{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T10:21:41Z","timestamp":1767867701049,"version":"3.49.0"},"reference-count":33,"publisher":"Japanese Society of Internal Medicine","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2009]]},"DOI":"10.2169\/internalmedicine.48.2177","type":"journal-article","created":{"date-parts":[[2009,7,22]],"date-time":"2009-07-22T05:57:11Z","timestamp":1248242231000},"page":"1193-1199","source":"Crossref","is-referenced-by-count":27,"title":["The Effect of Ethinylestradiol (EE)\/Cyproterone Acetate (CA) and EE\/CA Plus Metformin Treatment on Adhesion Molecules in Cases with Polycystic Ovary Syndrome (PCOS)"],"prefix":"10.2169","volume":"48","author":[{"given":"Oktay","family":"Bilgir","sequence":"first","affiliation":[{"name":"Internal Medicine Division of Hematology, Bozyaka Training and Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levent","family":"Kebapcilar","sequence":"additional","affiliation":[{"name":"Internal Medicine, Division of Endocrinology and Metabolism, Bozyaka Training and Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuneyt","family":"Taner","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetric, Izmir Tepecik Gynecology and Obstetrics Research and Training Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferda","family":"Bilgir","sequence":"additional","affiliation":[{"name":"Internal Medicine, Buca State Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayse","family":"Kebapcilar","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetric, Izmir Tepecik Gynecology and Obstetrics Research and Training Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giray","family":"Bozkaya","sequence":"additional","affiliation":[{"name":"Biochemistry, Bozyaka Training and Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasar","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Internal Medicine, Bozyaka Training and Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arif","family":"Yuksel","sequence":"additional","affiliation":[{"name":"Internal Medicine, Bozyaka Training and Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail","family":"Sari","sequence":"additional","affiliation":[{"name":"Internal Medicine, Bozyaka Training and Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Alexander RW. Inflamation and coronary artery disease. N Eng J Med 331: 468-469, 1994.","DOI":"10.1056\/NEJM199408183310709"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Wilson PW, Kannel WB, Silbershatz H, et al. Clustering of metabolic factors and coronary heart disease. Arch Intern Med 159: 1104-1109, 1999.","DOI":"10.1001\/archinte.159.10.1104"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Lee CD, Folsom AR, Nieto FJ, et al. White blood cell count and incidence of coronary heart disease and ischemic stroke and mortality from cardiovascular disease in African-American and white men and women. Am J Epidemiol 154: 758-764, 2001.","DOI":"10.1093\/aje\/154.8.758"},{"key":"4","first-page":"1405","volume":"103","year":"2001","unstructured":"4. Paradisi G, Steinberg HO, Hempfling A, et al. Polycystic ovary syndrome is associated with endothelial dysfunction. Circulation 103: 1405-1410, 2001.","journal-title":"Circulation","ISSN":"https:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Moran LJ, Noakes M, Clifton PM, Wittert GA, Belobrajdic DP, Norman RJ. C-reactive protein before and after weight loss in overweight women with and without polycystic ovary syndrome. J Clin Endocrinol Metab 92: 2944-2951, 2007.","DOI":"10.1210\/jc.2006-2336"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Jakubowska J, Bohdanowicz-Pawlak A, Milewicz A, Szymczak J, Bednarek-Tupikowska G, Demissie M. Plasma cytokines in obese women with polycystic ovary syndrome, before and after metformin treatment. Gynecol Endocrinol 24: 378-384, 2008.","DOI":"10.1080\/09513590802128968"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Diamanti-Kandarakis E, Paterakis T, Alexandraki K, et al. Indices of low-grade chronic inflammation in polycystic ovary syndrome and the beneficial effect of metformin. Human Reproduc 21: 1426-1431, 2006.","DOI":"10.1093\/humrep\/del003"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. The Rotterdam ESHRE\/ASRM-sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 19: 41-47, 2004.","DOI":"10.1093\/humrep\/deh098"},{"key":"9","unstructured":"9. Zwirska-Korczala K, Sodowski K, Konturek SJ, et al. Postprandial response of ghrelin and pindices of low-grade chronic inflammation in lean young women with polycystic ovary syndrome. J Physiol Pharmacol 59 (Suppl 2): 161-178, 2008."