{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:32:42Z","timestamp":1791772362640,"version":"4.3.4"},"reference-count":14,"publisher":"Japanese Society of Internal Medicine","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2025,8,1]]},"DOI":"10.2169\/internalmedicine.4708-24","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T17:11:41Z","timestamp":1738948301000},"page":"2312-2316","source":"Crossref","is-referenced-by-count":2,"title":["Anamorelin as a Therapeutic Option for Cancer Cachexia in Advanced Pancreatic Cancer: A Case Report Demonstrating Significant Weight Gain and Quality of Life Improvement"],"prefix":"10.2169","volume":"64","author":[{"given":"Motoyasu","family":"Kan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Chiba University, Japan"},{"name":"Department of Oncology, Graduate School of Medicine, Chiba University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Ogane","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Chiba University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Watabe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Chiba University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Chiba University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miho","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Chiba University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Sekine","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Chiba University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Chiba University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihei","family":"Sugihara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Chiba University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayu","family":"Ouchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Chiba University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Nagashima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Chiba University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Oncology, Graduate School of Medicine, Chiba University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Okitsu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Chiba University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ohyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Chiba University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izumi","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Oncology, Graduate School of Medicine, Chiba University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Chiba University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Argil\u00e9s JM, Busquets S, Stemmler B, L\u00f3pez-Soriano FJ. Cancer cachexia: understanding the molecular basis. Nat Rev Cancer 14: 754-762, 2014.","DOI":"10.1038\/nrc3829"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Mitsunaga S, Kasamatsu E, Machii K. Incidence and frequency of cancer cachexia during chemotherapy for advanced pancreatic ductal adenocarcinoma. Support Care Cancer 28: 5271-5279, 2020.","DOI":"10.1007\/s00520-020-05346-8"},{"key":"3","doi-asserted-by":"publisher","unstructured":"3. Katakami N, Uchino J, Yokoyama T, et al. Anamorelin (ONO-7643) for the treatment of patients with non-small cell lung cancer and cachexia: results from a randomized, double-blind, placebo-controlled, multicenter study of Japanese patients (ONO-7643-04). Cancer 124: 606-616, 2018.","DOI":"10.1002\/cncr.31128"},{"key":"4","doi-asserted-by":"publisher","unstructured":"4. Hamauchi S, Furuse J, Takano T, et al. A multicenter, open-label, single-arm study of anamorelin (ONO-7643) in advanced gastrointestinal cancer patients with cancer cachexia. Cancer 125: 4294-4302, 2019.","DOI":"10.1002\/cncr.32406"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Evans WJ, Morley JE, Argil\u00e9s J, et al. Cachexia: a new definition. Clin Nutr 27: 793-799, 2008.","DOI":"10.1016\/j.clnu.2008.06.013"},{"key":"6","unstructured":"6. Tisdale MJ. Pathogenesis of cancer cachexia. J Support Oncol 1: 159-168, 2003."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Setiawan T, Sari IN, Wijaya YT, et al. Cancer cachexia: molecular mechanisms and treatment strategies. J Hematol Oncol 16: 54, 2023.","DOI":"10.1186\/s13045-023-01454-0"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Dewys WD, Begg C, Lavin PT, et al. Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group. Am J Med 69: 491-497, 1980.","DOI":"10.1016\/S0149-2918(05)80001-3"},{"key":"9","doi-asserted-by":"publisher","unstructured":"9. Ozola Zalite I, Zykus R, Francisco Gonzalez M, et al. Influence of cachexia and sarcopenia on survival in pancreatic ductal adenocarcinoma: a systematic review. Pancreatology 15: 19-24, 2015.","DOI":"10.1016\/j.pan.2014.11.006"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Garcia JM. What is next after anamorelin? Curr Opin Support Palliate Care 11: 266-271, 2017.","DOI":"10.1097\/SPC.0000000000000299"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Taniguchi J, Mikura S, da Silva Lopes K. The efficacy and safety of anamorelin for patients with cancer-related anorexia\/cachexia syndrome: a systematic review and meta-analysis. Sci Rep 13: 15257, 2023.","DOI":"10.1038\/s41598-023-42446-x"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Temel JS, Abernethy AP, Currow DC, et al. Anamorelin in patients with non-small-cell lung cancer and cachexia (ROMANA 1 and ROMANA 2): results from two randomised, double-blind, phase 3 trials. Lancet Oncol 17: 519-531, 2016.","DOI":"10.1016\/S1470-2045(15)00558-6"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Dobs AS, Boccia RV, Croot CC, et al. Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial. Lancet Oncol 14: 335-345, 2013.","DOI":"10.1016\/S1470-2045(13)70055-X"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Hickish T, Andre T, Wyrwicz L, et al. MABp1 as a novel antibody treatment for advanced colorectal cancer: a randomised, double-blind, placebo-controlled, phase 3 study. Lancet Oncol 18: 192-201, 2017.","DOI":"10.1016\/S1470-2045(17)30006-2"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/64\/15\/64_4708-24\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:15:38Z","timestamp":1754108138000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/64\/15\/64_4708-24\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,1]]},"references-count":14,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.4708-24","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,1]]},"article-number":"4708-24"}}