{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:57:12Z","timestamp":1784674632706,"version":"3.55.0"},"reference-count":20,"publisher":"Japanese Society of Internal Medicine","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2025,9,15]]},"DOI":"10.2169\/internalmedicine.4822-24","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T18:14:40Z","timestamp":1741976080000},"page":"2692-2698","source":"Crossref","is-referenced-by-count":1,"title":["Usefulness of Repeated Lusutrombopag Administration in Clinical Practice and Its Correlation with the Simulation Software-Predicted Platelet Count: A Multicenter Study"],"prefix":"10.2169","volume":"64","author":[{"given":"Takushi","family":"Manabe","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Takamatsu Red Cross Hospital, Japan"},{"name":"Department of Gastroenterology and Neurology, Kagawa University Faculty of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikara","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Takamatsu Red Cross Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Tamada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Takatsuki Red Cross Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Japanese Red Cross Nagoya Daiichi Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiro","family":"Akahane","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Ishinomaki Red Cross Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Japanese Red Cross Society Kyoto Daiichi Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Maebashi Red Cross Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Takuma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Neurology, Kagawa University Faculty of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Nakahara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Neurology, Kagawa University Faculty of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Oura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Neurology, Kagawa University Faculty of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Tadokoro","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Neurology, Kagawa University Faculty of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Neurology, Kagawa University Faculty of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joji","family":"Tani","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Neurology, Kagawa University Faculty of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asahiro","family":"Morishita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Neurology, Kagawa University Faculty of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Kobara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Neurology, Kagawa University Faculty of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Himeji Red Cross Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironori","family":"Ochi","sequence":"additional","affiliation":[{"name":"Center for Liver-Biliary-Pancreatic Disease, Matsuyama Red Cross Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Takaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nami","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Kurosaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namiki","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Peck-Radosavljevic M. Thrombocytopenia in chronic liver disease. Liver Int 37: 778-793, 2017.","DOI":"10.1111\/liv.13317"},{"key":"2","unstructured":"2. SharmaNagalli AS, Nagalli S. Chronic Liver Disease [Internet]. [updated 2023; cited 2024 Jun 14]. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK554597\/"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Poordad F. Review article: thrombocytopenia in chronic liver disease. Aliment Pharmacol Ther 26: 5-11, 2007.","DOI":"10.1111\/j.1365-2036.2007.03510.x"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Chiem C, Alghamdi K, Nguyen T, et al. The impact of COVID-19 on blood transfusion services: a systematic review and meta-analysis. Transfus Med Hemoth 49: 107-118, 2022.","DOI":"10.1159\/000519245"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Alkhouri N, Imawari M, Izumi N, et al. Lusutrombopag is safe and efficacious for treatment of thrombocytopenia in patients with and without hepatocellular carcinoma. Clin Gastroenterol Hepatol 18: 2600-2608, 2020.","DOI":"10.1016\/j.cgh.2020.03.032"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Yoshiji H, Suzuki J, Imasaki M, et al. Safety and effectiveness of lusutrombopag in patients who have chronic liver disease with thrombocytopenia and undergoing invasive procedures: real-world post-marketing surveillance in Japan. Hepatol Res 53: 1105-1106, 2023.","DOI":"10.1111\/hepr.13945"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Nomoto H, Morimoto N, Miura K, et al. Lusutrombopag is effective and safe in patients with chronic liver disease and severe thrombocytopenia: a multicenter retrospective study. BMC Gastroenterol 20: 1-9, 2020.","DOI":"10.1186\/s12876-020-01573-9"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Ishikawa T, Okoshi M, Tomiyoshi K, et al. Efficacy and safety of repeated use of lusutrombopag prior to radiofrequency ablation in patients with recurrent hepatocellular carcinoma and thrombocytopenia. Hepatol Res 49: 590-593, 2019.","DOI":"10.1111\/hepr.13305"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Nishida Y, Kawaoka T, Imamura M, et al. Efficacy of lusutrombopag for thrombocytopenia in patients with chronic liver disease scheduled to undergo invasive procedures. Intern Med 60: 829-837, 2021.","DOI":"10.2169\/internalmedicine.5930-20"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Katsube T, Shimizu R, Fukuhara T, et al. Pharmacokinetic\/pharmacodynamic modelling and simulation of lusutrombopag, a novel thrombopoietin receptor agonist, for the treatment of thrombocytopenia in patients with chronic liver disease undergoing invasive procedures. Clin Pharmacokinet 58: 1469-1482, 2019.","DOI":"10.1007\/s40262-019-00770-4"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Kanda Y. Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Bone Marrow Transplant 48: 452-458, 2013.","DOI":"10.1038\/bmt.2012.244"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Yoshiji H, Ueno Y, Kurosaki M, et al. Treatment algorithm for thrombocytopenia in patients with chronic liver disease undergoing planned invasive procedures. Hepatol Res 51: 1181-1195, 2021.","DOI":"10.1111\/hepr.13715"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Nery F, Chevret S, Condat B, et al. Causes and consequences of portal vein thrombosis in 1,243 patients with cirrhosis: results of a longitudinal study. Hepatology 61: 660-667, 2015.","DOI":"10.1002\/hep.27546"},{"key":"14","doi-asserted-by":"publisher","unstructured":"14. Miki N, Inoue S, Shibahara H, et al. A cost-effectiveness analysis of lusutrombopag for thrombocytopenia in patients with chronic liver disease in Japan. JGH Open 5: 879-887, 2021.","DOI":"10.1002\/jgh3.12597"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Saab S, Brown RS. Management of thrombocytopenia in patients with chronic liver disease. Dig Dis Sci 64: 2757-2768, 2019.","DOI":"10.1007\/s10620-019-05615-5"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Vamvakas EC, Blajchman MA. Transfusion-related mortality: the ongoing risks of allogeneic blood transfusion and the available strategies for their prevention. Blood 113: 3406-3417, 2009.","DOI":"10.1182\/blood-2008-10-167643"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. McCullough J. Current issues with platelet transfusion in patients with cancer. Semin Hematol 37: 3-10, 2000.","DOI":"10.1016\/S0037-1963(00)90047-7"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Yoshida H, Ohki T, Kanezaki M, et al. A study on prevention of bleeding complications using lusutrombopag for safe RFA in patients with hepatocellular carcinoma with low platelet counts: prospective observational study. BMC Gastroenterol 23: 250, 2023.","DOI":"10.1186\/s12876-023-02879-0"},{"key":"19","doi-asserted-by":"publisher","unstructured":"19. Peck-Radosavljevic M, Simon K, Iacobellis A, et al. Lusutrombopag for the treatment of thrombocytopenia in patients with chronic liver disease undergoing invasive procedures (L-PLUS 2). Hepatology 70: 1336-1348, 2019.","DOI":"10.1002\/hep.30561"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Afdhal NH, Giannini EG, Tayyab G, et al. Eltrombopag before procedures in patients with cirrhosis and thrombocytopenia. N Engl J Med 367: 716-724, 2012.","DOI":"10.1056\/NEJMoa1110709"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/64\/18\/64_4822-24\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T03:26:26Z","timestamp":1758338786000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/64\/18\/64_4822-24\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,15]]},"references-count":20,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.4822-24","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,15]]},"article-number":"4822-24"}}