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Sugimoto M, Mita S, Tokunaga M, et al. Pulmonary involvement in human T-cell lymphotropic virus type-I uvetitis: T-lymphocytosis and high proviral DNA load in bronchoalveolar lavage fluid. Eur Respir J 6: 938-943, 1993."},{"key":"2","unstructured":"2. Sugimoto M, Nakashima H, Matsumoto M, Uyama E, Ando M, Araki S. Pulmonary involvement in patients with HTLV-1 associated myelopathy: increased soluble IL-2 receptors in bronchoalveolar lavage fluid. Am Rev Respir Dis 139: 1329-1335, 1989."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Seki M, Kadota JI, Higashiyama Y, et al. Elevated levels of &beta;-chemokines in bronchoalveolar lavage fluid of individuals infected with human T lymphotropic virus type-1. Clin Exp Immunol 118: 417-422, 1999.","DOI":"10.1046\/j.1365-2249.1999.01093.x"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Yamazato Y, Miyazato Y, Kawakami K, Yara S, Kaneshima H, Saito A. High expression of p40<sup>tax<\/sup> and pro-inflammatory cytokines and chemokines in the lungs of human T-lymphotropic virus type-1-related bronchopulmonary disorders. Chest 124: 2283-2292, 2003.","DOI":"10.1378\/chest.124.6.2283"},{"key":"5","unstructured":"5. Araki J, Kaku M, Mashimoto H, Fukuda Y, Asai S. A case of HTLV-1 associated myelopathy with pulmonary involvement. Nihon Kyobu Shikkan Gakkai Zasshi 27: 1375-1379, 1989 (in Japanese, Abstract in English)."},{"key":"6","unstructured":"6. Hayasaka S, Sugimoto M, Kiyama T, Yoshinaga K, Fujino N, Kinuwaki E. Bronchoalveolar lavage studies in a HTLV-1-positive case associated with interstitial pneumonia. Nihon Kyobu Shikkan Gakkai Zasshi 29: 740-745, 1991 (in Japanese, Abstract in English)."},{"key":"7","unstructured":"7. Kimura I. HABA (HTLV-1 associated bronchiolo-alveolar disorder). Nihon Kyobu Shikkan Gakkai Zasshi 30: 787-795, 1992 (in Japanese, Abstract in English)."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Matsuse T, Fukuchi Y, Hsu CY, et al. Detection of human T lymphotropic virus type 1 proviral DNA in patients with diffuse panbronchiolitis. Respirology 1: 139-144, 1996.","DOI":"10.1111\/j.1440-1843.1996.tb00023.x"},{"key":"9","unstructured":"9. Shinkai M, Kobayashi H, Saito W, et al. A case of HTLV-1-associated bronchiolitis with Sj&ouml;gren's syndrome. Nihon Kokyuki Gakkai Zasshi 41: 228-232, 2003."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Yu H, Fujita J, Higa F, et al. Nonspecific interstitial pneumonia pattern as pulmonary involvement in human T-cell lymphotropic virus type 1 carriers. J Infect Chemother 15: 284-287, 2009.","DOI":"10.1007\/s10156-009-0707-7"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Katzenstein AL, Fiorelli RF. Nonspecific interstitial pneumonia\/fibrosis. Histologic features and clinical significance. Am J Surg Pathol 18: 136-147, 1994.","DOI":"10.1097\/00000478-199402000-00003"},{"key":"12","unstructured":"12. Kim EY, Lee KS, Chung MP, Kwon OJ, Kim TS, Hwang JH. Nonspecific interstitial pneumonia with fibrosis: serial high-resolution CT findings with functional correlation. Am J Roentgenol 173: 949-953, 1999."},{"key":"13","unstructured":"13. Hartman TE, Swensen SJ, Hansell DM, et al. Nonspecific interstitial pneumonia: variable appearance at high-resolution chest CT. Radiology 217: 701-705, 2000."},{"key":"14","unstructured":"14. Seiki M, Hattori S, Hirayama Y, Yoshida M. Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA. Proc Natl Acad Sci USA 80: 3618-3622, 1983."