{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T13:25:36Z","timestamp":1770470736461,"version":"3.49.0"},"reference-count":28,"publisher":"Japanese Society of Internal Medicine","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2025,9,1]]},"DOI":"10.2169\/internalmedicine.4908-24","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T18:14:40Z","timestamp":1741976080000},"page":"2626-2630","source":"Crossref","is-referenced-by-count":4,"title":["Successful Resolution of Suspected Red Yeast Rice-induced Nephropathy"],"prefix":"10.2169","volume":"64","author":[{"given":"Haruka","family":"Maruyama","sequence":"first","affiliation":[{"name":"Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken-ei","family":"Sada","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Kochi Medical School, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Machiko","family":"Oka","sequence":"additional","affiliation":[{"name":"Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuru","family":"Yanai","sequence":"additional","affiliation":[{"name":"Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, Japan"},{"name":"Department of Pathology, Sapporo Tokushukai Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumi","family":"Hidaka","sequence":"additional","affiliation":[{"name":"Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuzo","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Perazella MA, Markowitz GS. Drug-induced acute interstitial nephritis. Nat Rev Nephrol 6: 461-470, 2010.","DOI":"10.1038\/nrneph.2010.71"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Praga M, Gonz\u00e1lez E. Acute interstitial nephritis. Kidney Int 77: 956-961, 2010.","DOI":"10.1038\/ki.2010.89"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Gonz\u00e1lez E, Guti\u00e9rrez E, Galeano C, et al. Early steroid treatment improves the recovery of renal function in patients with drug-induced acute interstitial nephritis. Kidney Int 73: 940-946, 2008.","DOI":"10.1038\/sj.ki.5002776"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Min HK, Kim EO, Lee SJ, et al. Rifampin-associated tubulointersititial nephritis and Fanconi syndrome presenting as hypokalemic paralysis. BMC Nephrol 14: 13, 2013.","DOI":"10.1186\/1471-2369-14-13"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Lin J, Zhuo Y, Zhang D. Nephrolithiasis and osteomalacia associated with adefovir-induced Fanconi syndrome in a patient with hepatitis B. BMC Nephrol 18: 275, 2017.","DOI":"10.1186\/s12882-017-0693-4"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Mart\u00edn-Navarro JA, Petkov-Stoyanov V, Guti\u00e9rrez-S\u00e1nchez MJ, Pedraza-Cez\u00f3n L. Acute renal failure secondary to interstitial acute nephritis and Fanconi syndrome for metamizole and gemfibrozil. Nefrologia 36: 321-323, 2016.","DOI":"10.1016\/j.nefroe.2015.06.012"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Buysschaert M, Cosyns JP, Barreto L, Jadoul M. Pamidronate-induced tubulointerstitial nephritis with Fanconi syndrome in a patient with primary hyperparathyroidism. Nephrol Dial Transplant 18: 826-829, 2003.","DOI":"10.1093\/ndt\/gfg044"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Torimoto K, Okada Y, Arao T, Mori H, Tanaka Y. A case of zoledronate-induced tubulointerstitial nephritis with Fanconi syndrome. Endocr J 59: 1051-1056, 2012.","DOI":"10.1507\/endocrj.EJ12-0166"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Jayasurya R, Srinivas BH, Ponraj M, Haridasan S, Parameswaran S, Priyamvada PS. Karyomegalic interstitial nephropathy following ifosfamide therapy. Indian J Nephrol 26: 294-297, 2016.","DOI":"10.4103\/0971-4065.171233"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Neelakantappa K, Gallo GR, Lowenstein J. Ranitidine-associated interstitial nephritis and Fanconi syndrome. Am J Kidney Dis 22: 333-336, 1993.","DOI":"10.1016\/S0272-6386(12)70327-X"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Watanabe T, Yoshikawa H, Yamazaki S, Abe Y, Abe T. Secondary renal Fanconi syndrome caused by valproate therapy. Pediatr Nephrol 20: 814-817, 2005.","DOI":"10.1007\/s00467-005-1827-7"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Kazama I, Matsubara M, Michimata M, et al. Adult onset Fanconi syndrome: extensive tubulo-interstitial lesions and glomerulopathy in the early stage of Chinese herbs nephropathy. Clin Exp Nephrol 8: 283-287, 2004.","DOI":"10.1007\/s10157-004-0296-9"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Murata