{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T04:41:35Z","timestamp":1760762495377,"version":"build-2065373602"},"reference-count":39,"publisher":"Japanese Society of Internal Medicine","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2025,10,15]]},"DOI":"10.2169\/internalmedicine.5159-24","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T18:09:48Z","timestamp":1744394988000},"page":"3012-3019","source":"Crossref","is-referenced-by-count":0,"title":["Salvage HLA-haploidentical Peripheral Blood Stem Cell Transplantation Using Post-transplant Cyclophosphamide for Recurrent Hemophagocytic Lymphohistiocytosis-associated Graft Failure after Cord Blood Transplantations"],"prefix":"10.2169","volume":"64","author":[{"given":"Keijiro","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Hematology, Nagano Red Cross Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Komaba","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nagano Red Cross Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saika","family":"Oka","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nagano Red Cross Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Kazama","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nagano Red Cross Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuto","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nagano Red Cross Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Morikawa","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nagano Red Cross Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Kitahara","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nagano Red Cross Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Kazumoto","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nagano Red Cross Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Kaiume","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nagano Red Cross Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshimitsu","family":"Ueki","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nagano Red Cross Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Hiroshima","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nagano Red Cross Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Sumi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nagano Red Cross Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hikaru","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nagano Red Cross Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Takami A. Treatment of graft failure after allogeneic hematopoietic stem cell transplantation: current status. Nihon Zoketsu Saibo Ishoku Gakkai Zasshi (J Hematopoietic Cell Transplant) 2: 61-69, 2013 (in Japanese).","DOI":"10.7889\/hct.2.61"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Chakrabarty JH, Glover J, Schmidt S, et al. Incidence and risk factors for graft failure in the modern era of cord blood transplantation. Vox Sang 117: 1405-1410, 2022.","DOI":"10.1111\/vox.13368"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Yamamoto H. Single cord blood transplantation in Japan; expanding the possibilities of CBT. Int J Hematol 110: 39-49, 2019.","DOI":"10.1007\/s12185-019-02672-4"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Harada K, Najima Y, Kato M, et al. Outcomes of salvage haploidentical transplantation using posttransplant cyclophosphamide for graft failure following allogeneic hematopoietic stem cell transplantation. Int J Hematol 116: 744-753, 2022.","DOI":"10.1007\/s12185-022-03405-w"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Harada K, Fuji S, Seo S, et al. Comparison of the outcomes after haploidentical and cord blood salvage transplantations for graft failure following allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 55: 1784-1795, 2020.","DOI":"10.1038\/s41409-020-0821-9"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Prata PH, Resche-Rigon M, Blaise D, et al. Outcomes of salvage haploidentical transplant with post-transplant cyclophosphamide for rescuing graft failure patients: a report on behalf of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy. Biol Blood Marrow Transplant 25: 1798-1802, 2019.","DOI":"10.1016\/j.bbmt.2019.05.013"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Kongtim P, Bittencourt M, Srour SA, et al. Haploidentical transplants for patients with graft failure after the first allograft. Am J Hematol 95: E267-E269, 2020.","DOI":"10.1002\/ajh.25917"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Albert MH, Sirin M, Hoenig M, et al. Salvage HLA-haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide for graft failure in non-malignant disorders. Bone Marrow Transplant 56: 2248-2258, 2021.","DOI":"10.1038\/s41409-021-01323-9"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Pagliuca S, Legendre H, Morin S, et al. Success of haploidentical hematopoietic stem cells