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Heutling D, Schulz H, Nickel I, et al. Asymmetrical dimethylarginine, inflamatory and metabolic parameters in woman with polycystic ovary syndrome before and after metformin treatment. J Clin Endocrinol Metab 93: 82-90, 2008.","DOI":"10.1210\/jc.2007-0842"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Bahceci M, Tuzcu A, Canoruc N, et al. Serum C-reactive protein (CRP) levels and insulin resistance in non-obese women with polycystic ovary syndrome and effect of bicalutamide on hirsutism, CRP levels and insulin resistance. Horm Res 62: 283-287, 2004.","DOI":"10.1159\/000081973"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Escobar-Morreale HF, Botella-Carretero JI, Villuendas G, et al. Serum interleukin-18 concentrations are increased in the polycystic ovary syndrome: relationship to insulin resistance and to obesity. J Clin Endocrinol Metab 89: 806-811, 2004.","DOI":"10.1210\/jc.2003-031365"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Orio F Jr, Palomba S, Cascella T, et al. The increase of leucocytes as a new putative marker of low-grade chronic inflammation and early cardiovascular risk in polycystic ovary syndrome. J Clin Endocrinol Metab 90: 2-5, 2005.","DOI":"10.1210\/jc.2004-0628"},{"key":"14","unstructured":"14. De Jager J, Kooy A, Lehert PH, et al. Effects of short-term treatment with metformin on markers of endothelial function and inflamatory activity in type 2 diabetes mellitus: a randomized, placebo-controlled trial. J Intern Med 257: 100-109, 2005."},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Orio F Jr, Palomba S, Cascella T, et al. Improvement in endothelial structure and function after metformin treatment in young normal-weight women with polycystic ovary syndrome: results of a 6-month study. J Clin Endocrinol Metab 90: 6072-6076, 2005.","DOI":"10.1210\/jc.2005-0965"},{"key":"16","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1161\/01.CIR.93.4.672","volume":"93","year":"1996","unstructured":"16. O'Brain KD, McDonald TO, Chait A, et al. Neovascular expression of S E-selectin, intracellular adhesion molecule-1, and vascular adhesion molecule-1 in human atherosclerosis and their relation to intimal leucocyte content. Circulation 93: 672-682, 1996.","journal-title":"Circulation","ISSN":"https:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"key":"17","doi-asserted-by":"publisher","unstructured":"17. Katayama Y, Hidalgo A, Furie BC, et al. PSGL-1 partipicates in sE-selectin mediated progenitor homing to bone marrow: evidence for cooperation between sE-selectin ligands and alpha4 integrin. Blood 102: 2060-2067, 2003.","DOI":"10.1182\/blood-2003-04-1212"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Steegmaier M, Levinovitz A, Isenmann S, et al. The S E-selectin ligand ESL-1 is a variant of a receptor for fibroblast growth factor. Nature 373: 615-620, 1995.","DOI":"10.1038\/373615a0"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Isoda K, Young JL, Zirlik A, et al. Metformin inhibits proinflammatory responses and nuclear factor-kappaB in human vascular wall cells. Arterioscler Thromb Vasc Biol 26: 611-617, 2006.","DOI":"10.1161\/01.ATV.0000201938.78044.75"},{"key":"20","doi-asserted-by":"publisher","unstructured":"20. Hattori Y, Suzuki K, Hattori S, Kasai K. Metformin inhibits cytokine-induced nuclear factor kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells. Hypertension 47: 1183-1188, 2006.","DOI":"10.1161\/01.HYP.0000221429.94591.72"},{"key":"21","doi-asserted-by":"publisher","unstructured":"21. Ryysy L, Yki-Jarvinen H. Improvement of glycemic control by 1 year of insulin therapy leads to a sustained decrease in sE-selectin concentrations in type 2 diabetes. Diabetes Care 24: 549-554, 2001.","DOI":"10.2337\/diacare.24.3.549"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. De