{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T04:27:59Z","timestamp":1747801679899},"reference-count":36,"publisher":"Japanese Society of Internal Medicine","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2014]]},"DOI":"10.2169\/internalmedicine.53.1713","type":"journal-article","created":{"date-parts":[[2014,4,14]],"date-time":"2014-04-14T23:11:25Z","timestamp":1397517085000},"page":"851-858","source":"Crossref","is-referenced-by-count":6,"title":["Primary Intestinal Follicular Lymphoma and Premature Atherosclerosis in a Japanese Diabetic Patient with Atypical Familial Partial Lipodystrophy"],"prefix":"10.2169","volume":"53","author":[{"given":"Masanori","family":"Iwanishi","sequence":"first","affiliation":[{"name":"Department of Diabetes and Endocrinology, Kusatsu General Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Ebihara","sequence":"additional","affiliation":[{"name":"Institute for Advancement of Clinical and Translational Science, Kyoto University Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Kusakabe","sequence":"additional","affiliation":[{"name":"Medical Innovation Center, Kyoto University Graduate School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Washiyama","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Kusatsu General Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Ito-Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Kusatsu General Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiyasu","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kusatsu General Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Togawa","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery, Kusatsu General Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Ozamoto","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery, Kusatsu General Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akeo","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery, Kusatsu General Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuwa","family":"Nakao","sequence":"additional","affiliation":[{"name":"Medical Innovation Center, Kyoto University Graduate School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Garg A. Acquired and inherited lipodystrophies. N Engl J Med 350: 1220-1234, 2004.","DOI":"10.1056\/NEJMra025261"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Agarwal AK, Garg A. Genetic disorders of adipose tissue development, differentiation and death. Annu Rev Genomics Hum Genet 7: 175-199, 2006.","DOI":"10.1146\/annurev.genom.7.080505.115715"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Agarwal AK, Garg A. Genetic basis of lipodystrophies and management of metabolic complications. Annu Rev Med 57: 297-311, 2006.","DOI":"10.1146\/annurev.med.57.022605.114424"},{"key":"4","unstructured":"4. Garg A. Lipodystrophies: Genetic and acquired body fat disorders. J Clin Endocrinol Metab 96: 3313-3325, 2011."},{"key":"5","unstructured":"5. Dunnigan MG, Cochrane MA, Kelly A, Scott JW. Familial lipoatrophic diabetes with dominant transmission. Quarterly Journal of Medicine 169: 33-48, 1974."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Handelsman Y, Oral EA, Bloomgarden ZT, et al. The clinical approach to the detection of lipodystrophy an aace consensus statement. Endocr Pract 19: 107-116, 2013.","DOI":"10.4158\/endp.19.1.v767575m65p5mr06"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Vantyghem MC, Balavoine AS, Douillard C, et al. How to diagnose a lipodystrophy syndrome. Annales of Endocrinologie 73: 170-189, 2012.","DOI":"10.1016\/j.ando.2012.04.010"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Visser ME, Kropman E, Kranendonk ME. Characterisation of non-obese diabetic patients with marked insulin resistance identifies a novel familial partial lipodystrophy-associated PPARgamma mutation (Y151C). Diabetogia 54: 1639-1644, 2011.","DOI":"10.1007\/s00125-011-2142-4"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Ciudin A, Baena-Fustegueras JA, Fort JM, Encabo G, Lecube A. Successful treatment of the Dunnigan-type familial partial lipodystrophy with Roux-en-Y gastric bypass. Clinical Endocrinol 75: 403-404, 2011.","DOI":"10.1111\/j.1365-2265.2011.04057.x"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Utzschneider KM, Trence DL. Effectiveness of gastric bypass surgery in a patient with familial partial lipodystrophy. Diabetes Care 6: 1380-1382, 2006.","DOI":"10.2337\/dc06-0130"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. McGrath NM, FRACP M, Krishna G; MBChB, FRACS. Gastric bypass for insulin resistance due to lipodystrophy. Obes Surg 16: 1542-1544, 2006.","DOI":"10.1381\/096089206778869988"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Joy T, Kennedy BA, Al-Attar S, Rutt BK, Hegele RA. Predicting abdominal adipose tissue among women with familial partial lipodystrophy. Metabolism 58: 828-834, 2009.","DOI":"10.1016\/j.metabol.2009.03.001"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Mory PB, Crispim F, Freire MB, et al. Phenotypic diversity in patients with lipodystrophy associated with LMNA mutations. Eur J Endocrinol 167: 423-431, 2012.","DOI":"10.1530\/EJE-12-0268"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Haque WA, Shimomura I, Matsuzawa Y, Garg A. Serum adiponectin and leptin levels in patients in patients with lipodystrophies. J Clin Endocrinol Metab 87: 2395-2398, 2002.","DOI":"10.1210\/jcem.87.5.8624"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. McDuffie JR, Riggs PA, Calis KA, et al. Effects of exogenous leptin on satiety and satiation in patients with lipodystrophy and leptin insufficieny. J Clin Endocrinol Metab 89: 4258-4263, 2004.","DOI":"10.1210\/jc.2003-031868"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Aotani