{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:18:37Z","timestamp":1761513517358},"reference-count":23,"publisher":"Japanese Society of Internal Medicine","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2014]]},"DOI":"10.2169\/internalmedicine.53.2085","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T01:39:12Z","timestamp":1410831552000},"page":"2149-2152","source":"Crossref","is-referenced-by-count":5,"title":["<i>Clostridium difficile<\/i> Infection Induced by Pregabalin-associated Agranulocytosis"],"prefix":"10.2169","volume":"53","author":[{"given":"Hiroyoshi","family":"Kino","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Tsukuba Medical Center Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromichi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Tsukuba Medical Center Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tsukuba Medical Center Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Koiso","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tsukuba Medical Center Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiro","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tsukuba Medical Center Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Uemura","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tsukuba Medical Center Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Tsukuba Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"962","reference":[{"key":"1","unstructured":"1. Andersohn F, Bronder E, Klimpel A, Garbe E. Proportion of drug-related serious rare blood dyscrasias: estimates from the Berlin Case-Control Surveillance Study. Am J Hematol 77: 316-318, 2004."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Kaufman DW, Kelly JP, Jurgelon JM, et al. Drugs in the aetiology of agranulocytosis and aplastic anaemia. Eur J Haematol Suppl 60: 23-30, 1996.","DOI":"10.1111\/j.1600-0609.1996.tb01641.x"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Ishimaru N, Ohnishi H, Nishiuma T, et al. Antithyroid drug-induced agranulocytosis complicated by pneumococcal sepsis and upper airway obstruction. Intern Med 52: 2355-2359, 2013.","DOI":"10.2169\/internalmedicine.52.0220"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Garbe E. Non-chemotherapy drug-induced agranulocytosis. Expert Opin Drug Saf 6: 323-335, 2007.","DOI":"10.1517\/14740338.6.3.323"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Bozikas VP, Garyfallos G, Nikolaidis N, Partsafyllidis D, Fokas K. Pregabalin induced neutropenia. Prog Neuropsychopharmacol Biol Psychiatry 32: 907-908, 2008.","DOI":"10.1016\/j.pnpbp.2007.12.023"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Derbyshire E, Martin D. Neutropenia occurring after starting gabapentin for neuropathic pain. Clin Oncol (R Coll Radiol) 16: 575-576, 2004.","DOI":"10.1016\/j.clon.2004.06.015"},{"key":"7","unstructured":"7. Janarthanan S, Ditah I, Adler DG, Ehrinpreis MN. Clostridium difficile-associated diarrhea and proton pump inhibitor therapy: a meta-analysis. Am J Gastroenterol 107: 1001-1010, 2012."},{"key":"8","unstructured":"8. Vesteinsdottir I, Gudlaugsdottir S, Einarsdottir R, Kalaitzakis E, Sigurdardottir O, Bjornsson ES. Risk factors for Clostridium difficile toxin-positive diarrhea: a population-based prospective case-control study. Eur J Clin Microbiol Infect Dis 31: 2601-2610, 2012."},{"key":"9","unstructured":"9. Pakyz AL, Jawahar R, Wang Q, Harpe SE. Medication risk factors associated with healthcare-associated Clostridium difficile infection: a multilevel model case-control study among 64 US academic medical centres. J Antimicrob Chemother 69: 1127-1131, 2014."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Gorschluter M, Glasmacher A, Hahn C, et al. Clostridium difficile infection in patients with neutropenia. Clin Infect Dis 33: 786-791, 2001.","DOI":"10.1086\/322616"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Shannon-Lowe J, Matheson NJ, Cooke FJ, Aliyu SH. Prevention and medical management of Clostridium difficile infection. BMJ 340: c1296, 2010.","DOI":"10.1136\/bmj.c1296"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Baidya DK, Agarwal A, Khanna P, Arora MK. Pregabalin in acute and chronic pain. J Anaesthesiol Clin Pharmacol 27: 307-314, 2011.","DOI":"10.4103\/0970-9185.83672"},{"key":"13","unstructured":"13. Bryans JS, Wustrow DJ. 3-substituted GABA analogs with central nervous system activity: a review. Med Res Rev 19: 149-177, 1999."},{"key":"14","unstructured":"14. Tassone DM, Boyce E, Guyer J, Nuzum D. Pregabalin: a novel gamma-aminobutyric acid analogue in the treatment of neuropathic pain, partial-onset seizures, and anxiety disorders. Clin Ther 29: 26-48, 2007."},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Choy E, Richards S, Bowrin K, et al. Cost effectiveness of pregabalin in the treatment of fibromyalgia from a UK perspective. Curr Med Res Opin 26: 965-975, 2010.","DOI":"10.1185\/03007991003600271"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Rivera-Castano L, Leal-Cantu R, Abreu P, Guerrero M, Davila G. A 21-week open-label clinical trial of pregabalin as adjunctive therapy in partial seizures at multiple centers in Mexico (PREPS Mexico). Epilepsy Res 100: 74-79, 2012.","DOI":"10.1016\/j.eplepsyres.2012.01.009"},{"key":"17","unstructured":"17. Montgomery SA, Tobias K, Zornberg GL, Kasper S, Pande AC. Efficacy and safety of pregabalin in the treatment of generalized anxiety disorder: a 6-week, multicenter, randomized, double-blind, placebo-controlled comparison of pregabalin and venlafaxine. J Clin Psychiatry 67: 771-782, 2006."},{"key":"18","unstructured":"18. Semel D, Murphy TK, Zlateva G, Cheung R, Emir B. Evaluation of the safety and efficacy of pregabalin in older patients with neuropathic pain: results from a pooled analysis of 11 clinical studies. BMC Fam Pract 11: 85, 2010."},{"key":"19","unstructured":"19. De Smedt RH, Jaarsma T, van den Broek SA, Haaijer-Ruskamp FM. Decompensation of chronic heart failure associated with pregabalin in a 73-year-old patient with postherpetic neuralgia: a case report. Br J Clin Pharmacol 66: 327-328, 2008."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Smith TL, Baldwin A, Cunningham LL Jr, Cook AM. Rash associated with pregabalin use. Ann Pharmacother 42: 1899-1902, 2008.","DOI":"10.1345\/aph.1L305"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Sendra JM, Junyent TT, Pellicer MJ. Pregabalin-induced hepatotoxicity. Ann Pharmacother 45: e32, 2011.","DOI":"10.1345\/aph.1Q032"},{"key":"22","unstructured":"22. Arroyo S, Anhut H, Kugler AR, et al. Pregabalin add-on treatment: a randomized, double-blind, placebo-controlled, dose-response study in adults with partial seizures. Epilepsia 45: 20-27, 2004."},{"key":"23","unstructured":"23. Kamel JT, D'Souza WJ, Cook MJ. Severe and disabling constipation: an adverse effect of pregabalin. Epilepsia 51: 1094-1096, 2010."}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/53\/18\/53_53.2085\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T17:51:49Z","timestamp":1621446709000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/53\/18\/53_53.2085\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":23,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.53.2085","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}