Y, Hemmi S, Akiya Y, et al. Certain red yeast rice supplements in Japan cause acute tubulointerstitial injury. Kidney Int Rep 9: 2824-2828, 2024.","DOI":"10.1016\/j.ekir.2024.06.022"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Miyazaki R, Takahashi Y, Kawamura T, Ueda H, Tsuboi N, Yokoo T. Acute kidney tubular injury after ingestion of red yeast rice supplement. Clin Kidney J 17: sfae151, 2024.","DOI":"10.1093\/ckj\/sfae151"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Kawai Y, Ozawa M, Isomura A, et al. A case of Fanconi syndrome that developed following a year of consumption of a red yeast rice supplement. CEN Case Rep 14: 95-102, 2025.","DOI":"10.1007\/s13730-024-00913-y"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Maiguma M, Kihara M, Hamaguchi M, et al. Successful treatment of acute tubulointerstitial nephritis probably due to Benikoji CholesteHelp<sup>\u00ae<\/sup>, a supplement containing red yeast rice. CEN Case Rep 14: 24-28, 2025.","DOI":"10.1007\/s13730-024-00897-9"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Oda K, Murata T, Tanaka F, et al. A case of acute kidney injury and Fanconi syndrome while taking multiple supplements, including Red Yeast Rice Cholesterol Help<sup>\u00ae<\/sup>. CEN Case Rep 14: 47-51, 2025.","DOI":"10.1007\/s13730-024-00903-0"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Takeuchi K, Kawamura S, Wada Y, et al. Renal impairment of proximal tubular injury caused by red yeast rice supplement: report of 2 cases. Case Rep Nephrol Dial 14: 128-137, 2024.","DOI":"10.1159\/000540258"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Katayama Y, Miyazaki R, Takahashi Y, Kawamura T, Tsuboi N, Yokoo T. Recurrent acute kidney injury with Fanconi syndrome related to red yeast rice supplement. CEN Case Rep 14: 178-182, 2025.","DOI":"10.1007\/s13730-024-00926-7"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Koshida T, Fukuhara K, Abe K, et al. Renal injuries induced by supplements containing red yeast rice. Intern Med 64: 1195-1198, 2025.","DOI":"10.2169\/internalmedicine.4094-24"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Chikasue A, Taguchi K, Iwatani R, et al. Three cases of red yeast rice-containing supplement-induced acute kidney injury and Fanconi syndrome. Am J Kidney Dis 85: 522-526, 2025.","DOI":"10.1053\/j.ajkd.2024.08.007"},{"key":"22","unstructured":"22. Klimek M, Wang S, Ogunkanmi A. Safety and efficacy of red yeast rice (<i>Monascus purpureus<\/i>) as an alternative therapy for hyperlipidemia. P T 34: 313-327, 2009."},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Wang YH, Zhang SS, Li HT, Zhi HW, Wu HY. Rhabdomyolysis-induced acute kidney injury after administration of a red yeast rice supplement: a case report. World J Clin Cases 11: 5547-5553, 2023.","DOI":"10.12998\/wjcc.v11.i23.5547"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Flajs D, Peraica M. Toxicological properties of citrinin. Arh Hig Rada Toksikol 60: 457-464, 2009.","DOI":"10.2478\/10004-1254-60-2009-1992"},{"key":"25","doi-asserted-by":"publisher","unstructured":"25. Vanhee C, Jacobs B, Canfyn M, et al. Quality control and safety assessment of online-purchased food supplements containing red yeast rice (RYR). Foods 13: 1919, 2024.","DOI":"10.3390\/foods13121919"},{"key":"26","unstructured":"26. NHK World. What is beni-koji? [Internet]. 2024 [cited 2024 Aug 11]. Available from: https:\/\/www3.nhk.or.jp\/nhkworld\/en\/news\/backstories\/3180\/"},{"key":"27","unstructured":"27. Ministry of Health, Labour and Welfare. Information for adverse events [Internet]. [cited 2024 Oct 3]. Available from: https:\/\/www.mhlw.go.jp\/stf\/seisakunitsuite\/bunya\/kenkou_iryou\/shokuhin\/daietto\/index_00005.html"},{"key":"28","unstructured":"28. NHK WORLD. Japan health ministry: puberulic acid almost certainly caused health problems [Internet]. [cited 2024 Oct 3]. Available from: https:\/\/www3.nhk.or.jp\/nhkworld\/en\/news\/20240918_21\/"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/64\/17\/64_4908-24\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T03:25:36Z","timestamp":1757129136000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/64\/17\/64_4908-24\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,1]]},"references-count":28,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.4908-24","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,1]]},"article-number":"4908-24"}}