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Parry TE. Proceedings: two cases of neuroblastoma with marrow findings mimicking acute leukaemia. Arch Dis Child 49: 497, 1974.","DOI":"10.1136\/adc.49.6.497"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Lou Y, Meng H, Mao L, Jin J. Bone marrow relapse of medulloblastoma mimicking acute leukemia with translocation (1;18)(p33;q22). J Clin Oncol 29: e24-e26, 2011.","DOI":"10.1200\/JCO.2010.30.8999"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Anand M, Kumar R, Jain P, et al. Metastatic anaplastic oligodendroglioma simulating acute leukemia. A case report. Acta Cytol 47: 467-469, 2003.","DOI":"10.1159\/000326552"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Enzinger FM, Shiraki M. Alveolar rhabdomyosarcoma. An analysis of 110 cases. Cancer 24: 18-31, 1969.","DOI":"10.1002\/1097-0142(196907)24:1<18::AID-CNCR2820240103>3.0.CO;2-5"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. McDowell HP. Update on childhood rhabdomyosarcoma. Arch Dis Child 88: 354-357, 2003.","DOI":"10.1136\/adc.88.4.354"},{"key":"6","unstructured":"6. Kahn DG. Rhabdomyosarcoma mimicking acute leukemia in an adult: report of a case with histologic, flow cytometric, cytogenetic, immunohistochemical, and ultrastructural studies. Arch Pathol Lab Med 122: 375-378, 1998."},{"key":"7","unstructured":"7. Naito H, de Higa EH, Kobayashi R, Shikano T, Ishikawa Y, Nojima T. Alveolar rhabdomyosarcoma with massive bone marrow involvement and 2;13 chromosome translocation. Rinsho Ketsueki (The Japanese Journal of Clinical Hematology) 33: 238-243, 1992 (in Japanese, Abstract in English)."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Sandberg AA, Stone JF, Czarnecki L, Cohen JD. Hematologic masquerade of rhabdomyosarcoma. Am J Hematol 68: 51-57, 2001.","DOI":"10.1002\/ajh.1148"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Shinkoda Y, Nagatoshi Y, Fukano R, Nishiyama K, Okamura J. Rhabdomyosarcoma masquerading as acute leukemia. Pediatr Blood Cancer 52: 286-287, 2009.","DOI":"10.1002\/pbc.21783"},{"key":"10","unstructured":"10. Srinivas U, Pillai L, Kar R, Mahapatra M, Gujra S, Pati HP. A case of rhabdomyosarcoma masquerading as acute leukemia at presentation: a case report. Indian J Pathol Microbiol 50: 917-919, 2007."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Arndt CA, Nascimento AG, Schroeder G, et al. Treatment of intermediate risk rhabdomyosarcoma and undifferentiated sarcoma with alternating cycles of vincristine\/doxorubicin\/cyclophosphamide and etoposide\/ifosfamide. Eur J Cancer 34: 1224-1229, 1998.","DOI":"10.1016\/S0959-8049(98)00080-X"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Raney RB, Anderson JR, Barr FG, et al. Rhabdomyosarcoma and undifferentiated sarcoma in the first two decades of life: a selective review of intergroup rhabdomyosarcoma study group experience and rationale for Intergroup Rhabdomyosarcoma Study V. J Pediatr Hematol Oncol 23: 215-220, 2001.","DOI":"10.1097\/00043426-200105000-00008"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Wang C. Childhood rhabdomyosarcoma: recent advances and prospective views. J Dent Res 91: 341-350, 2012.","DOI":"10.1177\/0022034511421490"},{"key":"14","unstructured":"14. Dagher R, Helman L. Rhabdomyosarcoma: an overview. Oncologist 4: 34-44, 1999."},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Ferrari A, Dileo P, Casanova M, et al. Rhabdomyosarcoma in adults. A retrospective analysis of 171 patients treated at a single institution. Cancer 98: 571-580, 2003.","DOI":"10.1002\/cncr.11550"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Breneman JC, Lyden E, Pappo AS, et al. Prognostic factors and clinical outcomes in children and adolescents with metastatic rhabdomyosarcoma: a report from the Intergroup Rhabdomyosarcoma Study IV. J Clin Oncol 21: 78-84, 2003.","DOI":"10.1200\/JCO.2003.06.129"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Wagemans J, Beuselinck B, Nuyts S, et al. A case series of embryonal rhabdomyosarcoma of the head and neck in adults. Acta Clin Belg 65: 404-410, 2010.","DOI":"10.1179\/acb.2010.65.6.006"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Callender TA, Weber RS, Janjan N, et al. Rhabdomyosarcoma of