},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Matsuoka M, Jeang KT. Human T-cell leukemina virus type-1 infectivity and cellular transformation. Nat Rev Cancer 7: 270-280, 2007.","DOI":"10.1038\/nrc2111"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Gaudray G, Gachon F, Basbous J, Biard Piechaczyk M, Devaux C, Mesnars JM. The complementary strand of the human T-cell leukemia virus type-1 RNA genome encodes a bZIP transcription factor that downregulates viral transcription. J Virol 76: 12813-12822, 2002.","DOI":"10.1128\/JVI.76.24.12813-12822.2002"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Satou Y, Yasunaga J, Yoshida M, et al. HTLV-1 basic leucine zipper factor gene mRNA supports proliferation of adult T-cell leukemia cells. Proc Natl Acad Sci USA 17: 720-725, 2006.","DOI":"10.1073\/pnas.0507631103"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Arnold J, Yamamoto B, Li M, et al. Enhancement of infectivity and persistence <i>in vivo<\/i> by HBZ, a natural antisense coded protein of HTLV-1. Blood 107: 3976-3982, 2006.","DOI":"10.1182\/blood-2005-11-4551"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Arnold J, Zimmerman B, Li M, Lairmore MD, Green PM. Human T-cell leukemia virus type-1 antisense-encoded gene, Hbz promotes T-lymphocyte proliferation. Blood 112: 3788-3797, 2008.","DOI":"10.1182\/blood-2008-04-154286"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Satou Y, Yasunaga J, Zhao T, et al. HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation <i>in vivo<\/i>. PLoS Pathogens 7: 1-14, 2011.","DOI":"10.1371\/journal.ppat.1001274"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Saito M, Matsuzaki T, Satou Y, et al. <i>In vivo<\/i> expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy\/tropical spastic paraparesis (HAM\/TSP). Retrovirology 6: 1-11, 2009.","DOI":"10.1186\/1742-4690-6-19"},{"key":"22","unstructured":"22. Andrade RG, Goncalves PC, Riveiro MA, et al. Strong correlation between tax and HBZ mRNA expression in HAM\/TSP patients: distinct markers for the neurologic disease. J Clin Virol 56: 135-140, 2012."},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Karube K, Ohshima K, Tsuchiya T, et al. Expression of FoxP3, a key molecule in CD4CD25 regulatory T-cells in adult T-cell leukemia\/lymphoma cells. Br J Haematol 126: 81-84, 2004.","DOI":"10.1111\/j.1365-2141.2004.04999.x"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Chen S, Ishii N, Ine S, et al. Regulatory T cell-like activity of Foxp3+ adult T-cell leukemia cells. Int Immunol 18: 269-277, 2005.","DOI":"10.1093\/intimm\/dxh366"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Toulza F, Nosaka K, Takiguchi M, et al. Foxp3+ regulatory T cells are distinct from leukemia cells in HTLV-1 associated adult T-cell leukemia. Int J Cancer 25: 2375-2382, 2009.","DOI":"10.1002\/ijc.24664"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Yamano Y, Nagai M, Brennan M, et al. Correlation of human T-cell lymphotropic virus type 1 (HTLV-1) mRNA with proviral DNA load, virus-specific CD8+ T cells, and disease severity in HTLV-1-associated myelopathy (HAM\/TSP). Blood 99: 88-94, 2002.","DOI":"10.1182\/blood.V99.1.88"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Sugimoto M, Nakashima H, Watanabe S, et al. T-lymphocyte alveolitis in HTLV-1-associated myelopathy. Lancet 21: 1220, 1987.","DOI":"10.1016\/S0140-6736(87)91362-6"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Okada F, Ando Y, Yoshitake S, et al. Pulmonary CT findings in 320 carriers of human T-lymphotropic virus type 1. Radiology 240: 559-564, 2006.","DOI":"10.1148\/radiol.2402050886"},{"key":"29","unstructured":"29. Yamashiro T, Kamiya H, Miyara T, et al. CT scans of the chest in carriers of human T-cell lymphotropic virus type 1: presence of interstitial pneumonia. Acad Radiol 19: 952-957, 2012."},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Matsuse T, Fukuchi Y, Hsu CY, et al. Detection of human T lymphotropic virus type 1 proviral DNA in patients with diffuse pan bronchiolitis. Respirology 1: 139-144, 1996.","DOI":"10.1111\/j.1440-1843.1996.tb00023.x"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Yamamoto M, Matsuyama W, Oonakahara K, et al. Influence of human T lymphotropic virus type 1 on diffuse pan-bronchiolitis. Clin Exp Immunol 136: 513-520, 2004.","DOI":"10.1111\/j.1365-2249.2004.02485.x"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Kadota J, Mukae H, Fujii T, Seki M, Tomono K, Kohno S. Clinical similarities and differences between human T-cell lymphotropic type-1 associated bronchiolitis and diffuse panbronchiolitis. Chest 125: 1239-1247, 2004.","DOI":"10.1378\/chest.125.4.1239"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. American Thoracic Society, European Respiratory Society. American Thoracic Society\/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. Am J Respir Crit Care Med 165: 277-304, 2002.","DOI":"10.1164\/ajrccm.165.2.ats01"},{"key":"34","unstructured":"34. Silva Cl, M&uuml;ller NL, Hansell DM, Lee KS, Nicholson AG, Wells AU. Nonspecific interstitial pneumonia and idiopathic pulmonary fibrosis: changes in pattern and distribution of disease over time. Radiology 247: 251-259, 2008."