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The effect of legislation on synthetic cannabinoid abuse in Ireland. Clin Toxicol 49: 240, 2011."},{"key":"11","unstructured":"11. http:\/\/www.mhlw.go.jp\/stf\/seisakunitsuite\/bunya\/kenkou_iryou\/iyakuhin\/yakubuturanyou\/index.html [Accessed 1 September, 2014]."},{"key":"12","unstructured":"12. Fattore L, Fratta W. Beyond THC: the new generation of cannabinoid designer drugs. Front Behav Neurosci 5: 60, 2011."},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Atwood BK, Huffman J, Straiker A, Makcie K. JWH-018, a common constituent of 'Spice' herbal blends, is a potent and efficacious cannabinoid CB1 receptor agonist. Br J Pharmacol 160: 585-593, 2010.","DOI":"10.1111\/j.1476-5381.2009.00582.x"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Wintermeyer A, Moller I, Thevis M, et al. <i>In vitro<\/i> phase I metabolism of the synthetic cannabimimetic JWH-018. 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From \"Special K\" to \"Special M\": the evolution of the recreational use of ketamine and methoxetamine. CNS Neurosci Ther 19: 454-460, 2013."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Jansen KLR. Near-death experiences and the NMDA receptor. BMJ 298: 1708, 1989.","DOI":"10.1136\/bmj.298.6689.1708-b"},{"key":"21","unstructured":"21. Schields JE, Dargan PI, Wood DM, Puchnarewicz M, Davies S, Waring WS. Methoxetamine associated reversible cerebellar toxicity: Three cases with analytical confirmation. Clin Toxicol 50: 438-440, 2012."},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Wood DM, Davies S, Puchnarewicz M, Johnston A, Dargan PI. Acute toxicity associated with the recreational use of the ketamine derivative methoxetamine. Eur J Clin Pharmacol 68: 853-856, 2012.","DOI":"10.1007\/s00228-011-1199-9"},{"key":"23","unstructured":"23. Wood DM, Dargan PI. 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