{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:01:17Z","timestamp":1792425677619,"version":"4.5.0"},"reference-count":32,"publisher":"Japanese Society of Internal Medicine","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2025,10,1]]},"DOI":"10.2169\/internalmedicine.4657-24","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T18:09:36Z","timestamp":1744394976000},"page":"2907-2912","source":"Crossref","is-referenced-by-count":3,"title":["Disseminated Fusariosis Successfully Treated with Empirical Liposomal Amphotericin B and Voriconazole Combination Followed by Ocular Therapy in an Allogenic Hematopoietic Stem Cell Transplant Recipient"],"prefix":"10.2169","volume":"64","author":[{"given":"Yuya","family":"Kishida","sequence":"first","affiliation":[{"name":"Department of Hematology, Nippon Medical School, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Sakaguchi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nippon Medical School, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Kunishige","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nippon Medical School, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Takeyoshi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nippon Medical School, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taichiro","family":"Tokura","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nippon Medical School, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Inai","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nippon Medical School, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nippon Medical School, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Ibaraki","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nippon Medical School, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nippon Medical School, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Asayama","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nippon Medical School, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Yui","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nippon Medical School, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Wakita","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nippon Medical School, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nippon Medical School, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Elvers KT, Leeming K, Moore CP, Lappin-Scott HM. Bacterial-fungal biofilms in flowing water photo-processing tanks. J Appl Microbiol 84: 607-618, 1998.","DOI":"10.1046\/j.1365-2672.1998.00388.x"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Al-Hatmi AMS, Bonifaz A, Ranque S, de Hoog GS, Verweij PE, Meis JF. Current antifungal treatment of fusariosis. Int J Antimicrob Agents 51: 326-332, 2018.","DOI":"10.1016\/j.ijantimicag.2017.06.017"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Pujol I, Guarro J, Gen\u00e9 J, Sala J. In-vitro antifungal susceptibility of clinical and environmental <i>Fusarium<\/i> spp. strains. J Antimicrob Chemother 39: 163-167, 1997.","DOI":"10.1093\/jac\/39.2.163"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Garnica M, da Cunha MO, Portugal R, Maiolino A, Colombo AL, Nucci M. Risk factors for invasive fusariosis in patients with acute myeloid leukemia and in hematopoietic cell transplant recipients. Clin Infect Dis 60: 875-880, 2015.","DOI":"10.1093\/cid\/ciu947"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Nucci M, Barreiros G, Akiti T, Anaissie E, Nou\u00e9r SA. Invasive fusariosis in patients with hematologic diseases. J Fungi (Basel) 7: 815, 2021.","DOI":"10.3390\/jof7100815"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Nagler A, Rocha V, Labopin M, et al. Allogeneic hematopoietic stem-cell transplantation for acute myeloid leukemia in remission: comparison of intravenous busulfan plus cyclophosphamide (Cy) versus total-body irradiation plus Cy as conditioning regimen - a report from the acute leukemia working party of the European group for blood and marrow transplantation. J Clin Oncol 31: 3549-3556, 2013.","DOI":"10.1200\/JCO.2013.48.8114"},{"key":"7","doi-asserted-by":"publisher","unstructured":"7. Sorror ML, Maris MB, Storb R, et al. Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT. Blood 106: 2912-2919, 2005.","DOI":"10.1182\/blood-2005-05-2004"},{"key":"8","unstructured":"8. Rex JH, Ghannoum MA, Alexander BD, et al. M38-A2: Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi : Approved Standard. 2nd ed. CLSI, Wayne, PA, USA, 2008: 1-35."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Tortorano AM, Richardson M, Roilides E, et al. ESCMID and ECMM joint guidelines on diagnosis and management of hyalohyphomycosis: <i>Fusarium<\/i> spp., <i>Scedosporium<\/i> spp. and others. Clin Microbiol Infect 20 (Suppl 3): 27-46, 2014.","DOI":"10.1111\/1469-0691.12465"},{"key":"10","unstructured":"10. Hoenigl M, Salmanton-Garc\u00eda J, Walsh TJ, et al. Global guideline for the diagnosis and management of rare mould infections: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology and the American Society for Microbiology. Lancet Infect Dis 21: e246-e257, 2021."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Nucci M, Anaissie E. <i>Fusarium<\/i> infections in immunocompromised patients. Clin Microbiol Rev 20: 695-704, 2007.","DOI":"10.1128\/CMR.00014-07"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Shono K. Disseminated <i>Fusarium solani<\/i> infection in patients undergoing hematopoietic stem cell transplantation. Nihon Ishinkin Gakkai Zasshi (Jpn J Med Mycol) 44: 187-191, 2003 (in Japanese).","DOI":"10.3314\/jjmm.44.187"},{"key":"13","unstructured":"13. Harada Y, Murata M, Matsumoto A, et al. Successful treatment of pre-engraftment disseminated fusariosis with high-dose liposomal amphotericin B in a cord blood transplant recipient. Rinsho Ketsueki (Jpn J Clin Hematol) 60: 1641-1646, 2019."