transplantation in the treatment of graft failure. Ann Hematol 95: 353-354, 2016.","DOI":"10.1007\/s00277-015-2525-6"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Kliman D, Bilmon I, Kwan J, et al. Rescue haploidentical peripheral blood stem cell transplantation for engraftment failure: a single-centre case series. Intern Med J 48: 988-991, 2018.","DOI":"10.1111\/imj.13979"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Takagi S, Masuoka K, Uchida N, et al. High incidence of haemophagocytic syndrome following umbilical cord blood transplantation for adults. Br J Haematol 147: 543-553, 2009.","DOI":"10.1111\/j.1365-2141.2009.07863.x"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Ota H, Masuoka K, Uchida N, et al. Possible two different mechanisms of engraftment failure in cord blood transplantation: graft rejection and poor graft function. Blood 118: 651, 2011.","DOI":"10.1182\/blood.V118.21.651.651"},{"key":"13","unstructured":"13. Yamamoto H. Cord blood transplantation: current status and new perspectives. Rinsho Ketsueki (Jpn J Clin Hematol) 57: 278-287, 2016 (In Japanese)."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Inoue M. Pathophysiology and treatment for hemophagocytic lymphohistiocytosis after hematopoietic cell transplantation. Nihon Zoketsu Saibo Ishoku Gakkai Zasshi (J Hematopoietic Cell Transplant) 5: 118-123, 2016 (in Japanese).","DOI":"10.7889\/hct.5.118"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Sumi M, Shimizu I, Sato K, et al. Graft failure in cord blood transplantation successfully treated with short-term reduced-intensity conditioning regimen and second allogeneic transplantation. Int J Hematol 92: 744-750, 2010.","DOI":"10.1007\/s12185-010-0714-6"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Matsuno N, Yamamoto H, Watanabe N, et al. Rapid T-cell chimerism switch and memory T-cell expansion are associated with pre-engraftment immune reaction early after cord blood transplantation. Br J Haematol 160: 255-258, 2013.","DOI":"10.1111\/bjh.12097"},{"key":"17","doi-asserted-by":"publisher","unstructured":"17. Uchida N, Wake A, Nakano N, et al. Mycophenolate and tacrolimus for graft-versus-host disease prophylaxis for elderly after cord blood transplantation: a matched pair comparison with tacrolimus alone. Transplantation 92: 366-371, 2011.","DOI":"10.1097\/TP.0b013e318223d7ac"},{"key":"18","unstructured":"18. Sato K, Sumi M, Maruyama M, et al. Perforated upper gastrointestinal ulcers potentially attributable to mycophenolate mofetil after allogeneic hematopoietic stem cell transplantation. Rinsho Ketsueki (Jpn J Clin Hematol) 63: 1402-1408, 2022 (in Japanese)."},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Yuda S, Fuji S, Savani B, Gatwood KS. Antiemetic strategies in patients who undergo hematopoietic stem cell transplantation. Clin Hematol Int 4: 89-98, 2022.","DOI":"10.1007\/s44228-022-00012-8"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Uchida N, Yamamoto H, Taniguchi S. Umbilical cord blood transplantation in adults: an update and future prospects. Nihon Zoketsu Saibo Ishoku Gakkai Zasshi (J Hematopoietic Cell Transplant) 2: 1-11, 2013.","DOI":"10.7889\/hct.2.1"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Merli P, Caruana I, De Vito R, et al. Role of interferon-\u03b3 in immune-mediated graft failure after allogeneic hematopoietic stem cell transplantation. Haematologica 104: 2314-2323, 2019.","DOI":"10.3324\/haematol.2019.216101"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Tian Z, Man Q, Yang Y, et al. Successful treatment of severe steroid-resistant engraftment syndrome following haploidentical allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia with emapalumab: a case report. Cancer Manag Res 16: 585-591, 2024.","DOI":"10.2147\/CMAR.S458577"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Hattori N, Sato M, Uesugi Y, et al. Characteristics and predictors of post-transplant-associated hemophagocytic lymphohistiocytosis in adults. Int J Hematol 113: 693-702, 2021.","DOI":"10.1007\/s12185-020-03067-6"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Alblooshi RM, Deotare U, Michelis FV, et al. My jamais vu in post allogeneic hematopoietic cell transplant: a review on secondary hemophagocytosis in adults. Bone Marrow Transplant 55: 867-872, 2020.","DOI":"10.1038\/s41409-019-0711-1"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Jaiswal SR, Chakrabarti A, Chatterjee S, Bhargava S, Ray K, Chakrabarti S. Hemophagocytic syndrome following haploidentical peripheral blood stem cell transplantation with post-transplant cyclophosphamide. Int J Hematol 103: 234-242, 2016.","DOI":"10.1007\/s12185-015-1905-y"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Sandler RD, Carter S, Kaur H, Francis S, Tattersall RS, Snowden JA. Haemophagocytic lymphohistiocytosis (HLH) following allogeneic haematopoietic