{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T10:48:28Z","timestamp":1784198908530,"version":"3.55.0"},"reference-count":21,"publisher":"Japanese Society of Internal Medicine","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2025,7,15]]},"DOI":"10.2169\/internalmedicine.4719-24","type":"journal-article","created":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T17:14:09Z","timestamp":1735146849000},"page":"2234-2239","source":"Crossref","is-referenced-by-count":2,"title":["Diffuse Large B-cell Lymphoma with a Multilobated Nuclear Morphology Harboring t(14;18)(q32;q21) and t(3;22)(q27;q11)"],"prefix":"10.2169","volume":"64","author":[{"given":"Masahiro","family":"Manabe","sequence":"first","affiliation":[{"name":"Department of Hematology, Osaka General Hospital of West Japan Railway Company, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Inano","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Osaka General Hospital of West Japan Railway Company, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuuji","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Osaka General Hospital of West Japan Railway Company, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Ryang","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Hematology, Osaka General Hospital of West Japan Railway Company, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","unstructured":"1. Rosenwald A, Barrans SL, Calaminici M, et al. Diffuse large B-cell lymphoma NOS. In: WHO Classification of Tumours, 5th Ed., Vol.11. Haematolymphoid Tumours. WHO Classification of Tumours Editorial Board, Ed. International Agency for Research on Cancer, Lyon, 2024: 463-472."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Siebert R, Aukema SM. Mature B- and T-cell neoplasms and Hodgkin lymphoma. In: Cancer Cytogenetics: Chromosomal and Molecular Genetic Aberrations of Tumor Cells. 4th ed. Heim S, Mitelman F, Eds. Wiley Blackwell, Hoboken, 2015: 252-331.","DOI":"10.1002\/9781118795569.ch11"},{"key":"3","unstructured":"3. Mitelman F, Johansson B, Mertens F, Ed. Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer [Internet]. [cited 2024 Sep 17]. Available from: https:\/\/mitelmandatabase.isb-cgc.org."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Wong E, Juneja S. Diffuse large B-cell lymphoma in leukemic phase with flower cell morphology. Blood 123: 3378, 2014.","DOI":"10.1182\/blood-2014-03-559088"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Singh N, Gandhi J, Agrawal N, Panaych A, Tejwani N, Mehta A. Diagnostic dilemma in the morphological detection of flower cells in lymphomas. Indian J Hematol Blood Transfus 33: 614-616, 2017.","DOI":"10.1007\/s12288-017-0782-3"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Hwang CS, Hwang DG, Aboulafia DM. A clinical triad with fatal implications: recrudescent diffuse large B-cell non-Hodgkin lymphoma presenting in the leukemic phase with an elevated serum lactic acid level and dysregulation of the TP53 tumor suppressor gene - a case report and literature review. Clin Med Insights Blood Disord 14: 2634853521994094, 2021.","DOI":"10.1177\/2634853521994094"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Rold\u00e1n Galiacho V, Gallardo PZ, Zaldumbide Due\u00f1as L, De Las Fuentes BD, Garc\u00eda-Ruiz JC. Flower-shaped lymphocytes in CD5+ diffuse large B-cell lymphoma&apos;s leukemic phase. Blood Res 58: 165, 2023.","DOI":"10.5045\/br.2023.2023178"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Delhommeau F, Huguet S, Gachet J, van den Akker J, Lagrange M. Primary plasma cell leukemia mimicking an adult T-cell leukemia-lymphoma: a case report. Acta Cytol 54: 187-189, 2010.","DOI":"10.1159\/000325006"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Shibusawa M. Plasma cell leukaemia presenting as flower-shaped plasma cells mimicking adult T-cell leukaemia or lymphoma. Lancet Haematol 7: e270, 2020.","DOI":"10.1016\/S2352-3026(20)30037-5"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. De Miguel S\u00e1nchez C, Robles de Castro D, Pis\u00f3n Herrero C, P\u00e9rez Persona E, Salcedo Cuesta L, Guinea de Castro JM. Primary plasma cell leukaemia presenting with flower-shaped nuclei. Br J Haematol 193: 689, 2021.","DOI":"10.1111\/bjh.17320"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Sall A, Seck M, Samb D, et al. Flower-like plasma cell nuclei in multiple myeloma. Turk J Haematol 38: 153-154, 2021.","DOI":"10.4274\/tjh.galenos.2020.2020.0471"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Ito A, Miyaoka M, Tomita S, et al. The multilobated morphology is still a better prognosis factor of diffuse large B-cell lymphoma in the R-CHOP era. Pathol Int 72: 550-557, 2022.","DOI":"10.1111\/pin.13280"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Jujo T, Sakurai T, Sakao S, Tatsumi K. Cell blocks used to diagnose primary effusion lymphoma-like lymphoma. Intern Med 53: 335-336, 2014.","DOI":"10.2169\/internalmedicine.53.1584"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Huang K, Zhou L, Tong Y. Cell-Block cytology in diagnosis of primary central nervous system lymphoma: a case report. Medicine (Baltimore) 99: e19598, 2020.","DOI":"10.1097\/MD.0000000000019598"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Yoshino A, Ishida S, Nakamura S, et al. Use of liquid-based cytology and cell block combined technique for an accurate diagnosis of oral diffuse large B cell lymphoma: a case report. Diagnostics (Basel) 10: 823, 2020.","DOI":"10.3390\/diagnostics10100823"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Antillon F, Behm FG, Raimondi SC, Kaste SC, Sandlund JT, Pappo AS. Pediatric primary diffuse large cell lymphoma of bone with t(3;22)(q27;q11). J Pediatr Hematol Oncol 20: 552-555, 1998.","DOI":"10.1097\/00043426-199811000-00008"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Sanchez-Izquierdo D, Siebert R, Harder L, et al. Detection of translocations affecting the BCL6 locus in B cell non-Hodgkin&apos;s lymphoma by interphase fluorescence in situ hybridization. Leukemia 15: 1475-1484, 2001.","DOI":"10.1038\/sj.leu.2402207"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Fujimoto Y, Nomura K, Fukada S, et al. Immunoglobulin light chain gene translocations in non-Hodgkin&apos;s lymphoma as assessed by fluorescence in situ hybridisation. Eur J Haematol 80: 143-150, 2008.","DOI":"10.1111\/j.1600-0609.2007.00993.x"},{"key":"19","doi-asserted-by":"publisher","unstructured":"19. Johnson NA, Savage KJ, Ludkovski O, et al. Lymphomas with concurrent BCL2 and MYC translocations: the critical factors associated with survival. Blood 114: 2273-2279, 2009.","DOI":"10.1182\/blood-2009-03-212191"},{"key":"20","unstructured":"20. Hebert J, Romana SP, Hillion J, Kerkaert JP, Bastard C, Berger R. Translocation t(3;22)(q27;q11) in non-Hodgkin&apos;s malignant lymphoma: chromosome painting and molecular studies. Leukemia 7: 1971-1974, 1993."},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Lin P, Jetly R, Lennon PA, Abruzzo LV, Prajapati S, Medeiros LJ. Translocation (18;22)(q21;q11) in B-cell lymphomas: a report of 4 cases and review of the literature. Hum Pathol 39: 1664-1672, 2008.","DOI":"10.1016\/j.humpath.2008.04.007"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/64\/14\/64_4719-24\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T03:50:39Z","timestamp":1752897039000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/64\/14\/64_4719-24\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,15]]},"references-count":21,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.4719-24","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,15]]},"article-number":"4719-24"}}