{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:21:59Z","timestamp":1793294519067,"version":"4.5.0"},"reference-count":25,"publisher":"Japanese Society of Internal Medicine","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2013]]},"DOI":"10.2169\/internalmedicine.52.9472","type":"journal-article","created":{"date-parts":[[2013,6,14]],"date-time":"2013-06-14T23:02:04Z","timestamp":1371250924000},"page":"1317-1323","source":"Crossref","is-referenced-by-count":140,"title":["Pulmonary Tumor Thrombotic Microangiopathy: A Clinical Analysis of 30 Autopsy Cases"],"prefix":"10.2169","volume":"52","author":[{"given":"Hironori","family":"Uruga","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Respiratory Center, Toranomon Hospital, Japan"},{"name":"Okinaka Memorial Institute for Medical Research, Japan"},{"name":"Department of Respiratory Medicine, Toho University Omori Medical Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Pathology, Toranomon Hospital, Japan"},{"name":"Okinaka Memorial Institute for Medical Research, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuko","family":"Kurosaki","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Toranomon Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Hanada","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Respiratory Center, Toranomon Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Takaya","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Respiratory Center, Toranomon Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Respiratory Center, Toranomon Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasa","family":"Morokawa","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Respiratory Center, Toranomon Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakae","family":"Homma","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Toho University Omori Medical Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuma","family":"Kishi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Respiratory Center, Toranomon Hospital, Japan"},{"name":"Okinaka Memorial Institute for Medical Research, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. von Herbay A, Illes A, Waldherr R, Otto HF. Pulmonary tumor thrombotic microangiopathy with pulmonary hypertension. Cancer 66: 587-592, 1999.","DOI":"10.1002\/1097-0142(19900801)66:3<587::AID-CNCR2820660330>3.0.CO;2-J"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Chinen K, Kazumoto T, Ohkura Y, Matsubara O, Tsuchiya E. Pulmonary tumor thrombotic microangiopathy caused by a gastric carcinoma expressing vascular endothelial growth factor and tissue factor. Pathol Int 55: 27-31, 2005.","DOI":"10.1111\/j.1440-1827.2005.01783.x"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Kerbel RS. Tumor angiogenesis. N Engl J Med 358: 2039-2049, 2008.","DOI":"10.1056\/NEJMra0706596"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Takahashi F, Kumasaka T, Nagaoka T, et al. Osteopontin expression in pulmonary tumor thrombotic microangiopathy caused by gastric carcinoma. Pathol Int 59: 752-756, 2009.","DOI":"10.1111\/j.1440-1827.2009.02439.x"},{"key":"5","unstructured":"5. Uruga H, Fujii T, Kurosaki A, et al. A case of pulmonary tumor thrombotic microangiopathy caused by carcinoma (salivary duct carcinoma) ex pleomorphic adenoma. Nihon Kokyuki Gakkai Zasshi 48: 463-468, 2010 (In Japanese, Abstract in English)."},{"key":"6","unstructured":"6. Uruga H, Morokawa N, Enomoto T, et al. A case of pulmonary tumor thrombotic microangiopathy associated with lung adenocarcinoma diagnosed by CT-guided lung biopsy. Nihon Kokyuki Gakkai Zasshi 46: 928-933, 2008 (In Japanese, Abstract in English)."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Hibbert M, Braude S. Tumour microembolism presenting as \"primary pulmonary hypertension\". Thorax 52: 1016-1017, 1997.","DOI":"10.1136\/thx.52.11.1016"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Gavin MC, Morse D, Partridge AH, Levy BD, Loscalzo J. Clinical problem-solving. Breathless. N Engl J Med 366: 75-81, 2012.","DOI":"10.1056\/NEJMcps1011918"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Miyano S, Izumi S, Takeda Y, et al. Pulmonary tumor thrombotic microangiopathy. J Clin Oncol 25: 597-599, 2007.","DOI":"10.1200\/JCO.2006.09.0670"},{"key":"10","unstructured":"10. Ota K, Matsuyama M, Kokuho N, et al. An autopsy case of pulmonary tumor thrombotic microangiopathy complicated with interstitial pneumonia and lipoid pneumonia. Nihon Kokyuki Gakkai Zasshi 47: 518-523, 2009 (In Japanese, Abstract in English)."