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Wu CH, Lu PL, Hsiao HH, et al. Breakthrough <i>Fusarium solani<\/i> infection in a patient with acute myeloid leukemia receiving posaconazole prophylaxis. Ann Hematol 93: 1079-1081, 2014.","DOI":"10.1007\/s00277-013-1943-6"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Kassar O, Charfi M, Trabelsi H, Hammami R, Elloumi M. <i>Fusarium solani<\/i> endocarditis in an acute leukemia patient. Med Mal Infect 46: 57-59, 2016.","DOI":"10.1016\/j.medmal.2015.11.004"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Liu YS, Wang NC, Ye RH, Kao WY. Disseminated <i>Fusarium<\/i> infection in a patient with acute lymphoblastic leukemia: a case report and review of the literature. Oncol Lett 7: 334-336, 2014.","DOI":"10.3892\/ol.2013.1738"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Avelino-Silva VI, Ramos JF, Leal FE, Testagrossa L, Novis YS. Disseminated <i>Fusarium<\/i> infection in autologous stem cell transplant recipient. Braz J Infect Dis 19: 90-93, 2015.","DOI":"10.1016\/j.bjid.2014.08.009"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Cudillo L, Tendas A, Picardi A, et al. Successful treatment of disseminated fusariosis with high dose liposomal amphotericin-B in a patient with acute lymphoblastic leukemia. Ann Hematol 85: 136-138, 2006.","DOI":"10.1007\/s00277-005-0002-3"},{"key":"19","unstructured":"19. Muramatsu T, Ueki T, Ohashi K, et al. Successful treatment with voriconazole for disseminated cutaneous and visceral infection by <i>Fusarium solani<\/i> in a patient with acute myeloid leukemia. Rinsho Ketsueki (Jpn J Clin Hematol) 47: 753-757, 2006."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Rizzello I, Castagnetti F, Toschi PG, et al. Successful treatment of bilateral endogenous <i>Fusarium solani<\/i> endophthalmitis in a patient with acute lymphocytic leukaemia. Mycoses 61: 53-60, 2018.","DOI":"10.1111\/myc.12697"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Kapp M, Schargus M, Deuchert T, et al. Endophthalmitis as primary clinical manifestation of fatal fusariosis in an allogeneic stem cell recipient. Transpl Infect Dis 13: 374-379, 2011.","DOI":"10.1111\/j.1399-3062.2011.00608.x"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Sheela S, Ito S, Strich JR, et al. Successful salvage chemotherapy and allogeneic transplantation of an acute myeloid leukemia patient with disseminated <i>Fusarium solani<\/i> infection. Leuk Res Rep 8: 4-6, 2017.","DOI":"10.1016\/j.lrr.2017.07.001"},{"key":"23","unstructured":"23. Fujishita K, Oka S, Kamei K, et al. A Disseminated <i>Fusarium fujikuroi<\/i> species complex infection prior to allogeneic hematopoietic stem cell transplantation. Acta Med Okayama 74: 435-441, 2020."},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Fanci R, Pini G, Bartolesi AM, Pecile P. Refractory disseminated fusariosis by <i>Fusarium verticillioides<\/i> in a patient with acute myeloid leukaemia relapsed after allogeneic hematopoietic stem cell transplantation: a case report and literature review. Rev Iberoam Micol 30: 51-53, 2013.","DOI":"10.1016\/j.riam.2012.05.003"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Yu J, Chen Y, Fang J, Zhang K. Successful treatment of disseminated fusariosis in a patient with acute lymphoblastic leukemia: a case report and literature review.  Medicine (Baltimore) 98: e16246, 2019.","DOI":"10.1097\/MD.0000000000016246"},{"key":"26","unstructured":"26. Kurosawa S, Sekiya N, Muraosa Y, et al. Disseminated fusariosis in patients with acute leukemia: a retrospective analysis of three cases. Rinsho Ketsueki (Jpn J Clin Hematol) 58: 2375-2379, 2017."},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Yao YF, Feng J, Liu J, Chen CF, Yu B, Hu XP. Disseminated infection by <i>Fusarium solani<\/i> in acute lymphocytic leukemia: a case report. World J Clin Cases 9: 6443-6449, 2021.","DOI":"10.12998\/wjcc.v9.i22.6443"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Nucci M, Marr KA, Queiroz-Telles F, et al. <i>Fusarium<\/i> infection in hematopoietic stem cell transplant recipients. Clin Infect Dis 38: 1237-1242, 2004.","DOI":"10.1086\/383319"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Nucci M, Anaissie EJ, Queiroz-Telles F, et al. Outcome predictors of 84 patients with hematologic malignancies and <i>Fusarium<\/i> infection. Cancer 98: 315-319, 2003.","DOI":"10.1002\/cncr.11510"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Nucci M, Anaissie E. <i>Fusarium<\/i> infections in immunocompromised patients. Clin Microbiol Rev 20: 695-704, 2007.","DOI":"10.1128\/CMR.00014-07"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Raad II, Hachem RY, Herbrecht R, et al. Posaconazole as salvage treatment for invasive fusariosis in patients with underlying hematologic malignancy and other conditions. Clin Infect Dis 42: 1398-1403, 2006.","DOI":"10.1086\/503425"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Nucci M, Barreiros G, Reis H, Paix\u00e3o M, Akiti T, Nou\u00e9r SA. Performance of 1,3-beta-D-glucan in the diagnosis and monitoring of invasive fusariosis. Mycoses 62: 570-575, 2019.","DOI":"10.1111\/myc.12918"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/64\/19\/64_4657-24\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T03:20:24Z","timestamp":1759548024000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/64\/19\/64_4657-24\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":32,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.4657-24","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,1]]},"article-number":"4657-24"}}