{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T13:58:46Z","timestamp":1777039126939,"version":"3.51.4"},"reference-count":75,"publisher":"Japanese Society of Internal Medicine","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2011]]},"DOI":"10.2169\/internalmedicine.50.4462","type":"journal-article","created":{"date-parts":[[2011,1,4]],"date-time":"2011-01-04T06:07:29Z","timestamp":1294121249000},"page":"1-10","source":"Crossref","is-referenced-by-count":28,"title":["Risk Factors and Prediction of Long-term Outcome in Primary Biliary Cirrhosis"],"prefix":"10.2169","volume":"50","author":[{"given":"Hiromi","family":"Ishibashi","sequence":"first","affiliation":[{"name":"Clinical Research Center, National Hospital Organization Nagaski Medical Center, Japan"},{"name":"Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsumasa","family":"Komori","sequence":"additional","affiliation":[{"name":"Clinical Research Center, National Hospital Organization Nagaski Medical Center, Japan"},{"name":"Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Shimoda","sequence":"additional","affiliation":[{"name":"Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko M.","family":"Ambrosini","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Eric","family":"Gershwin","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Clinical Research Center, National Hospital Organization Nagaski Medical Center, Japan"},{"name":"Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jaut.2010.06.004","volume":"35","author":"Bernuzzi F, Fenoglio D, Battaglia F","year":"2010","journal-title":"J Autoimmun","ISSN":"https:\/\/id.crossref.org\/issn\/0896-8411","issn-type":"print"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Springer J, Cauch-Dudek K, O'Rourke K, Wanless IR, Heathcote EJ. Asymptomatic primary biliary cirrhosis: a study of its natural history and prognosis. Am J Gastroenterol 94: 47-53, 1999.","DOI":"10.1111\/j.1572-0241.1999.00770.x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.36027"},{"key":"4","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1053\/j.gastro.2009.01.003","volume":"136","author":"Kuiper EM, Hansen BE, de Vries RA,","year":"2009","journal-title":"Gastroenterology","ISSN":"https:\/\/id.crossref.org\/issn\/0016-5085","issn-type":"print"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.11.016"},{"key":"6","doi-asserted-by":"crossref","first-page":"A259","DOI":"10.1016\/j.autrev.2009.12.002","volume":"9","author":"Lleo A, Invernizzi P, Gao B, Podda","year":"2010","journal-title":"Autoimmun Rev","ISSN":"https:\/\/id.crossref.org\/issn\/1568-9972","issn-type":"print"},{"key":"7","first-page":"47","volume":"10","author":"Gershwin ME, Rowley M, Davis PA, Le","year":"1992","journal-title":"Prog Liver Dis","ISSN":"https:\/\/id.crossref.org\/issn\/1060-913X","issn-type":"print"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510270303"},{"key":"9","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1002\/hep.1840060609","volume":"6","author":"Mitchison HC, Bassendine MF, Hendri","year":"1986","journal-title":"Hepatology","ISSN":"https:\/\/id.crossref.org\/issn\/0270-9139","issn-type":"print"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)04410-8"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(05)80139-4"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2009.02405.x"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.1996.v23.pm0008550048"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.09.031"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.33157"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.1997.v26.pm0009362353"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290511"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290301"},{"key":"19","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1053\/jhep.2000.20240","volume":"32","author":"Corpechot C, Carrat F, Bonnand AM,","year":"2000","journal-title":"Hepatology","ISSN":"https:\/\/id.crossref.org\/issn\/0270-9139","issn-type":"print"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6346(01)00148-6"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(03)00192-2"},{"key":"22","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1055\/s-2005-916323","volume":"25","author":"Lee YM, Kaplan MM","year":"2005","journal-title":"Semin Liver Dis","ISSN":"https:\/\/id.crossref.org\/issn\/0272-8087","issn-type":"print"},{"key":"23","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1053\/j.gastro.2004.11.009","volume":"128","author":"Corpechot C, Carrat F, Bahr A, Chre","year":"2005","journal-title":"Gastroenterology","ISSN":"https:\/\/id.crossref.org\/issn\/0016-5085","issn-type":"print"},{"key":"24","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1053\/j.gastro.2005.12.029","volume":"130","author":"Pares A, Caballeria L, Rodes