},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Richardson JH, Edwards AJ, Cruickshank JK, Rudge P, Dalgleish AG. <i>In vivo<\/i> cellular tropism of human T-cell leukemia virus type 1. J Virol 64: 5682-5687, 1990.","DOI":"10.1007\/978-3-642-75924-6_30"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Hattori T, Uchiyama T, Toibana T, Takatsuki K, Uchino H. Surface phenotype of Japanese adult T-cell leukemia cells characterized by monoclonal antibodies. Blood 58: 645-647, 1981.","DOI":"10.1182\/blood.V58.3.645.bloodjournal583645"},{"key":"37","unstructured":"37. Fujita J, Ohtsuki Y, Yoshinouchi T, et al. Idiopathic non-specific interstitial pneumonia: as an \"autoimmune interstitial pneumonia\". Respir Med 99: 234-240, 2005."},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Ishii H, Mukae H, Kadota J, et al. High serum concentrations of surfactant protein A in usual interstitial pneumonia compared with non-specific interstitial pneumonia. Thorax 58: 52-57, 2003.","DOI":"10.1136\/thorax.58.1.52"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Ishii H, Mukae H, Kadota J, et al. Increased levels of interleukin-18 in bronchoalveolar lavage fluid of patients with idiopathic nonspecific interstitial pneumonia. Respiration 72: 39-45, 2005.","DOI":"10.1159\/000083399"},{"key":"40","unstructured":"40. Taylor JM, Nicot C. HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches. Apoptosis 13: 733-747, 2008."},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057-1061, 2003.","DOI":"10.1126\/science.1079490"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Fontenot JD, Gavin MA, Rundensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 4: 330-336, 2003.","DOI":"10.1038\/ni904"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Satou Y, Utsunomiya A, Tanabe J, Nakagawa M, Nosaka K, Matsuoka M. HTLV-1 modulates the frequency and phenotype of FoxP3+CD4+T cells in virus-infected individuals. Retrovirology 9: 46, 2012.","DOI":"10.1186\/1742-4690-9-46"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Miyazato A, Kawakami K, Iwakura Y, et al. Chemokine synthesis and cellular inflammatory changes in lungs of mice bearing p40tax of human T-lymphotropic virus type 1. Clin Exp Immunol 120: 113-124, 2000.","DOI":"10.1046\/j.1365-2249.2000.01197.x"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Kawakami K, Miyazato A, Iwakura Y, Saito A. Induction of lymphocytic inflammatory changes in lung institium by human T lymphotropic virus type 1. Am J Respir Crit Care Med 160: 995-1000, 1999.","DOI":"10.1164\/ajrccm.160.3.9808125"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. O'Garra A, Barrat FJ, Castro AG, Vicari A, Hawrylowicz C. Strategies for use of IL-10 or its antagonists in human disease. Immunol Rev 223: 114-131, 2008.","DOI":"10.1111\/j.1600-065X.2008.00635.x"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Roncarolo MG, Gregori S, Battaglia M, Bacchetta R, Fleischhauer K, Levings MK. Interleukin-10-secreting type 1 regulatory T cells in rodents and humans. Immunol Rev 212: 28-50, 2006.","DOI":"10.1111\/j.0105-2896.2006.00420.x"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. Carvalho EM, Bacellar O, Porto AF, Braga S, Galv&atilde;o-Castro B, Neva F. Cytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors. J Acquir Immune Defic Syndr 27: 1-6, 2001.","DOI":"10.1097\/00126334-200105010-00001"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Atsumi E, Yara S, Higa F, et al. Influence of human T lymphotropic virus type 1 infection on the etiology of community-acquired pneumonia. 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