{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:25:17Z","timestamp":1759962317635},"reference-count":15,"publisher":"Japanese Society of Internal Medicine","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2013]]},"DOI":"10.2169\/internalmedicine.52.9574","type":"journal-article","created":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T22:56:52Z","timestamp":1368572212000},"page":"1035-1041","source":"Crossref","is-referenced-by-count":5,"title":["Inhibition of Calcium&lt;sup&gt;2+&lt;\/sup&gt;\/Calmodulin-dependent Protein Kinase Type IV Ameliorates Experimental Nephrotic Syndrome"],"prefix":"10.2169","volume":"52","author":[{"given":"Qiangguo","family":"Ao","sequence":"first","affiliation":[{"name":"Department of Geriatric Nephrology, Institute of Gerontology, Chinese PLA General Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingli","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Geriatric Nephrology, Institute of Gerontology, Chinese PLA General Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Geriatric Nephrology, Institute of Gerontology, Chinese PLA General Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Geriatric Nephrology, Institute of Gerontology, Chinese PLA General Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Geriatric Nephrology, Institute of Gerontology, Chinese PLA General Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Somlo S, Mundel P. Getting a foothold in nephrotic syndrome. Nat Genet 24: 333-335, 2000.","DOI":"10.1038\/74139"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Reiser J, von Gersdorff G, Loos M, et al. Induction of B7-1 in podocytes is associated with nephrotic syndrome. J Clin Invest 113: 1390-1397, 2004.","DOI":"10.1172\/JCI200420402"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Kriz W, Gretz N, Lemley KV. Progression of glomerular diseases: is the podocyte the culprit? Kidney Int 54: 687-697, 1998.","DOI":"10.1046\/j.1523-1755.1998.00044.x"},{"key":"4","unstructured":"4. Ichinose K, Rauen T, Juang YT, et al. Cutting edge: Calcium\/Calmodulin-dependent protein kinase type IV is essential for mesangial cell proliferation and lupus nephritis. J Immunol 187: 5500-5504, 2011."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Ichinose K, Juang YT, Crisp&iacute;n JC, Kis-Toth K, Tsokos GC. Suppression of autoimmunity and organ pathology in lupus-prone mice upon inhibition of calcium\/calmodulin-dependent protein kinase type IV. Arthritis Rheum 63: 523-529, 2011.","DOI":"10.1002\/art.30085"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Remuzzi G, Benigni A, Remuzzi A. Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes. J Clin Invest 116: 288-296, 2006.","DOI":"10.1172\/JCI27699"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Kairaitis L, Wang Y, Zheng L, Tay YC, Wang Y, Harris DC. Blockade of CD40-CD40 ligand protects against renal injury in chronic proteinuric renal disease. Kidney Int 64: 1265-1272, 2003.","DOI":"10.1046\/j.1523-1755.2003.00223.x"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Kikawada E, Lenda DM, Kelley VR. IL-12 deficiency in MRL-<i>Fas<\/i><sup>lpr<\/sup> mice delays nephritis and intrarenal IFN-&gamma; expression, and diminishes systemic pathology. J Immunol 170: 3915-3925, 2003.","DOI":"10.4049\/jimmunol.170.7.3915"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Sadanaga A, Nakashima H, Akahoshi M, et al. Protection against autoimmune nephritis in MyD88-deficient MRL\/lpr mice. Arthritis Rheum 56: 1618-1628, 2007.","DOI":"10.1002\/art.22571"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Burton CJ, Combe C, Walls J, Harris KP. Secretion of chemokines and cytokines by human tubular epithelial cells in response to proteins. Nephrol Dial Transplant 14: 2628-2633, 1999.","DOI":"10.1093\/ndt\/14.11.2628"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Shimizu H, Maruyama S, Yuzawa Y, et al. Anti-monocyte chemoattractant protein-1 gene therapy attenuates renal injury induced by protein-overload proteinuria. J Am Soc Nephrol 14: 1496-1505, 2003.","DOI":"10.1097\/01.ASN.0000069223.98703.8E"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Wang Y, Mahajan D, Tay YC, et al. Partial depletion of macrophages by ED7 reduces renal injury in Adriamycin nephropathy. Nephrology (Carlton) 10: 470-477, 2005.","DOI":"10.1111\/j.1440-1797.2005.00438.x"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Wang Y, Wang YP, Tay YC, Harris DC. Role of CD8<sup>+<\/sup> cells in the progression of murine adriamycin nephropathy. Kidney Int 59: 941-949, 2001.","DOI":"10.1046\/j.1523-1755.2001.059003941.x"},{"key":"14","unstructured":"14. Johnson RJ, Iida H, Alpers CE, et al. Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis: &alpha;-smooth muscle actin is a marker of mesangial cell proliferation. J Clin Invest 87: 847-858, 1991."},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Nightingale J, Patel S, Suzuki N, et al. Oncostatin M, a cytokine released by activated mononuclear cells, induces epithelial cell-myofibroblast transdifferentiation via Jak\/Stat pathway activation. J Am Soc Nephrol 15: 21-32, 2004.","DOI":"10.1097\/01.ASN.0000102479.92582.43"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/52\/10\/52_52.9574\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T17:49:50Z","timestamp":1621446590000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/52\/10\/52_52.9574\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.52.9574","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}