{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T06:04:13Z","timestamp":1773813853488,"version":"3.50.1"},"reference-count":26,"publisher":"Japanese Society of Internal Medicine","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2014]]},"DOI":"10.2169\/internalmedicine.53.1137","type":"journal-article","created":{"date-parts":[[2014,5,31]],"date-time":"2014-05-31T23:22:11Z","timestamp":1401578531000},"page":"1159-1164","source":"Crossref","is-referenced-by-count":10,"title":["Acute Myeloid Leukemia Concurrent with Spinal Epidural Extramedullary Myeloid Sarcoma Accompanied by a High CD25 Expression and the &lt;i&gt;FLT3-ITD&lt;\/i&gt; Mutation"],"prefix":"10.2169","volume":"53","author":[{"given":"Yusuke","family":"Isshiki","sequence":"first","affiliation":[{"name":"Department of Hematology, Chiba University Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikako","family":"Ohwada","sequence":"additional","affiliation":[{"name":"Department of Hematology, Chiba University Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emi","family":"Togasaki","sequence":"additional","affiliation":[{"name":"Department of Hematology, Chiba University Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoh","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Chiba University Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagisa","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Hematology, Chiba University Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuko","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Hematology, Chiba University Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasumasa","family":"Sugita","sequence":"additional","affiliation":[{"name":"Department of Hematology, Chiba University Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeharu","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Chiba University Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shokichi","family":"Tsukamoto","sequence":"additional","affiliation":[{"name":"Department of Hematology, Chiba University Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shio","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Hematology, Chiba University Hospital, Japan"},{"name":"Division of Transfusion Medicine and Cell Therapy, Chiba University Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Hematology, Chiba University Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Chiba University Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiko","family":"Sakaida","sequence":"additional","affiliation":[{"name":"Department of Hematology, Chiba University Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Chiba University Hospital, Japan"},{"name":"Division of Transfusion Medicine and Cell Therapy, Chiba University Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Pathology, Chiba University Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koutaro","family":"Yokote","sequence":"additional","affiliation":[{"name":"Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Iseki","sequence":"additional","affiliation":[{"name":"Department of Hematology, Chiba University Hospital, Japan"},{"name":"Division of Transfusion Medicine and Cell Therapy, Chiba University Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiaki","family":"Nakaseko","sequence":"additional","affiliation":[{"name":"Department of Hematology, Chiba University Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Liu PI, Ishimaru T, McGregor DH, Okada H, Steer A. Autopsy study of granulocytic sarcoma (chloroma) in patients with myelogenous leukemia, Hiroshima-Nagasaki 1949-1969. Cancer 31: 948-955, 1973.","DOI":"10.1002\/1097-0142(197304)31:4<948::AID-CNCR2820310428>3.0.CO;2-N"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Muss HB, Moloney WC. Chloroma and other myeloblastic tumors. Blood 42: 721-728, 1973.","DOI":"10.1182\/blood.V42.5.721.721"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Shimizu H, Saitoh T, Hatsumi N, et al. Clinical significance of granulocytic sarcoma in adult patients with acute myeloid leukemia. Cancer Sci 103: 1513-1517, 2012.","DOI":"10.1111\/j.1349-7006.2012.02324.x"},{"key":"4","unstructured":"4. Paydas S, Zorludemir S, Ergin M. Granulocytic sarcoma: 32 cases and review of the literature. Leuk Lymphoma 47: 2527-2541, 2006."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Bakst RL, Tallman MS, Douer D, Yahalom J. How I treat extramedullary acute myeloid leukemia. Blood 118: 3785-3793, 2011.","DOI":"10.1182\/blood-2011-04-347229"},{"key":"6","unstructured":"6. Krause JR. Granulocytic sarcoma preceding acute leukemia: a report of six cases. Cancer 44: 1017-1021, 1979."},{"key":"7","unstructured":"7. Inoue D, Nagai Y, Kimura T, et al. Refractory de novo myeloid sarcoma: a case report and therapeutic strategy based on bone marrow minimal residual disease. Int J Hematol 90: 120-123, 2009."