{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T09:48:26Z","timestamp":1768988906462,"version":"3.49.0"},"reference-count":23,"publisher":"Japanese Society of Internal Medicine","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2015]]},"DOI":"10.2169\/internalmedicine.54.3363","type":"journal-article","created":{"date-parts":[[2015,5,31]],"date-time":"2015-05-31T22:05:44Z","timestamp":1433109944000},"page":"1381-1384","source":"Crossref","is-referenced-by-count":6,"title":["Lung Cancer Associated with Seronegative Myasthenia Gravis"],"prefix":"10.2169","volume":"54","author":[{"given":"Kyoko","family":"Niimi","sequence":"first","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichiro","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tokai University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Murata","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Horio","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Takiguchi","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Tomomatsu","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuyoshi","family":"Tomomatsu","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Hayama","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Oguma","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Aoki","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Urano","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Abe","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chie","family":"Inomoto","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tokai University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunya","family":"Takizawa","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tokai University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Asano","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Nair SG, Kumar BS, Rajan B. Poorly differentiated carcinoma of the lung presenting with Lambert-Eaton myasthenic syndrome. Am J Clin Oncol 23: 58-59, 2000.","DOI":"10.1097\/00000421-200002000-00016"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Fujita J, Yamadori I, Yamaji Y, Yamagishi Y, Takigawa K, Takahara J. Myasthenia gravis associated with small-cell carcinoma of the lung. Chest 105: 624-625, 1994.","DOI":"10.1378\/chest.105.2.624"},{"key":"3","unstructured":"3. Hazard PB, Bertorini TE, Griffin JP. Myasthenia gravis associated with small cell carcinoma of the lung. J Tenn Med Assoc 79: 273-276, 1986."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Kataoka K, Fujiwara T, Matsuura M, Seno N. A case of simultaneously operated primary multiple lung cancers with non-thymomatous myasthenia gravis. Jpn J Lung Cancer 49: 273-277, 2008.","DOI":"10.2482\/haigan.49.273"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Leavitt JA. Myasthenia gravis with a paraneoplastic marker. J Neuroophthalmol 20: 102-105, 2000.","DOI":"10.1097\/00041327-200020020-00008"},{"key":"6","unstructured":"6. Miyoshi R, Yamaji Y, Shima S, Fujita J, Okada H, Takahara J. A case of small cell lung cancer that developed during therapy for myasthenia gravis. Nihon Kyobu Shikkan Gakkai Zasshi (The Japanese Journal of Thoracic Diseases) 33: 456-462, 1995 (in Japanese, Abstract in English)."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Ohira M, Jeong D, Oh SJ. Seropositive myasthenia gravis associated with small-cell lung carcinoma. J Clin Neurol 7: 43-46, 2011.","DOI":"10.3988\/jcn.2011.7.1.43"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Peltier AC, Black BK, Raj SR, Donofrio P, Robertson D, Biaggioni I. Coexistent autoimmune autonomic ganglionopathy and myasthenia gravis associated with non-small-cell lung cancer. Muscle Nerve 41: 416-419, 2010.","DOI":"10.1002\/mus.21528"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Sakamaki Y, Yoon HE, Oda N. Non-small-cell lung cancer associated with non-thymomatous myasthenia gravis. Jpn J Thorac Cardiovasc Surg 54: 207-211, 2006.","DOI":"10.1007\/BF02670314"},{"key":"10","unstructured":"10. Shaygannejad V, Ghasemi M, Rajaee Z. Myasthenia gravis as a presenting feature in a patient with lung cancer: A case report. J Res Med Sci 16: 229-232, 2011."},{"key":"11","unstructured":"11. Takagi M, Akiba T. A case of surgically treated primary lung cancer with myasthenia gravis. Nihon Kokyuki Gakkai Zasshi 45: 198-201, 2007 (in Japanese, Abstract in English)."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Takizawa M, Oda M, Matsumoto I, Waseda R, Tanaka N, Watanabe G. Myasthenia gravis complicated with lung cancer and middle mediastinal thymoma. Asian Cardiovasc Thorac Ann 20: 486-488, 2012.","DOI":"10.1177\/0218492312440264"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Hoch W, McConville J, Helms S, Newsom-Davis J, Melms A, Vincent A. Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies. Nat Med 7: 365-368, 2001.","DOI":"10.1038\/85520"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Higuchi O, Hamuro J, Motomura M, Yamanashi Y. Autoantibodies to low-density lipoprotein receptor-related protein 4 in myasthenia gravis. Ann Neurol 69: 418-422, 2011.","DOI":"10.1002\/ana.22312"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Pevzner A, Schoser B, Peters K, et al. Anti-LRP4 autoantibodies in AChR- and MuSK-antibody-negative myasthenia gravis. J Neurol 259: 427-435, 2012.","DOI":"10.1007\/s00415-011-6194-7"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Papatestas AE, Osserman KE, Kark AE. The relationship between thymus and oncogenesis. A study of the incidence of non thymic malignancy in myasthenia gravis. Br J Cancer 25: 635-645, 1971.","DOI":"10.1038\/bjc.1971.79"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Levin N, Abramsky O, Lossos A, et al. Extrathymic malignancies in patients with myasthenia gravis. J Neurol Sci 237: 39-43, 2005.","DOI":"10.1016\/j.jns.2005.05.009"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Monden Y, Uyama T, Kimura S, Taniki T. Extrathymic malignancy in patients with myasthenia gravis. Eur J Cancer 27: 745-747, 1991.","DOI":"10.1016\/0277-5379(91)90179-H"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Gilhus NE, Willcox N, Harcourt G, et al. Antigen presentation by thymoma epithelial cells from myasthenia gravis patients to potentially pathogenic T cells. J Neuroimmunol 56: 65-76, 1995.","DOI":"10.1016\/0165-5728(94)00134-A"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Okumura M, Inoue M, Kadota Y, et al. Biological implications of thymectomy for myasthenia gravis. Surg Today 40: 102-107, 2010.","DOI":"10.1007\/s00595-009-4134-2"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Mihovilovic M, Hulette C, Mittelstaedt J, Austin C, Roses AD. Nicotinic neuronal acetylcholine receptor alpha-3 subunit transcription in normal and myasthenic thymus. Ann N Y Acad Sci 681: 83-96, 1993.","DOI":"10.1111\/j.1749-6632.1993.tb22872.x"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Maus AD, Pereira EF, Karachunski PI, et al. Human and rodent bronchial epithelial cells express functional nicotinic acetylcholine receptors. Mol Pharmacol 54: 779-788, 1998.","DOI":"10.1124\/mol.54.5.779"},{"key":"23","unstructured":"23. Zia S, Ndoye A, Nguyen VT, Grando SA. Nicotine enhances expression of the α3, α4, α5, and α7 nicotinic receptors modulating calcium metabolism and regulating adhesion and motility of respiratory epithelial cells. Res Commun Mol Pathol Pharmacol 97: 243-262, 1997."}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","deposited":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T21:58:59Z","timestamp":1566770339000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/54\/11\/54_54.3363\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":23,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.54.3363","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}