{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T04:01:10Z","timestamp":1751774470720,"version":"3.41.0"},"reference-count":17,"publisher":"Japanese Society of Internal Medicine","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2025,7,1]]},"DOI":"10.2169\/internalmedicine.4566-24","type":"journal-article","created":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T22:13:58Z","timestamp":1735164838000},"page":"2042-2045","source":"Crossref","is-referenced-by-count":0,"title":["Rapid Emergence of Small-cell Carcinoma Due to Malignant Transformation or &lt;i&gt;de novo&lt;\/i&gt; Formation in the Anterior Mediastinum Following Thymoma Resection: The Importance of a Re-biopsy"],"prefix":"10.2169","volume":"64","author":[{"given":"Yasumiko","family":"Jodai","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Faculty of Life Sciences, Kumamoto University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Saruwatari","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Faculty of Life Sciences, Kumamoto University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Muramoto","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Faculty of Life Sciences, Kumamoto University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Imamura","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Faculty of Life Sciences, Kumamoto University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Sakata","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Faculty of Life Sciences, Kumamoto University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chieko","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Faculty of Life Sciences, Kumamoto University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Miyasato","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Kumamoto University Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumi","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Kumamoto University Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Tomita","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Faculty of Life Sciences, Kumamoto University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenori","family":"Ichiyasu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Faculty of Life Sciences, Kumamoto University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuro","family":"Sakagami","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Faculty of Life Sciences, Kumamoto University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Scorsetti M, Leo F, Trama A, et al. Thymoma and thymic carcinomas. Crit Rev Oncol Hematol 99: 332-350, 2016.","DOI":"10.1016\/j.critrevonc.2016.01.012"},{"key":"2","unstructured":"2. In: WHO Classification of Tumours. 5th ed. WHO Classification of Tumours Editorial Board, Ed. Thoracic Tumours. International Agency for Research on Cancer, Lyon, 2021."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Kuo TT, Chan JK. Thymic carcinoma arising in thymoma is associated with alterations in immunohistochemical profile. Am J Surg Pathol 22: 1474-1481, 1998.","DOI":"10.1097\/00000478-199812000-00004"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Ohue Y, Matsuoka S, Kumeda H, et al. Development of combined thymic carcinoma and thymoma in an extrathymic lesion during long follow-up for recurrent thymoma. Mol Clin Oncol 4: 139-142, 2016.","DOI":"10.3892\/mco.2015.708"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Pai CP, Lin CM, Yeh YC, Huang CS, Huang BS. De novo thymic carcinoma or malignant transformation: a myasthenic patient presented with multiple mediastinal tumours. Respirol Case Rep 8: e00629, 2020.","DOI":"10.1002\/rcr2.629"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Str\u00f6bel P, Zettl A, Shilo K, et al. Tumor genetics and survival of thymic neuroendocrine neoplasms: a multi-institutional clinicopathologic study. Genes Chromosomes Cancer 53: 738-749, 2014.","DOI":"10.1002\/gcc.22183"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Cardillo G, Treggiari S, Paul MA, et al. Primary neuroendocrine tumours of the thymus: a clinicopathologic and prognostic study in 19 patients. Eur J Cardio-thoracic Surg 37: 814-818, 2010.","DOI":"10.1016\/j.ejcts.2009.10.026"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Moran CA, Suster S. Thymic neuroendocrine carcinomas with combined features ranging from well-differentiated (carcinoid) to small cell carcinoma. A clinicopathologic and immunohistochemical study of 11 cases. Am J Clin Pathol 113: 345-350, 2000.","DOI":"10.1309\/Q01U-60BL-VEV4-TWR1"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Okumura M, Yoshino I, Funaki S, et al. Long-term outcomes following surgical treatment for thymic epithelial tumor in Japan and an analysis of prognostic factors based on the Japanese Association for Research on the Thymus nationwide database. Surg Today 53: 1247-1259, 2023.","DOI":"10.1007\/s00595-023-02705-w"},{"key":"10","doi-asserted-by":"crossref","unstructured":"11. Tsuji T, Ikeda H, Tsuchikawa T, et al. Malignant transformation of thymoma in recipient rats by heterotopic thymus transplantation from HTLV-I transgenic rats. Lab Invest 85: 851-861, 2005.","DOI":"10.1038\/labinvest.3700292"},{"key":"11","doi-asserted-by":"crossref","unstructured":"12. Filosso PL, Yao X, Ahmad U, et al; the European Society of Thoracic Surgeons Thymic Group Steering Committee. Outcome of primary neuroendocrine tumors of the thymus: a joint analysis of the International Thymic Malignancy Interest Group and the European Society of Thoracic Surgeons databases. J Thorac Cardiovasc Surg 149: 103-109.e102, 2015.","DOI":"10.1016\/j.jtcvs.2014.08.061"},{"key":"12","doi-asserted-by":"crossref","unstructured":"13. Dinter H, Bohnenberger H, Beck J, et al. Molecular classification of neuroendocrine tumors of the thymus. J Thorac Oncol 14: 1472-1483, 2019.","DOI":"10.1016\/j.jtho.2019.04.015"},{"key":"13","doi-asserted-by":"crossref","unstructured":"14. Guan Y, Yao Q, Hao Y, et al. The combination of etoposide and platinum for the treatment of thymic neuroendocrine neoplasms: a retrospective analysis. Cancer Med 12: 16011-16018, 2023.","DOI":"10.1002\/cam4.6245"},{"key":"14","doi-asserted-by":"crossref","unstructured":"15. Igawa S, Murakami H, Yamamoto N. Thymic small cell carcinoma shows marked response to amrubicin. J Thorac Oncol 4: 778, 2009.","DOI":"10.1097\/JTO.0b013e3181a52e74"},{"key":"15","doi-asserted-by":"crossref","unstructured":"16. Hirai F, Yamanaka T, Taguchi K, et al; the West Japan Oncology Group. A multicenter phase II study of carboplatin and paclitaxel for advanced thymic carcinoma: WJOG4207L. Ann Oncol 26: 363-368, 2015.","DOI":"10.1093\/annonc\/mdu541"},{"key":"16","unstructured":"17. National Comprehensive Cancer Network. Thymous and Thymic Carcinoma (Version 1.2024). National Comprehensive Cancer Network [Internet]. [cited 2024 May 31]. Available from: https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/thymic.pdf."},{"key":"17","doi-asserted-by":"crossref","unstructured":"18. Thomas P, Castelnau O, Paillotin D, et al. Phase II trial of paclitaxel and carboplatin in metastatic small-cell lung cancer: a Groupe Fran\u00e7ais de Pneumo-Canc\u00e9rologie study. J Clin Oncol 19: 1320-1325, 2001.","DOI":"10.1200\/JCO.2001.19.5.1320"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/64\/13\/64_4566-24\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T03:46:18Z","timestamp":1751687178000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/64\/13\/64_4566-24\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":17,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.4566-24","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"type":"print","value":"0918-2918"},{"type":"electronic","value":"1349-7235"}],"subject":[],"published":{"date-parts":[[2025,7,1]]},"article-number":"4566-24"}}