},{"key":"11","unstructured":"11. Ishiguro T, Takayanagi N, Ando M, Yanagisawa T, Shimizu Y, Sugita Y. Pulmonary tumor thrombotic microangiopathy responding to chemotherapy. Nihon Kokyuki Gakkai Zasshi 49: 681-687, 2011 (In Japanese, Abstract in English)."},{"key":"12","unstructured":"12. Noguchi S, Imanaga T, Shimizu M, Nakano T, Miyazaki N. Case of pulmonary tumor thrombotic microangiopathy diagnosed by transbronchial lung biopsy. Nihon Kokyuki Gakkai Zasshi 46: 493-496, 2008 (In Japanese, Abstract in English)."},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Ueda A, Fuse N, Fujii S, et al. Pulmonary tumor thrombotic microangiopathy associated with esophageal squamous cell carcinoma. Intern Med 50: 2807-2810, 2011.","DOI":"10.2169\/internalmedicine.50.6113"},{"key":"14","unstructured":"14. Franquet T, Gimenez A, Prats R, Rodriguez-Arias JM, Rodriguez C. Thrombotic microangiopathy of pulmonary tumors: a vascular cause of tree-in-bud pattern on CT. AJR Am J Roentgenol 179: 897-899, 2002."},{"key":"15","unstructured":"15. Guimaraes MD, Almeida MF, Brelinger A, Barbosa PN, Chojniak R, Gross JL. Diffuse bronchiolitis pattern on a computed tomography scan as a presentation of pulmonary tumor thrombotic microangiopathy: a case report. J Med Case Rep 5: 575, 2011."},{"key":"16","unstructured":"16. Tashima Y, Abe K, Matsuo Y, et al. Pulmonary tumor thrombotic microangiopathy: FDG-PET\/CT findings. Clin Nucl Med 34: 175-177, 2009."},{"key":"17","unstructured":"17. Kinuya K, Yamanouchi K, Terahata S. Diagnosis: pulmonary tumor thrombotic microangiopathy developing cor pulmonale. Ann Nucl Med 16: 220, 2002."},{"key":"18","unstructured":"18. Tamura A, Matsubara O. Pulmonary tumor embolism: relationship between clinical manifestations and pathologic findings. Nihon Kyobu Shikkan Gakkai Zasshi 31: 1269-1278, 1993 (In Japanese, Abstract in English)."},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. de Vries C, Escobedo JA, Ueno H, Houck K, Ferrara N, Williams LT. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255: 989-991, 1992.","DOI":"10.1126\/science.1312256"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Shibuya M, Claesson-Welsh L. Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Exp Cell Res 312: 549-560, 2006.","DOI":"10.1016\/j.yexcr.2005.11.012"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Kasthuri RS, Taubman MB, Mackman N. Role of tissue factor in cancer. J Clin Oncol 27: 4834-4838, 2009.","DOI":"10.1200\/JCO.2009.22.6324"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Levi M. Disseminated intravascular coagulation in cancer patients. Best Pract Res Clin Haematol 22: 129-136, 2009.","DOI":"10.1016\/j.beha.2008.12.005"},{"key":"23","unstructured":"23. Chinen K, Tokuda Y, Fujiwara M, Fujioka Y. Pulmonary tumor thrombotic microangiopathy in patients with gastric carcinoma: an analysis of 6 autopsy cases and review of the literature. Pathol Res Pract 206: 682-689, 2010."},{"key":"24","unstructured":"24. Okubo Y, Wakayama M, Kitahara K, et al. Pulmonary tumor thrombotic microangiopathy induced by gastric carcinoma: morphometric and immunohistochemical analysis of six autopsy cases. Diagn Pathol 6: 27, 2011."},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Sato Y, Marutsuka K, Asada Y, Yamada M, Setoguchi T, Sumiyoshi A. Pulmonary tumor thrombotic microangiopathy. Pathol Int 45: 436-440, 1995.","DOI":"10.1111\/j.1440-1827.1995.tb03481.x"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/52\/12\/52_52.9472\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T17:49:43Z","timestamp":1621446583000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/52\/12\/52_52.9472\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.52.9472","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}