{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:42:19Z","timestamp":1787024539006,"version":"build-2736575974"},"reference-count":15,"publisher":"Japanese Society of Internal Medicine","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2014]]},"DOI":"10.2169\/internalmedicine.53.1386","type":"journal-article","created":{"date-parts":[[2014,2,14]],"date-time":"2014-02-14T17:58:16Z","timestamp":1392400696000},"page":"315-319","source":"Crossref","is-referenced-by-count":3,"title":["Refractory High Output Heart Failure in a Patient with Primary Mitochondrial Respiratory Chain Disease"],"prefix":"10.2169","volume":"53","author":[{"given":"Hitoshi","family":"Nakagawa","sequence":"first","affiliation":[{"name":"First Department of Internal Medicine, Nara Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Okayama","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Nara Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Kamon","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Nara Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Nakano","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Nara Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Onoue","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Nara Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rika","family":"Kawakami","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Nara Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Horii","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Nara Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Sakaguchi","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Nara Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Uemura","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Nara Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genzou","family":"Takemura","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Gifu University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Saito","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Nara Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Limongelli G, Tome-Esteban M, Dejthevaporn C, Rahman S, Hanna MG, Elliott PM. Prevalence and natural history of heart disease in adults with primary mitochondrial respiratory chain disease. Eur J Heart Fail 12: 114-121, 2010.","DOI":"10.1093\/eurjhf\/hfp186"},{"key":"2","unstructured":"2. Bates MG, Bourke JP, Giordano C, d'Amati G, Turnbull DM, Taylor RW. Cardiac involvement in mitochondrial DNA disease: clinical spectrum, diagnosis, and management. Eur Heart J 33: 3023-3033, 2012."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Okayama S, Uemura S, Saito Y. Evaluation of epicardial and intra-myocardial fat in a patient with mitochondrial cardiomyopathy. Int J Cardiol 167: e43-e45, 2013.","DOI":"10.1016\/j.ijcard.2013.03.054"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Tsujita Y, Kunitomo T, Fujii M, et al. A surviving case of mitochondrial cardiomyopathy diagnosed from the symptoms of multiple organ dysfunction syndrome. Int J Cardiol 128: e43-e45, 2008.","DOI":"10.1016\/j.ijcard.2007.05.072"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Partington SL, Givertz MM, Gupta S, Kwong RY. Cardiac magnetic resonance aids in the diagnosis of mitochondrial cardiomyopathy. Circulation 123: e227-e229, 2011.","DOI":"10.1161\/CIRCULATIONAHA.110.973305"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Mastaglia FL, Thompson PL, Papadimitriou JM. Mitochondrial myopathy with cardiomyopathy, lactic acidosis and response to prednisone and thiamine. Aust NZ J Med 10: 660-664, 1980.","DOI":"10.1111\/j.1445-5994.1980.tb04250.x"},{"key":"7","unstructured":"7. Hirose Y, Miida T, Yoshida K, et al. High-output heart failure in mitochondrial myopathy: a fulminant form with severe lactic acidosis and rhabdomyolysis. Intern Med 32: 798-801, 1993."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Inoue S, Nagayama M, Aoki H, et al. Continuous venovenous hemodiafiltration for life-threatening mitochondrial myopathy with lactic acidosis and rhabdomyolysis. J Intensive Care Med 22: 240-244, 2007.","DOI":"10.1177\/0885066607301343"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Mehta PA, Dubrey SW. High output heart failure. QJM 102: 235-241, 2009.","DOI":"10.1093\/qjmed\/hcn147"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Okura H, Takatsu Y. High-output heart failure as a cause of pulmonary hypertension. Intern Med 33: 363-365, 1994.","DOI":"10.2169\/internalmedicine.33.363"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Khalid SK, Pershbacher J, Makan M, Barzilai B, Goodenberger D. Worsening of nose bleeding heralds high cardiac output state in hereditary hemorrhagic telangiectasia. Am J Med 122: e1-e9, 2009.","DOI":"10.1016\/j.amjmed.2009.01.037"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Koyalakonda SP, Pyatt J. High output heart failure caused by a large pelvic arteriovenous malformation. JRSM Short Rep 2: 66, 2011.","DOI":"10.1258\/shorts.2011.011057"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Mori K, Nakaya Y, Sakamoto S, Hayabuchi Y, Matsuoka S, Kuroda Y. Lactate-induced vascular relaxation in porcine coronary arteries is mediated by Ca<sup>2+<\/sup>-activated K<sup>+<\/sup> channels. J Mol Cell Cardiol 30: 349-356, 1998.","DOI":"10.1006\/jmcc.1997.0598"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Suzuki S. Diabetes mellitus with mitochondrial gene mutations in Japan. Ann NY Acad Sci 1011: 185-192, 2004.","DOI":"10.1196\/annals.1293.019"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Rodriguez MC, MacDonald JR, Mahoney DJ, Parise G, Beal MF, Tarnopolsky MA. Beneficial effects of creatine, CoQ10, and lipoic acid in mitochondrial disorders. Muscle Nerve 35: 235-242, 2007.","DOI":"10.1002\/mus.20688"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/53\/4\/53_53.1386\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T13:50:43Z","timestamp":1621432243000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/53\/4\/53_53.1386\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.53.1386","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}