},{"key":"8","unstructured":"8. Menasce LP, Banerjee SS, Beckett E, Harris M. Extra-medullary myeloid tumour (granulocytic sarcoma) is often misdiagnosed: a study of 26 cases. Histopathology 34: 391-398, 1999."},{"key":"9","unstructured":"9. Pileri SA, Ascani S, Cox MC, et al. Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients. Leukemia 21: 340-350, 2007."},{"key":"10","unstructured":"10. Rigamonti F, Beris P, Sanchez-Pareja A, et al. Atypical presentation of acute myeloid leukemia: cardiac myeloid sarcoma. Int J Hematol 89: 693-698, 2009."},{"key":"11","unstructured":"11. Seok JH, Park J, Kim SK, Choi JE, Kim CC. Granulocytic sarcoma of the spine: MRI and clinical review. Am J Roentgenol 194: 485-489, 2010."},{"key":"12","unstructured":"12. Gonen M, Sun Z, Figueroa ME, et al. CD25 expression status improves prognostic risk classification in AML independent of established biomarkers: ECOG phase 3 trial, E1900. Blood 120: 2297-2306, 2012."},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Terwijn M, Feller N, van Rhenen A, et al. Interleukin-2 receptor alpha-chain (CD25) expression on leukaemic blasts is predictive for outcome and level of residual disease in AML. Eur J Cancer 45: 1692-1699, 2009.","DOI":"10.1016\/j.ejca.2009.02.021"},{"key":"14","unstructured":"14. Kindler T, Lipka DB, Fischer T. FLT3 as a therapeutic target in AML: still challenging after all these years. Blood 116: 5089-5102, 2010."},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Saito Y, Kitamura H, Hijikata A, et al. Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells. Sci Transl Med 2: 17ra19, 2010.","DOI":"10.1126\/scitranslmed.3000349"},{"key":"16","unstructured":"16. Nakase K, Kita K, Kageyama S, et al. Clinical importance of interleukin-2 receptor alpha-chain expression in acute leukemia. The Japan Cooperative Group of Leukemia\/Lymphoma. Cancer Detect Prev 21: 273-279, 1997."},{"key":"17","unstructured":"17. Takeda M, Yamaguchi S, Eguchi K, et al. Spinal epidural granulocytic sarcoma in a child precedent to clinical manifestation of acute myeloid lymphoma: case report. Neurol Med Chir (Tokyo) 49: 221-224, 2009."},{"key":"18","unstructured":"18. Nakase K, Kita K, Kyo T, Tsuji K, Katayama N. High serum levels of soluble interleukin-2 receptor in acute myeloid leukemia: correlation with poor prognosis and CD4 expression on blast cells. Cancer Epidemiol 36: e306-e309, 2012."},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Yoshida N, Oda M, Kuroda Y, et al. Clinical significance of sIL-2R levels in B-cell lymphomas. PLoS One 8: e78730, 2013.","DOI":"10.1371\/journal.pone.0078730"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Ansari-Lari MA, Yang CF, Tinawi-Aljundi R, et al. FLT3 mutations in myeloid sarcoma. Br J Haematol 126: 785-791, 2004.","DOI":"10.1111\/j.1365-2141.2004.05124.x"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Meis JM, Butler JJ, Osborne BM, Manning JT. Granulocytic sarcoma in nonleukemic patients. Cancer 58: 2697-2709, 1986.","DOI":"10.1002\/1097-0142(19861215)58:12<2697::AID-CNCR2820581225>3.0.CO;2-R"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Hayashi T, Kimura M, Satoh S, et al. Early detection of AML1\/MTG8 fusion mRNA by RT-PCR in the bone marrow cells from a patient with isolated granulocytic sarcoma. Leukemia 12: 1501-1503, 1998.","DOI":"10.1038\/sj.leu.2401118"},{"key":"23","unstructured":"23. Chevallier P, Mohty M, Lioure B, et al. Allogeneic hematopoietic stem-cell transplantation for myeloid sarcoma: a retrospective study from the SFGM-TC. J Clin Oncol 26: 4940-4943, 2008."},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Shimizu H, Saitoh T, Tanaka M, et al. Allogeneic hematopoietic stem cell transplantation for adult AML patients with granulocytic sarcoma. Leukemia 26: 2469-2473, 2012.","DOI":"10.1038\/leu.2012.156"},{"key":"25","unstructured":"25. Chak LY, Sapozink MD, Cox RS. Extramedullary lesions in non-lymphocytic leukemia: results of radiation therapy. Int J Radiat Oncol Biol Phys 9: 1173-1176, 1983."},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Tsimberidou AM, Kantarjian HM, Estey E, et al. Outcome in patients with nonleukemic granulocytic sarcoma treated with chemotherapy with or without radiotherapy. Leukemia 17: 1100-1103, 2003.","DOI":"10.1038\/sj.leu.2402958"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/53\/11\/53_53.1137\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T17:50:20Z","timestamp":1621446620000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/53\/11\/53_53.1137\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":26,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.53.1137","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}