Jager J, Kooy A, Lehert P, et al. Effects of short-term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: a randomized, placebo-controlled trial. J Intern Med 257: 100-109, 2005.","DOI":"10.1111\/j.1365-2796.2004.01420.x"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Lund SS, Tarnow L, Stehouwer CD, et al. Impact of metformin versus repaglinide on non-glycaemic cardiovascular risk markers related to inflammation and endothelial dysfunction in non-obese patients with type 2 diabetes. Eur J Endocrinol 158: 631-641, 2008.","DOI":"10.1530\/EJE-07-0815"},{"key":"24","doi-asserted-by":"publisher","unstructured":"24. Abbasi F, Chu JW, McLaughlin T, Lamendola C, Leary ET, Reaven GM. Effect of metformin treatment on multiple cardiovascular disease risk factors in patients with type 2 diabetes mellitus. Metabolism 53: 159-164, 2004.","DOI":"10.1016\/j.metabol.2003.07.020"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Kautzky-Willer A, Tura A, Winzer C, et al. Insulin sensitivity during oral glucose tolerance test and its relations to parameters of glucose metabolism and endothelial function in type 2 diabetic subjects under metformin and thiazolidinedione. Diabetes Obes Metab 8: 561-567, 2006.","DOI":"10.1111\/j.1463-1326.2005.00568.x"},{"key":"26","doi-asserted-by":"publisher","unstructured":"26. Tatsumi H, Kitawaki J, Tanaka K, Hosoda T, Honjo H. Lack of stimulatory effect of dienogest on the expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 by endothelial cell as compared with other synthetic progestins. Maturitas 42: 287-294, 2002.","DOI":"10.1016\/S0378-5122(02)00157-3"},{"key":"27","doi-asserted-by":"publisher","unstructured":"27. Hemelaar M, van der Mooren MJ, van Baal WM, Schalkwijk CG, Kenemans P, Stehouwer CD. Effects of transdermal and oral postmenopausal hormone therapy on vascular function: a randomized, placebo-controlled study in healthy postmenopausal women. Menopause 12: 526-535, 2005.","DOI":"10.1097\/01.GME.0000153888.94399.AF"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Seeger H, Petersen G, Schulte-Wintrop E, Teichmann AT, Mueck AO. Effect of two oral contraceptives containing ethinylestradiol and levonorgestrel on serum and urinary surrogate markers of endothelial function. Int J Clin Pharmacol Ther 40: 150-157, 2002.","DOI":"10.5414\/CPP40150"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Kernohan AF, Spiers A, Sattar N, et al. Effects of low-dose continuous combined HRT on vascular function in women with type 2 diabetes. Diab Vasc Dis Res 1: 82-88, 2004.","DOI":"10.3132\/dvdr.2004.012"},{"key":"30","doi-asserted-by":"publisher","unstructured":"30. Goudev A, Georgiev D, Koycheva N, Manasiev N, Kyurkchiev S. Effects of low dose hormone replacement therapy on markers of inflammation in postmenopausal women. Maturitas 43: 49-53, 2002.","DOI":"10.1016\/S0378-5122(02)00182-2"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Farzati A, Esposito K, Colacurci N, Fornaro F, Chiantera V, Farzati B. Effects of transdermal hormone replacement therapy on levels of soluble P- and E-selectin in postmenopausal healthy women. Fertil Steril 77: 476-480, 2002.","DOI":"10.1016\/S0015-0282(01)03225-3"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Matsushita K, Yatsuya H, Tamakoshi K, et al. Comparison of circulating adiponectin and proinflammatory markers regarding their association with metabolic syndrome in Japanese men. Arterioscler Thromb Vasc Biol 26: 871-876, 2006.","DOI":"10.1161\/01.ATV.0000208363.85388.8f"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Nishida M, Moriyama T, Sugita Y, Yamauchi-Takihara K. Interleukin-10 associates with adiponectin predominantly in subjects with metabolic syndrome. Circ J 71: 1234-1238, 2007.","DOI":"10.1253\/circj.71.1234"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/48\/14\/48_14_1193\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T16:13:54Z","timestamp":1558455234000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/48\/14\/48_14_1193\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":33,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.48.2177","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}