J","year":"2006","journal-title":"Gastroenterology","ISSN":"https:\/\/id.crossref.org\/issn\/0016-5085","issn-type":"print"},{"key":"25","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/hep.22428","volume":"48","author":"Corpechot C, Abenavoli L, Rabahi N,","year":"2008","journal-title":"Hepatology","ISSN":"https:\/\/id.crossref.org\/issn\/0270-9139","issn-type":"print"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Kumagi T, Guindi M, Fischer SE, et al. Baseline ductopenia and treatment response predict long-term histological progression in primary biliary cirrhosis. Am J Gastroenterol 105: 2186-2194, 2010.","DOI":"10.1038\/ajg.2010.216"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Tanaka A, Borchers AT, Ishibashi H, Ansari AA, Keen CL, Gershwin ME. Genetic and familial considerations of primary biliary cirrhosis. Am J Gastroenterol 96: 8-15, 2001.","DOI":"10.1111\/j.1572-0241.2001.03446.x"},{"key":"28","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1053\/j.gastro.2004.05.005","volume":"127","author":"Selmi C, Mayo MJ, Bach N, et al","year":"2004","journal-title":"Gastroenterology","ISSN":"https:\/\/id.crossref.org\/issn\/0016-5085","issn-type":"print"},{"key":"29","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.jhep.2008.07.027","volume":"49","author":"Poupon R, Ping C, Chretien Y, et al","year":"2008","journal-title":"J Hepatol","ISSN":"https:\/\/id.crossref.org\/issn\/0168-8278","issn-type":"print"},{"key":"30","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1056\/NEJMoa0810440","volume":"360","author":"Hirschfield GM, Liu X, Xu C, et al","year":"2009","journal-title":"N Engl J Med","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1038\/ng.631"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1038\/ng.627"},{"key":"33","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1002\/hep.20907","volume":"42","author":"Gershwin ME, Selmi C, Worman HJ, et","year":"2005","journal-title":"Hepatology","ISSN":"https:\/\/id.crossref.org\/issn\/0270-9139","issn-type":"print"},{"key":"34","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/hep.21076","volume":"43","author":"Ala A, Stanca CM, Bu-Ghanim M, et a","year":"2006","journal-title":"Hepatology","ISSN":"https:\/\/id.crossref.org\/issn\/0270-9139","issn-type":"print"},{"key":"35","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1002\/hep.21423","volume":"44","author":"Zein CO, Beatty K, Post AB, Logan L","year":"2006","journal-title":"Hepatology","ISSN":"https:\/\/id.crossref.org\/issn\/0270-9139","issn-type":"print"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Leung PS, Park O, Tsuneyama K, et al. Induction of primary biliary cirrhosis in guinea pigs following chemical xenobiotic immunization. J Immunol 179: 2651-2657, 2007.","DOI":"10.4049\/jimmunol.179.4.2651"},{"key":"37","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1002\/hep.23139","volume":"50","author":"McNally RJ, Ducker S, James OF","year":"2009","journal-title":"Hepatology","ISSN":"https:\/\/id.crossref.org\/issn\/0270-9139","issn-type":"print"},{"key":"38","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.cld.2008.02.009","volume":"12","author":"Muratori L, Granito A, Muratori P,","year":"2008","journal-title":"Clin Liver Dis","ISSN":"https:\/\/id.crossref.org\/issn\/1089-3261","issn-type":"print"},{"key":"39","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/S1542-3565(04)00465-3","volume":"2","author":"Yang WH, Yu JH, Nakajima A, Neuberg","year":"2004","journal-title":"Clin Gastroenterol Hepatol","ISSN":"https:\/\/id.crossref.org\/issn\/1542-3565","issn-type":"print"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1995.tb01597.x"},{"key":"41","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.autrev.2010.05.013","volume":"9","author":"Tzioufas AG, Routsias JG","year":"2010","journal-title":"Autoimmun Rev","ISSN":"https:\/\/id.crossref.org\/issn\/1568-9972","issn-type":"print"},{"key":"42","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.autrev.2010.05.006","volume":"9","author":"Varin MM, Le Pottier L, Youinou P,","year":"2010","journal-title":"Autoimmun Rev","ISSN":"https:\/\/id.crossref.org\/issn\/1568-9972","issn-type":"print"},{"key":"43","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.autrev.2009.02.002","volume":"8","author":"Cavazzana I, Angela C, Paolo A, Ste","year":"2009","journal-title":"Autoimmun Rev","ISSN":"https:\/\/id.crossref.org\/issn\/1568-9972","issn-type":"print"},{"key":"44","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1440-1746.1998.01553.x","volume":"13","author":"Itoh S, Ichida T, Yoshida T, et al","year":"1998","journal-title":"J Gastroenterol Hepatol","ISSN":"https:\/\/id.crossref.org\/issn\/0815-9319","issn-type":"print"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)00040-4"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Muratori