stem cell transplantation (HSCT)-time to reappraise with modern diagnostic and treatment strategies? Bone Marrow Transplant 55: 307-316, 2020.","DOI":"10.1038\/s41409-019-0637-7"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Fuji S, Nakamura F, Hatanaka K, et al. Peripheral blood as a preferable source of stem cells for salvage transplantation in patients with graft failure after cord blood transplantation: a retrospective analysis of the registry data of the Japanese Society for Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant 18: 1407-1414, 2012.","DOI":"10.1016\/j.bbmt.2012.02.014"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Waki F, Masuoka K, Fukuda T, et al. Feasibility of reduced-intensity cord blood transplantation as salvage therapy for graft failure: results of a nationwide survey of adult patients. Biol Blood Marrow Transplant 17: 841-851, 2011.","DOI":"10.1016\/j.bbmt.2010.09.005"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Fuji S. Haploidentical related peripheral blood stem cell transplantation as a salvage transplantation in patients with graft failure. Intern Med 54: 2709-2710, 2015.","DOI":"10.2169\/internalmedicine.54.5323"},{"key":"30","unstructured":"30. Kaiume H, Sumi M, Kirihara T, et al. Primary graft failure in a patient with refractory acute myeloid leukemia successfully treated with modified 'one-day' -based preparative regimen followed by cord blood transplantation. Rinsho Ketsueki (Jpn J Clin Hematol) 56: 711-715, 2015 (in Japanese)."},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Bolwell B, Sobecks R, Pohlman B, et al. A prospective randomized trial comparing cyclosporine and short course methotrexate with cyclosporine and mycophenolate mofetil for GVHD prophylaxis in myeloablative allogeneic bone marrow transplantation. Bone Marrow Transplant 34: 621-625, 2004.","DOI":"10.1038\/sj.bmt.1704647"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Sugio T, Kato K, Yoshida S, et al. Short-term methotrexate plus cyclosporine for graft-versus-host disease prophylaxis after single-unit cord blood transplantation following reduced-intensity conditioning. Nihon Zoketsu, Men'eki Saibo Ryoho Gakkai Zasshi (Jpn J Transplant Cell Ther) 11: 64-71, 2022.","DOI":"10.7889\/tct-21-001"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. O'Donnell PV, Luznik L, Jones RJ, et al. Nonmyeloablative bone marrow transplantation from partially HLA-mismatched related donors using posttransplantation cyclophosphamide. Biol Blood Marrow Transplant 8: 377-386, 2002.","DOI":"10.1053\/bbmt.2002.v8.pm12171484"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Sugita J. Cytokine release syndrome after HLA-haploidentical stem cell transplantation with posttransplant cyclophosphamide. Nihon Zoketsu Saibo Ishoku Gakkai Zasshi (J Hematopoietic Cell Transplant) 10: 66-71, 2021 (In Japanese).","DOI":"10.7889\/hct-20-016"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Copland M. Treatment of blast phase chronic myeloid leukaemia: A rare and challenging entity. Br J Haematol 199: 665-678, 2022.","DOI":"10.1111\/bjh.18370"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Brioli A, Lomaia E, Fabisch C, et al. Management and outcome of patients with chronic myeloid leukemia in blast phase in the tyrosine kinase inhibitor era - analysis of the European LeukemiaNet Blast Phase Registry. Leukemia 38: 1072-1080, 2024.","DOI":"10.1038\/s41375-024-02204-y"},{"key":"37","unstructured":"37. Aoki M, Maeda T, Ishikawa M, et al. Successful treatment with sequential blinatumomab\/ponatinib in a patient with chronic myeloid leukemia presenting with a CD19-positive mixed phenotype blast phase. Rinsho Ketsueki (Jpn J Clin Hematol) 65: 1375-1380, 2024 (in Japanese)."},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Choi W, Kim M, Lim J, et al. Four cases of chronic myelogenous leukemia in mixed phenotype blast phase at initial presentation mimicking mixed phenotype acute leukemia with t (9;22). Ann Lab Med 34: 60-63, 2014.","DOI":"10.3343\/alm.2014.34.1.60"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Gong Z, Bai S, Hu S. Mixed phenotype blast phase of chronic myeloid leukemia in the era of tyrosine kinase inhibitor therapy. Blood 128: 5438, 2016.","DOI":"10.1182\/blood.V128.22.5438.5438"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/64\/20\/64_5159-24\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T04:27:37Z","timestamp":1760761657000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/64\/20\/64_5159-24\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,15]]},"references-count":39,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.5159-24","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"type":"print","value":"0918-2918"},{"type":"electronic","value":"1349-7235"}],"subject":[],"published":{"date-parts":[[2025,10,15]]},"article-number":"5159-24"}}