the nose and paranasal sinuses in adults and children. Otolaryngol Head Neck Surg 112: 252-257, 1995.","DOI":"10.1016\/S0194-5998(95)70246-6"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Prestidge BR, Donaldson SS. Treatment results among adults with childhood tumors: a 20-year experience. Int J Radiat Oncol Biol Phys 17: 507-514, 1989.","DOI":"10.1016\/0360-3016(89)90101-6"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Lloyd RV, Hajdu SI, Knapper WH. Embryonal rhabdomyosarcoma in adults. Cancer 51: 557-565, 1983.","DOI":"10.1002\/1097-0142(19830201)51:3<557::AID-CNCR2820510333>3.0.CO;2-E"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Nayar RC, Prudhomme F, Parise O Jr, Gandia D, Luboinski B, Schwaab G. Rhabdomyosarcoma of the head and neck in adults: a study of 26 patients. Laryngoscope 103: 1362-1366, 1993.","DOI":"10.1288\/00005537-199312000-00008"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Ali R, Ozkalemkas F, Ozan U, et al. Rhabdomyosarcoma of the perianal region presenting as acute leukemia. Ann Hematol 83: 729-730, 2004.","DOI":"10.1007\/s00277-004-0912-5"},{"key":"23","unstructured":"23. Ambrosiani L, Bellone S, Betto FS, et al. Rhabdomyosarcoma presenting as acute hematologic malignancy: case report and review of the literature. Tumori 82: 408-412, 1996."},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Chen L, Shah HO, Lin JH. Alveolar rhabdomyosarcoma with concurrent metastases to bone marrow and lymph nodes simulating acute hematologic malignancy. J Pediatr Hematol Oncol 26: 696-697, 2004.","DOI":"10.1097\/01.mph.0000140654.50344.92"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Curry S, Bacon CL, Robinson I, Capra M, Smith OP. Leukaemic alveolar rhabdomyosarcoma. Br J Haematol 151: 208, 2010.","DOI":"10.1111\/j.1365-2141.2010.08338.x"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Fitzmaurice RJ, Johnson PR, Yin JA, Freemont AJ. Rhabdomyosarcoma presenting as 'acute leukaemia'. Histopathology 18: 173-175, 1991.","DOI":"10.1111\/j.1365-2559.1991.tb01462.x"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Haisa T, Kondo T, Miwa A, Saitoh K. Cervical epidural rhabdomyosarcoma with a leukemia-like presentation in an aged patient: case report. Neurol Med Chir (Tokyo) 39: 234-237, 1999.","DOI":"10.2176\/nmc.39.234"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Maywald O, Metzgeroth G, Schoch C, et al. Alveolar rhabdomyosarcoma with bone marrow infiltration mimicking haematological neoplasia. Br J Haematol 119: 583, 2002.","DOI":"10.1046\/j.1365-2141.2002.03860.x"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Morandi S, Manna A, Sabattini E, Porcellini A. Rhabdomyosarcoma presenting as acute leukemia. J Pediatr Hematol Oncol 18: 305-307, 1996.","DOI":"10.1097\/00043426-199608000-00015"},{"key":"30","unstructured":"30. Putti MC, Montaldi A, D'Emilio A, et al. Unusual leukemic presentation of rhabdomyosarcoma: report of two cases with immunological, ultrastructural and cytogenetical studies. Haematologica 76: 368-374, 1991."},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Reinecke P, Gerharz CD, Thiele KP, et al. Temporary remission of an alveolar rhabdomyosarcoma diagnosed and treated as acute leukemia. Leuk Lymphoma 36: 405-409, 2000.","DOI":"10.3109\/10428190009148862"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Sabattini E, Falini B, Pileri S. Rhabdomyosarcoma presenting as 'acute leukaemia'. Histopathology 19: 575-576, 1991.","DOI":"10.1111\/j.1365-2559.1991.tb01512.x"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Stindl R, Fiegl M, Regele H, Gisslinger H, Breitenseher MJ, Fonatsch C. Alveolar rhabdomyosarcoma in a 68-year-old patient identified by cytogenetic analysis of bone marrow. Cancer Genet Cytogenet 107: 43-47, 1998.","DOI":"10.1016\/S0165-4608(98)00061-2"},{"key":"34","unstructured":"34. Yamaguchi K, Koga Y, Suminoe A, et al. Alveolar rhabdomyosarcoma of unknown origin mimicking acute leukemia at the initial presentation. Rinsho Ketsueki (The Japanese Journal of Clinical Hematology) 48: 315-320, 2007 (in Japanese, Abstract in English)."