{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T03:30:29Z","timestamp":1763177429710,"version":"3.45.0"},"reference-count":16,"publisher":"Japanese Society of Internal Medicine","issue":"22","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2025,11,15]]},"DOI":"10.2169\/internalmedicine.4948-24","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T18:07:18Z","timestamp":1747246038000},"page":"3287-3293","source":"Crossref","is-referenced-by-count":0,"title":["An Autopsied Case of Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids for Over Four Years"],"prefix":"10.2169","volume":"64","author":[{"given":"Yusuke","family":"Sonezaki","sequence":"first","affiliation":[{"name":"Department of Nephrology, Kokura Memorial Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Shiraishi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kokura Memorial Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izumi","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kokura Memorial Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Honda","sequence":"additional","affiliation":[{"name":"Neuropathology Center, National Hospital Organization, Omuta National Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kokura Memorial Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayano","family":"Matsuyoshi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kokura Memorial Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Inamori","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kokura Memorial Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruka","family":"Sonezaki","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kokura Memorial Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Masaki","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kokura Memorial Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoma","family":"Tatsumoto","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kokura Memorial Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Suga","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kokura Memorial Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Nakagaki","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kokura Memorial Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Hidaka","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kokura Memorial Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiko","family":"Kuwahara","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kokura Memorial Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kokura Memorial Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetoshi","family":"Kanai","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kokura Memorial Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Pittock SJ, Debruyne J, Krecke KN, et al. Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). Brain 133: 2626-2634, 2010.","DOI":"10.1093\/brain\/awq164"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Axelerad AD, Stroe AZ, Mihai C, et al. CLIPPERS, chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids: a challenge in neurological practice, clinical landmarks (review). Exp Ther Med 22: 1191, 2021.","DOI":"10.3892\/etm.2021.10625"},{"key":"3","doi-asserted-by":"publisher","unstructured":"3. Dudesek A, Rimmele F, Tesar S, et al. CLIPPERS: chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. Review of an increasingly recognized entity within the spectrum of inflammatory central nervous system disorders. Clin Exp Immunol 175: 385-396, 2014.","DOI":"10.1111\/cei.12204"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Al-Chalabi M, DelCimmuto NR, Beran A, et al. Clinical characteristics, management, and outcomes of CLIPPERS: a comprehensive systematic review of 140 patients from 100 studies. Mult Scler Relat Disord 68: 104112, 2022.","DOI":"10.1016\/j.msard.2022.104112"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Cao L, Liu M, Guo L, Li M, Xu M, Wang R. The pathogenesis hypothesis and research progress of CLIPPERS: a literature review. Medicine (Baltimore) 102: e33211, 2023.","DOI":"10.1097\/MD.0000000000033211"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Moreira I, Cruto C, Correia C, Alves JE, Taipa R, Pires MM. Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS): postmortem findings. J Neuropathol Exp Neurol 74: 186-190, 2015.","DOI":"10.1097\/NEN.0000000000000162"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Taieb G, Mulero P, Psimaras D, et al.; in cooperation with the French CLIPPERS group. CLIPPERS and its mimics: evaluation of new criteria for the diagnosis of CLIPPERS. J Neurol Neurosurg Psychiatry 90: 1027-1038, 2019.","DOI":"10.1136\/jnnp-2018-318957"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Blaabjerg M, Ruprecht K, Sinnecker T, et al. Widespread inflammation in CLIPPERS syndrome indicated by autopsy and ultra-high-field 7T MRI. Neurol Neuroimmunol Neuroinflamm 3: e226, 2016.","DOI":"10.1212\/NXI.0000000000000226"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. De Graaff HJ, Wattjes MP, Rozemuller-Kwakkel AJ, Petzold A, Killestein J. Fatal B-cell lymphoma following chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. JAMA Neurol 70: 915-918, 2013.","DOI":"10.1001\/jamaneurol.2013.2016"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Lebrun L, Absil L, Remmelink M, et al. SARS-Cov-2 infection and neuropathological findings: a report of 18 cases and review of the literature. Acta Neuropathol Commun 11: 78, 2023.","DOI":"10.1186\/s40478-023-01566-1"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Weng CF, Chan DC, Chen YF, Liu FC, Liou HH. Chronic hepatitis B infection presenting with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS): a case report. J Med Case Rep 9: 266, 2015.","DOI":"10.1186\/s13256-015-0750-1"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Freua F, Mahler JV, de S\u00e1 Barreto Lima PLG, et al. Supratentorial lymphocytic inflammation with parenchymal perivascular enhancement responsive to steroids (SLIPPERS) - does it really exist? Brain Sci 13: 1191, 2023.","DOI":"10.3390\/brainsci13081191"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Yin HX, Zhou Y, Xu Y, et al. A case report of autoimmune glial fibrillary acidic protein astrocytopathy diagnosed after long term diagnosis of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. Front Neurol 11: 598650, 2020.","DOI":"10.3389\/fneur.2020.598650"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Ahn JW, Jeong JY, Hwang SK, Shin HY, Park JS. A case of diffuse large B cell lymphoma initially presenting as CLIPPERS: possible role of the Epstein-Barr virus. Neurol Sci 42: 1199-1202, 2021.","DOI":"10.1007\/s10072-020-04750-6"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Nagano M, Ayaki T, Koita N, et al. Recurrent Epstein-Barr virus-positive (EBV+) primary central nervous system lymphoma (pcnsl) in a patient with clinical features of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). Intern Med 58: 849-854, 2019.","DOI":"10.2169\/internalmedicine.1246-18"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Doubrovinskaia S, Sahm F, Thier MC, et al. Primary CNS lymphoma after CLIPPERS: a case series. J Neurol Neurosurg Psychiatry 92: 1348-1349, 2021.","DOI":"10.1136\/jnnp-2020-325759"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/64\/22\/64_4948-24\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T03:27:27Z","timestamp":1763177247000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/64\/22\/64_4948-24\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,15]]},"references-count":16,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.4948-24","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"type":"print","value":"0918-2918"},{"type":"electronic","value":"1349-7235"}],"subject":[],"published":{"date-parts":[[2025,11,15]]},"article-number":"4948-24"}}