D, Ebihara K, Sawamoto N, et al. Functional magnetic resonance imaging analysis of food-related brain activity in patients with lipodystrophy undergoing leptin replacement therapy. J Clin Endocrinol Metab 97: 3663-3671, 2012.","DOI":"10.1210\/jc.2012-1872"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Hotta K, Funahashi T, Arita Y, et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 20: 1595-1599, 2000.","DOI":"10.1161\/01.ATV.20.6.1595"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Ebihara K, Kusakabe T, Hirata M, et al. Efficacy and safety of leptin-replacement therapy and possible mechanisms of leptin actions in patients with generalized lipodystrophy. J Clin Endocrinol Metab 92: 532-541, 2007.","DOI":"10.1210\/jc.2006-1546"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Moon HS, Dalamaga M, Kim SY, et al. Leptin's role in lipodystrophic and nonlipodystrophic insulin-resistant and diabetic individuals. Endocrine Reviews 34: 1-36, 2013.","DOI":"10.1210\/er.2012-1053"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Gavrilova O, Marcus-Samuels B, Graham D, et al. Surgical implantation of adipose tissue reverses diabetes in lipostrophic mice. J Clin Invest 105: 271-278, 2000.","DOI":"10.1172\/JCI7901"},{"key":"21","unstructured":"21. Dalamaga M, Diakopoulos KN, Mantzoros CS. The role of adiponectin in cancer: A review of current evidence. Endocrine Reviews 33: 547-594, 2012."},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Bao Y, Giovannucci EL, Stampfer MJ, et al. A prospective study of plasma adiponectin and pancreatic cancer risk in five US cohorts. J Natl Cancer Inst 105: 95-103, 2013.","DOI":"10.1093\/jnci\/djs474"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Mutoh M, Teraoka N, Takasu S, et al. Loss of adiponectin promotes intestinal carcinogenesis in min and wild-type mice. Gastroenterology 140: 2000-2008, 2011.","DOI":"10.1053\/j.gastro.2011.02.019"},{"key":"24","unstructured":"24. Matsumoto N, Suehio T, Nishiyama M, et al. A family with lipoatrophic diabetes, high frequency of type 2 diabetes mellitus nd cancer in the digestive organs. J. Japan Diab. Soc 43: 51-56, 2000."},{"key":"25","unstructured":"25. Franceschini P, Barisone E, Signorile F, et al. Pre-B acute lymphoblastic leukemia in a patient with partial lipodystrophy and acanthosis nigricans. Panminerva Med 37: 248-251, 1995."},{"key":"26","unstructured":"26. Shinkawa K, Nishikawa H, Mori T, Kawai H, Yoshida Y. Case of congenital generalized lipodystrophy associated with papillary serous cysadenocarcinoma. Horumon To Rinsho 25: 888-895, 1977 (in Japanese)."},{"key":"27","unstructured":"27. Conroy SM, Maskarinec G, Morimoto Y, et al. Non-Hodgkin lymphoma and circulating markers of inflammation and adiposity in a nested case-control study: The multiethnic cohort. Cancer Epidemiol Biomarkers Prev 1: 1-24, 2013."},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Bereziat V, Cervera P, Le Dour C, et al; the Lipodystrophy Study Group. LMNA mutations induce a non-inflammatory fibrosis and a brown fat-like dystrophy of enlarged cervical adipose tissue. Am J Pathol 179: 2443-2453, 2011.","DOI":"10.1016\/j.ajpath.2011.07.049"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Gandotra S, Dour CL, Bottomley W, et al. Perilipin deficiency and autosomal dominant partial lipodystrophy. N Engl J Med 364: 740-748, 2011.","DOI":"10.1056\/NEJMoa1007487"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Garg A. Gender differences in the prevalence of metabolic complications in familial partial lipodystrophy (Dunnigan variety). J Clin Endocrinol Metab 85: 1776, 2000.","DOI":"10.1210\/jcem.85.5.6605"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Hegele RA. Premature atherosclerosis associated with monogenic insulin resistance. Circulation 103: 2225-2229, 2001.","DOI":"10.1161\/01.CIR.103.18.2225"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Bidault G, Garcia M, Vantyghem M-C, et al. Lipodystrophy-linked LMNA p.R482W mutation induces clinical early atherosclerosis and in vitro endothelial dysfunction. Arterioscler Thromb Vasc Biol 33: 1-10, 2013.","DOI":"10.1161\/ATVBAHA.113.301933"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Auclair M, Vigouroux C, Boccara F, et al. Peroxisome proliferator-activated receptor-γmutations responsible for lipodystrophy with severe hypertension activate the cellular renin-angiotensin system. Arterioscler Thromb Vasc Biol 33: 829-838, 2013.","DOI":"10.1161\/ATVBAHA.112.300962"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Iwanishi M, Ebihara K, Kusakabe T, et al. Premature atherosclerosis in a japanese diabetic patient with atypical familial partial lipodystrophy and hypertriglyceridemia. Intern Med 51: 2573-2579, 2012.","DOI":"10.2169\/internalmedicine.51.7461"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Iwanishi M, Ebihara K, Kusakabe T, et al. Clinical characteristics and efficacy of pioglitazone in a Japanese diabetic patient with an unusual type of familial partial lipodystrophy. Metabolism 58: 1681-1687, 2009.","DOI":"10.1016\/j.metabol.2009.04.043"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Arioglu EA, Duncan-Morin J, Sebring N, et al. Efficacy and safety of troglitazone in the treatment of lipodystrophy syndromes. Ann Intern Med 133: 263-274, 2000.","DOI":"10.7326\/0003-4819-133-4-200008150-00009"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/53\/8\/53_53.1713\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T17:51:12Z","timestamp":1621446672000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/53\/8\/53_53.1713\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.53.1713","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}