},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Locatelli F, Tonani P, Porta F, et al. Rhabdomyosarcoma with primary osteolytic lesions simulating non-Hodgkin's lymphoma. Pediatr Hematol Oncol 8: 159-164, 1991.","DOI":"10.3109\/08880019109033443"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Miyoshi I, Uemura Y, Muneishi H, Miyazaki J, Taguchi H. Bone marrow metastasis of alveolar rhabdomyosarcoma. Intern Med 44: 677-678, 2005.","DOI":"10.2169\/internalmedicine.44.677"},{"key":"37","unstructured":"37. P&eacute;rez del R&iacute;o MJ, Fresno Forcelledo MF, Ram&iacute;rez P&aacute;yer A, et al. [Alveolar rhabdomyosarcoma with massive infiltration of the bone marrow as its initial manifestation]. Sangre (Barc) 43: 236-239, 1998 (in Spanish, Abstract in English)."},{"key":"38","unstructured":"38. Mechtersheimer G, Staudter M, Moller P. Expression of the natural killer cell-associated antigens CD56 and CD57 in human neural and striated muscle cells and in their tumors. Cancer Res 51: 1300-1307, 1991."},{"key":"39","unstructured":"39. Knapp W. Leucocyte typing IV: White Cell Differentiation Antigens. Oxford University Press, Oxford, 1989."},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Chang A, Benda PM, Wood BL, Kussick SJ. Lineage-specific identification of nonhematopoietic neoplasms by flow cytometry. Am J Clin Pathol 119: 643-655, 2003.","DOI":"10.1309\/FU3FDKYN8AU0891N"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Gardner LJ, Polski JM, Fallon R, Dunphy CH. Identification of CD56 and CD57 by flow cytometry in Ewing's sarcoma or primitive neuroectodermal tumor. Virchows Arch 433: 35-40, 1998.","DOI":"10.1007\/s004280050213"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Bryson GJ, Lear D, Williamson R, Wong RC. Detection of the CD56+\/CD45- immunophenotype by flow cytometry in neuroendocrine malignancies. J Clin Pathol 55: 535-537, 2002.","DOI":"10.1136\/jcp.55.7.535"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Stock N, Chibon F, Binh MB, et al. Adult-type rhabdomyosarcoma: analysis of 57 cases with clinicopathologic description, identification of 3 morphologic patterns and prognosis. Am J Surg Pathol 33: 1850-1859, 2009.","DOI":"10.1097\/PAS.0b013e3181be6209"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Parham DM, Webber B, Holt H, Williams WK, Maurer H. Immunohistochemical study of childhood rhabdomyosarcomas and related neoplasms. Results of an Intergroup Rhabdomyosarcoma study project. Cancer 67: 3072-3080, 1991.","DOI":"10.1002\/1097-0142(19910615)67:12<3072::AID-CNCR2820671223>3.0.CO;2-Z"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Truong LD, Rangdaeng S, Cagle P, Ro JY, Hawkins H, Font RL. The diagnostic utility of desmin. A study of 584 cases and review of the literature. Am J Clin Pathol 93: 305-314, 1990.","DOI":"10.1093\/ajcp\/93.3.305"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Dodd S, Malone M, McCulloch W. Rhabdomyosarcoma in children: a histological and immunohistochemical study of 59 cases. J Pathol 158: 13-18, 1989.","DOI":"10.1002\/path.1711580105"},{"key":"47","unstructured":"47. Shapiro DN, Sublett JE, Li B, Downing JR, Naeve CW. Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma. Cancer Res 53: 5108-5112, 1993."},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. Galili N, Davis RJ, Fredericks WJ, et al. Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma. Nat Genet 5: 230-235, 1993.","DOI":"10.1038\/ng1193-230"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Sorensen PH, Lynch JC, Qualman SJ, et al. PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group. J Clin Oncol 20: 2672-2679, 2002.","DOI":"10.1200\/JCO.2002.03.137"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Raney RB, Maurer HM, Anderson JR, et al. The Intergroup Rhabdomyosarcoma Study Group (IRSG): Major Lessons From the IRS-I Through IRS-IV Studies as Background for the Current IRS-V Treatment Protocols. Sarcoma 5: 9-15, 2001.","DOI":"10.1080\/13577140120048890"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51. Arndt CA, Hawkins DS, Meyer WH, Sencer SF, Neglia JP, Anderson JR. Comparison of results of a pilot study of alternating vincristine\/doxorubicin\/cyclophosphamide and etoposide\/ifosfamide with IRS-IV in intermediate risk rhabdomyosarcoma: a report from the Children's Oncology Group. 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