: 554-563, 2013.","DOI":"10.3109\/s10165-012-0682-1"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Takahashi H, Tsuboi H, Umeda N, et al. A case of otitis media with ANCA-associated vasculitis accompanied with pituitary mass successfully treated by corticosteroids. Mod Rheumatol Case Rep 2: 185-190, 2018.","DOI":"10.1080\/24725625.2018.1433003"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Nakamura K, Hattori K, Nishiwaki A, et al. Otitis media with antineutrophil cytoplasmic antibody-associated vasculitis caused by Eustachian tube inflammation. Mod Rheumatol Case Rep 2: 191-194, 2018.","DOI":"10.1080\/24725625.2018.1466677"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Tabei A, Sakairi T, Ohishi Y, et al. Otitis media with ANCA-associated vasculitis: a retrospective study of 30 patients. Mod Rheumatol 32: 923-929, 2022.","DOI":"10.1093\/mr\/roab078"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Imafuku A, Sawa N, Kawada M, et al. Incidence and risk factors of new-onset hypertrophic pachymeningitis in patients with anti-neutrophil antibody-associated vasculitis: using logistic regression and classification tree analysis. Clin Rheumatol 38: 1039-1046, 2019.","DOI":"10.1007\/s10067-018-4372-z"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Tabari A, Farrokh F, Zeinalizadeh M, et al. Skull base osteomyelitis: a case report of Garcin syndrome due to mucormycosis in COVID pandemic. IDCases 33: e01827, 2023.","DOI":"10.1016\/j.idcr.2023.e01827"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Fujii M, Kiura K, Takigawa N, et al. Presentation of Garcin syndrome due to lung cancer. J Thorac Oncol 2: 877-878, 2007.","DOI":"10.1097\/JTO.0b013e31811f473d"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Terasaki K, Mizuno C, Fujiishi S, et al. Garcin syndrome due to meningeal carcinomatosis from gastric cancer. Intern Med 60: 855-858, 2021.","DOI":"10.2169\/internalmedicine.5797-20"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Nishida K, Takenaka Y, Yamasaki H, Futamura N. Garcin syndrome in a patient with neurolymphomatosis. Neurology 97: 600-601, 2021.","DOI":"10.1212\/WNL.0000000000012485"},{"key":"12","doi-asserted-by":"publisher","unstructured":"12. Kupersmith MJ, Martin V, Heller G, Shah A, Mitnick HJ. Idiopathic hypertrophic pachymeningitis. Neurology 62: 686-694, 2004.","DOI":"10.1212\/01.WNL.0000113748.53023.B7"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Mori A, Hira KI, Hatano T, et al. Bilateral facial nerve palsy due to otitis media associated with myeloperoxidase-antineutrophil cytoplasmic antibody. Am J Med Sci 346: 240-243, 2013.","DOI":"10.1097\/MAJ.0b013e318288371f"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Hellmich B, Sanchez-Alamo B, Schirmer JH, et al. EULAR recommendations for the management of ANCA-associated vasculitis: 2022 update. Ann Rheum Dis 83: 30-47, 2024.","DOI":"10.1136\/ard-2022-223764"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Yates M, Watts RA, Bajema IM, et al. EULAR\/ERA-EDTA recommendations for the management of ANCA-associated vasculitis. Ann Rheum Dis 75: 1583-1594, 2016.","DOI":"10.1136\/annrheumdis-2016-209133"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Okada M, Suemori K, Takagi D, et al. The treatment outcomes of rituximab for intractable otitis media with ANCA-associated vasculitis. Auris Nasus Larynx 46: 38-42, 2019.","DOI":"10.1016\/j.anl.2018.05.011"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Komagata Y, Nomura K, Yoshihara K, et al. AP-VAS 2012 case report: MPO-ANCA-negative relapse of MPO-ANCA-associated vasculitis. CEN Case Rep 2: 180-183, 2013.","DOI":"10.1007\/s13730-013-0100-3"},{"key":"18","unstructured":"18. Seo P, Specks U, Keogh KA. Efficacy of rituximab in limited Wegener&apos;s granulomatosis with refractory granulomatous manifestations. J Rheumatol 35: 2017-2023, 2008."},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Ooka S, Maeda A, Ito H, Omata M, Yamada H, Ozaki S. Treatment of refractory retrobulbar granuloma with rituximab in a patient with ANCA-negative Wegener&apos;s granulomatosis: a case report. Mod Rheumatol 19: 80-83, 2009.","DOI":"10.3109\/s10165-008-0119-z"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Shah S, Hruskova Z, Segelmark M, et al. Treatment of severe renal disease in ANCA positive and negative small vessel vasculitis with rituximab. Am J Nephrol 41: 296-301, 2015.","DOI":"10.1159\/000431336"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Kimura K, Fujii Y, Maekawa M, Tsukamoto H. Successful rituximab treatment in a patient with ANCA-negative granulomatosis with polyangitis: a case report. Mod Rheumatol Case Rep 6: 93-96, 2022.","DOI":"10.1093\/mrcr\/rxab034"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Andrade MM, Fernandes M, Freire S, Cruz D. Limited antineutrophil cytoplasmic antibodies (ANCA)-negative granulomatosis with polyangiitis: successful response to rituximab. Cureus 15: e41826, 2023.","DOI":"10.7759\/cureus.41826"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Roth AJ, Ooi JD, Hess JJ, et al. Epitope specificity determines pathogenicity and detectability in ANCA-associated vasculitis. J Clin Invest 123: 1773-1783, 2013.","DOI":"10.1172\/JCI65292"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Wilde B, Thewissen M, Damoiseaux J, van Paassen P, Witzke O, Tervaert JWC. T cells in ANCA-associated vasculitis: what can we learn from lesional versus circulating T cells? Arthritis Res Ther 12: 204, 2010.","DOI":"10.1186\/ar2923"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. M\u00e9let J, Mulleman D, Goupille P, Ribourtout B, Watier H, Thibault G. Rituximab-induced T cell depletion in patients with rheumatoid arthritis: association with clinical response. Arthritis Rheum 65: 2783-2790, 2013.","DOI":"10.1002\/art.38107"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Tokunaga M, Fujii K, Saito K, et al. Down-regulation of CD40 and CD80 on B cells in patients with life-threatening systemic lupus erythematosus after successful treatment with rituximab. Rheumatology (Oxford) 44: 176-182, 2005.","DOI":"10.1093\/rheumatology\/keh443"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Wierzbicka M, Szyfter W, Puszczewicz M, Borucki \u0141, Bartochowska A. Otologic symptoms as initial manifestation of Wegener granulomatosis: diagnostic dilemma. Otol Neurotol 32: 996-1000, 2011.","DOI":"10.1097\/MAO.0b013e31822558fd"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Yoshida N, Iino Y. Pathogenesis and diagnosis of otitis media with ANCA-associated vasculitis. Allergol Int 63: 523-532, 2014.","DOI":"10.2332\/allergolint.14-RAI-0774"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/64\/11\/64_4476-24\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T04:39:30Z","timestamp":1749271170000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/64\/11\/64_4476-24\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,1]]},"references-count":28,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.4476-24","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,1]]},"article-number":"4476-24"}}