P, Muratori L, Ferrari R, et al. Characterization and clinical impact of antinuclear antibodies in primary biliary cirrhosis. Am J Gastroenterol 98: 431-437, 2003.","DOI":"10.1111\/j.1572-0241.2003.07257.x"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-8411(03)00033-7"},{"key":"48","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1002\/hep.21172","volume":"43","author":"Wesierska-Gadek J, Penner E, Battez","year":"2006","journal-title":"Hepatology","ISSN":"https:\/\/id.crossref.org\/issn\/0270-9139","issn-type":"print"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21472"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2010.00631.x"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1268-4"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80098-1"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290444"},{"key":"54","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/hep.20650","volume":"41","author":"Clouston AD, Powell EE, Walsh MJ, R","year":"2005","journal-title":"Hepatology","ISSN":"https:\/\/id.crossref.org\/issn\/0270-9139","issn-type":"print"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.08.006"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2006.tb00292.x"},{"issue":"Supplement 3","key":"57","doi-asserted-by":"crossref","first-page":"S412","DOI":"10.1111\/j.1872-034X.2007.00244.x","volume":"37","author":"NAKAMURA MINORU","year":"2007","journal-title":"Hepatol Res","ISSN":"https:\/\/id.crossref.org\/issn\/1386-6346","issn-type":"print"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116504"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59. Guldner HH, Szostecki C, Grotzinger T, Will H. IFN enhance expression of Sp100, an autoantigen in primary biliary cirrhosis. J Immunol 149: 4067-4073, 1992.","DOI":"10.4049\/jimmunol.149.12.4067"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2005.10.007"},{"key":"61","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1034\/j.1600-065X.2003.00042.x","volume":"193","author":"Ferguson TA, Stuart PM, Hemdon JM,","year":"2003","journal-title":"Immunol Rev","ISSN":"https:\/\/id.crossref.org\/issn\/0105-2896","issn-type":"print"},{"key":"62","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jaut.2008.04.009","volume":"31","author":"Lleo A, Selmi C, Invernizzi P, Podd","year":"2008","journal-title":"J Autoimmun","ISSN":"https:\/\/id.crossref.org\/issn\/0896-8411","issn-type":"print"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.1997.v26.pm0009397977"},{"key":"64","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.autrev.2004.08.038","volume":"4","author":"Chen M, von Mikecz A","year":"2005","journal-title":"Autoimmun Rev","ISSN":"https:\/\/id.crossref.org\/issn\/1568-9972","issn-type":"print"},{"key":"65","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/hep.22736","volume":"49","author":"Lleo A, Selmi C, Invernizzi P, et a","year":"2009","journal-title":"Hepatology","ISSN":"https:\/\/id.crossref.org\/issn\/0270-9139","issn-type":"print"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.5.1835"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2000.18714"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00387-1"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021933"},{"key":"70","doi-asserted-by":"crossref","unstructured":"70. Amre DK, Lu SE, Costea F, Seidman EG. Utility of serological markers in predicting the early occurrence of complications and surgery in pediatric Crohn's disease patients. Am J Gastroenterol 101: 645-652, 2006.","DOI":"10.1111\/j.1572-0241.2006.00468.x"},{"key":"71","doi-asserted-by":"crossref","unstructured":"71. Takeshita E, Kumagi T, Matsui H, et al. Esophagogastric varices as a prognostic factor for the determination of clinical stage in patients with primary biliary cirrhosis. J Gastroenterol 38: 1060-1065, 2003.","DOI":"10.1007\/s00535-003-1196-6"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1016\/j.hepres.2006.07.008"},{"key":"73","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.jhep.2009.11.027","volume":"52","author":"Poupon R","year":"2010","journal-title":"J Hepatol","ISSN":"https:\/\/id.crossref.org\/issn\/0168-8278","issn-type":"print"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.08.009"},{"issue":"1 Pt 1","key":"75","first-page":"126","volume":"20","year":"1994","journal-title":"Hepatology","ISSN":"https:\/\/id.crossref.org\/issn\/0270-9139","issn-type":"print"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/50\/1\/50_1_1\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T18:37:38Z","timestamp":1685903858000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/50\/1\/50_1_1\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":75,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.50.4462","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}