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Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 341: 709-717, 1999.","DOI":"10.1056\/NEJM199909023411001"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Pitt B, Remme W, Zannad F, et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 348: 1309-1321, 2003.","DOI":"10.1056\/NEJMoa030207"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Zannad F, McMurray JJ, Krum H, et al. Eplerenone in patients with systolic heart failure and mild symptoms. N Engl J Med 364: 11-21, 2011.","DOI":"10.1056\/NEJMoa1009492"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Takai S, Jin D, Muramatsu M, et al. Eplerenone inhibits atherosclerosis in nonhuman primates. 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Boesby L, Elung-Jensen T, Strandgaard S, Kamper AL. Eplerenone attenuates pulse wave refletion in chronic kidney disease stage 3-4 a randomized controlled study. PLoS One 8: 1-9, 2013.","DOI":"10.1371\/journal.pone.0064549"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Hwang MH, Yoo JK, Luttrell M, et al. Role of mineralocorrticoid receptors in arterial stiiffness in human aging. Exp Gerontol 48: 701-704, 2013.","DOI":"10.1016\/j.exger.2013.05.058"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Delyani JA, Rocha R, Cook CS, et al. Eplerenone: a selective aldosterone receptor antagonist (SARA). Cardiovasc Drug Rev 19: 185-200, 2001.","DOI":"10.1111\/j.1527-3466.2001.tb00064.x"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. McMahon EG. Recent studies with eplerenone, a novel selective aldosterone receptor antagonist. 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