{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T01:29:58Z","timestamp":1774574998618,"version":"3.50.1"},"reference-count":14,"publisher":"Japanese Society of Internal Medicine","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2020,12,15]]},"DOI":"10.2169\/internalmedicine.4756-20","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T22:14:41Z","timestamp":1607984081000},"page":"3147-3154","source":"Crossref","is-referenced-by-count":13,"title":["Chronic Enteropathy Associated with &lt;i&gt;SLCO2A1&lt;\/i&gt; with Pachydermoperiostosis"],"prefix":"10.2169","volume":"59","author":[{"given":"Yoshikazu","family":"Tsuzuki","sequence":"first","affiliation":[{"name":"Department of General Internal Medicine, Saitama Medical University, Japan"},{"name":"Department of Gastroenterology, Saitama Medical University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryutaro","family":"Aoyagi","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, Saitama Medical University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Miyaguchi","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, Saitama Medical University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keigo","family":"Ashitani","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, Saitama Medical University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Ohgo","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, Saitama Medical University, Japan"},{"name":"Department of Gastroenterology, Saitama Medical University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Yamaoka","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, Saitama Medical University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Ishizawa","sequence":"additional","affiliation":[{"name":"Department of Pathology, Saitama Medical University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Kayano","sequence":"additional","affiliation":[{"name":"Department of Pathology, Saitama Medical University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadakazu","family":"Hisamatsu","sequence":"additional","affiliation":[{"name":"The Third Department of Internal Medicine, Kyorin University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junji","family":"Umeno","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science, Graduate School of Medical Science, Kyushu University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Hosoe","sequence":"additional","affiliation":[{"name":"Center for Diagnostic and Therapeutic Endoscopy, Keio University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetomo","family":"Nakamoto","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, Saitama Medical University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Imaeda","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, Saitama Medical University, Japan"},{"name":"Department of Gastroenterology, Saitama Medical University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"962","reference":[{"key":"1","unstructured":"1. Matsumoto T, Nakamura S, Esaki M, et al. Endoscopic features of chronic nonspecific multiple ulcers of the small intestine: comparison with nonsteroidal anti-inflammatory drug-induced enteropathy. Dig Dis Sci 51: 1357-1363, 2006."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Matsumoto T, Kubokura N, Matsui T, Iida M, Yao T. Chronic nonspecific multiple ulcer of the small intestine segregates in offspring from consanguinity. J Crohns Colitis 5: 559-565, 2011.","DOI":"10.1016\/j.crohns.2011.05.008"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Zhang Z, Xia W, He J, et al. Exome sequencing identifies <i>SLCO2A1<\/i> mutations as a cause of primary hypertrophic osteoarthropathy. Am J Hum Genet 90: 125-132, 2012.","DOI":"10.1016\/j.ajhg.2011.11.019"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Umeno J, Hisamatsu T, Esaki M, et al. A hereditary enteropathy caused by mutations in the <i>SLCO2A1<\/i> gene, encoding a prostaglandin transporter. PLoS Genet 11: e1005581, 2015.","DOI":"10.1371\/journal.pgen.1005581"},{"key":"5","unstructured":"5. Sun X, Hosoe N, Miyanaga R, et al. A male Korean who was diagnosed with chronic enteropathy associated with <i>SLCO2A1<\/i> (CEAS): case report with literature review. BMJ Open Gastroenterol 5: e000223-e000226, 2018."},{"key":"6","unstructured":"6. Umeno J, Esaki M, Hirano A, et al.; The CEAS study group. Clinical features of chronic enteropathy associated with <i>SLCO2A1<\/i> gene: a new entity clinically distinct from Crohn&apos;s disease. J Gastroenterol 53: 907-915, 2018."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Hosoe N, Ohmiya N, Hirai F, et al.; CEAS Atlas Group. Chronic enteropathy associated with <i>SLCO2A1<\/i> gene [CEAS]-characterization of an enteric disorder to be considered in the differential diagnosis of Crohn&apos;s disease. J Crohns Colitis 11: 1277-1281, 2017.","DOI":"10.1093\/ecco-jcc\/jjx068"},{"key":"8","unstructured":"8. Matsumoto T, Iida M, Matsui T, Yao T. Chronic nonspecific multiple ulcers of the small intestine: a proposal of the entity from Japanese gastroenterologists to Western enteroscopists. Gastrointest Endosc 66: S99-S107, 2007."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Esaki M, Umeno J, Kitazono T, Matsumoto T. Clinicopathologic features of chronic nonspecific multiple ulcers of the small intestine. Clin J Gastroenterol 8: 57-62, 2015.","DOI":"10.1007\/s12328-015-0559-x"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Yanai S, Yamaguchi S, Nakamura S, et al. Distinction between chronic enteropathy associated with the <i>SLCO2A1<\/i> gene and Crohn&apos;s disease. Gut Liver 13: 62-66, 2019.","DOI":"10.5009\/gnl18261"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Yuan L, Chen X, Liu Z, et al. Novel <i>SLCO2A1<\/i> mutations cause gender differentiated pachydermoperiostosis. Endocr Connec 7: 1116-1128, 2018.","DOI":"10.1530\/EC-18-0326"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Yamaguchi S, Yanai S, Nakamura S, et al. Immunohistochemical differentiation between chronic enteropathy associated with <i>SLCO2A1<\/i> gene and other inflammatory bowel diseases. Intest Res 16: 393-399, 2018.","DOI":"10.5217\/ir.2018.16.3.393"},{"key":"13","unstructured":"13. Uchida K, Nakajima A, Ushijima K, et al. Pediatric-onset chronic nonspecific multiple ulcers of small intestine: a nationwide survey and genetic study in Japan. J Pediatr Gastroenterol Nutr 64: 565-568, 2017."},{"key":"14","unstructured":"14. Eda K, Mizuochi T, Takaki Y, Ushijima K, Umeno J, Yamashita Y. Successful azathioprine treatment in an adolescent with chronic enteropathy associated with <i>SLCO2A1<\/i> gene: a case report. Medicine (Baltimore) 97: e12811-e12814, 2018."}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/59\/24\/59_4756-20\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T04:37:04Z","timestamp":1608352624000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/59\/24\/59_4756-20\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,15]]},"references-count":14,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.4756-20","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,15]]}}}