{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T04:17:09Z","timestamp":1783138629986,"version":"3.54.6"},"reference-count":22,"publisher":"Japanese Society of Internal Medicine","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2026,7,1]]},"DOI":"10.2169\/internalmedicine.5151-24","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T22:07:33Z","timestamp":1764194853000},"page":"1730-1736","source":"Crossref","is-referenced-by-count":2,"title":["Differences in Coronary Microvascular Spasms Induced by Acetylcholine and Ergonovine"],"prefix":"10.2169","volume":"65","author":[{"given":"Shozo","family":"Sueda","sequence":"first","affiliation":[{"name":"Department of Cardiology, Ehime Niihama Prefectural Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ehime Niihama Prefectural Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikaru","family":"Okabe","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ehime Niihama Prefectural Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsukasa","family":"Kurokawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ehime Niihama Prefectural Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ehime Niihama Prefectural Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Habara","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ehime Niihama Prefectural Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Minami Matsuyama Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ehime University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Sakaue","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ehime University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuntaro","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ehime University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Sueda S, Kohno H, Fukuda H, et al. Clinical impact of selective spasm provocation tests: comparisons between acetylcholine and ergonovine in 1508 examinations. Coron Artery Dis 15: 491-497, 2004.","DOI":"10.1097\/00019501-200412000-00006"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Sueda S, Fujimoto K, Sasaki Y, et al. Differential incidence and morphology of provoked spasm between intracoronary acetylcholine and ergonovine testing: recommendation of supplementary use. Heart Vessels 34: 745-754, 2019.","DOI":"10.1007\/s00380-018-1299-x"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Sueda S, Kohno H, Fukuda H, et al. Induction of coronary artery spasm by two pharmacological agents: comparison between intracoronary injection of acetylcholine and ergonovine. Coron Artery Dis 14: 451-457, 2003.","DOI":"10.1097\/00019501-200309000-00006"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Horimoto M, Igashira K, Takenaka T, Inoue H, Yamazaki K, Sakuragi H. Acetylcholine- and ergonovine-induced coronary microvascular spasm reflected by increased coronary vascular resistance and myocardial lactate production. Clin Cardiol 23: 221-225, 2000.","DOI":"10.1002\/clc.4960230320"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Serota H, Kern MJ, Deligonul U, Aguirre F, Caralis DG. Ergonoine-induced myocardial ischemia without epicardial coronary vasospasm: evidence for ischemia produced by small-vessel vasoconstriction. Am Heart J 121: 1807-1809, 1991.","DOI":"10.1016\/0002-8703(91)90031-C"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Yamagishi H, Itagane H, Hato K, et al. A case of rest angina due to microvascular spasm. Jpn Circ J 61: 87-89, 1997.","DOI":"10.1253\/jcj.61.87"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Tomita M, Matsubara H, Kanai T, et al. Angina pectoris induced by microcoronary artery spasm. Showa Univ J Med Sci 11: 281-286, 1999.","DOI":"10.15369\/sujms1989.11.281"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Kawakami K, Shimada T, Nakayama K, et al. Angina pectoris due to possible vasospasm of small coronary arteries. Clin Cardiol 14: 775-777, 1991.","DOI":"10.1002\/clc.4960140914"},{"key":"9","doi-asserted-by":"publisher","unstructured":"9. Mohri M, Koyanagi M, Egashira K, et al. Angina pectoris cause by coronary microvascular spasm. Lancet 351: 1165-1169, 1998.","DOI":"10.1016\/S0140-6736(97)07329-7"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Murakami H, Urabe K, Nishimura M. Inappropriate microvascular constriction produced transient ST-segment elevation in patients with syndrome X. J Am Coll Cardiol 32: 1287-1294, 1998.","DOI":"10.1016\/S0735-1097(98)00402-1"},{"key":"11","doi-asserted-by":"publisher","unstructured":"11. Yasue H, Horio Y, Nakamura N, et al. Induction of coronary artery spasm by acetylcholine in patients with variant angina: possible role of the parasympathetic nervous system in the pathogenesis of coronary artery spasm. Circulation 74: 955-963, 1986.","DOI":"10.1161\/01.CIR.74.5.955"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Yokoyama M, Akita H, Mizutani T, Fukuzaki H, Watanabe Y. Hyperreactivity of coronary arterial smooth muscles in response to ergonovine from rabbits with hereditary hyperlipidemia. Circ Res 53: 63-71, 1983.","DOI":"10.1161\/01.RES.53.1.63"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Kanazawa K, Suematsu M, Ishida T, et al. Disparity between serotonin- and acetylcholine-provoked coronary artery spasm. Clin Cardiol 20: 146-152, 1997.","DOI":"10.1002\/clc.4960200212"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Sueda S, Sakaue T. Intracoronary acetylcholine testing among 746 consecutive Japanese patients with angina-like chest pain and unobstructed coronary artery disease. Eur Heart J Open 2: 1-10, 2021.","DOI":"10.1093\/ehjopen\/oeab012"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Sueda S, Sakaue T. A review of the role of tests of coronary reactivity in clinical practice. Eur Cardiol Rev 19: e16, 2024.","DOI":"10.15420\/ecr.2022.12"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Sueda S, Hayashi Y, Ono H, Sakaue T, Ikeda S. Safety and usefulness of intracoronary acetylcholine 200 mg into the left coronary artery as vasoreactivity testing: comparisons with intracoronary acetylcholine maximum 100 mg. Clin Cardiol 47: e70001, 2024.","DOI":"10.1002\/clc.70001"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Hokimoto S, Kaikita K, Yasuda S, et al.; Japanese Circulation Society and Japanese Association of Cardiovascular Intervention and Therapeutics and Japanese College of Cardiology Joint Working Group. JCS\/CVIT\/JCC 2023 Guideline focus update on diagnosis and treatment of vasospastic angina (coronary spastic angina) and coronary microvascular dysfunction. Cir J 87: 879-936, 2023.","DOI":"10.1253\/circj.CJ-22-0779"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Ong P, Camici PG, Beltrame J, et al.; Coronary Vamotion Disorders International Study Group (COVADIS). International standardization of diagnostic criteria for microvascular angina. Int J Cardiol 250: 16-20, 2018.","DOI":"10.1016\/j.ijcard.2017.08.068"},{"key":"19","unstructured":"19. Scanlon PJ, Faxon DP, Audet AM, et al. ACC\/AHA guidelines for coronary angiography. A report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (Committee on Coronary Angiography). J Am Coll Cardiol 33: 1756-1824, 1999."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Sueda S, Kohno H, Ochi T, Uraoka T, Tsunemitsu K. Overview of the pharmacological spasm provocation test: comparisons between acetylcholine and ergonovine. J Cardiol 69: 57-65, 2017.","DOI":"10.1016\/j.jjcc.2016.09.012"},{"key":"21","unstructured":"21. Knuuti J, Wijns W, Saraste A, et al.; ESC Scientific Document Group. 2019 ESC guidelines for the diagnosis and management of chronic coronary syndromes. Eur Heart J 41: 407-477, 2020."},{"key":"22","unstructured":"22. Anderson JL, Adams CD, Antman EM, et al. 2012 ACCF\/AHA focused update incorporated into the ACCF\/AHA 2007 guidelines for the management of patients with unstable angina\/non-ST-elevation myocardial infarctions: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines. Circulation 127: 3663-3828, 2013."}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/65\/13\/65_5151-24\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T03:29:51Z","timestamp":1783135791000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/65\/13\/65_5151-24\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":22,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.5151-24","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]},"article-number":"5151-24"}}