{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:24:59Z","timestamp":1767677099699},"reference-count":26,"publisher":"Japanese Society of Internal Medicine","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2015]]},"DOI":"10.2169\/internalmedicine.54.3800","type":"journal-article","created":{"date-parts":[[2015,6,30]],"date-time":"2015-06-30T22:05:59Z","timestamp":1435701959000},"page":"1619-1622","source":"Crossref","is-referenced-by-count":8,"title":["Portosystemic Encephalopathy without Liver Cirrhosis Masquerading as Depression"],"prefix":"10.2169","volume":"54","author":[{"given":"Takanori","family":"Asakura","sequence":"first","affiliation":[{"name":"Department of General Internal Medicine, National Hospital Organization Tokyo Medical Center, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobutake","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Radiology, National Hospital Organization Tokyo Medical Center, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Sohma","sequence":"additional","affiliation":[{"name":"Department of Radiology, National Hospital Organization Tokyo Medical Center, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuaki","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, National Hospital Organization Tokyo Medical Center, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Watanabe A. Portal-systemic encephalopathy in non-cirrhotic patients: classification of clinical types, diagnosis and treatment. J Gastroenterol Hepatol 15: 969-979, 2000.","DOI":"10.1046\/j.1440-1746.2000.02283.x"},{"key":"2","unstructured":"2. Akahoshi T, Nishizaki T, Wakasugi K, et al. Portal-systemic encephalopathy due to a congenital extrahepatic portosystemic shunt: three cases and literature review. Hepatogastroenterology 47: 1113-1116, 2000."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Mori H, Hayashi K, Fukuda T, et al. Intrahepatic portosystemic venous shunt: occurrence in patients with and without liver cirrhosis. Am J Roentgenol 149: 711-714, 1987.","DOI":"10.2214\/ajr.149.4.711"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Saijyo S, Kudo T, Suzuki M, et al. Establishment of a new extrahepatic bile duct carcinoma cell line, TFK-1. Tohoku J Exp Med 177: 61-71, 1995.","DOI":"10.1620\/tjem.177.61"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Nishimoto Y, Hoshino H, Sato S, et al. Extrahepatic portosystemic venous shunt without portal hypertension. Intern Med 36: 886-889, 1997.","DOI":"10.2169\/internalmedicine.36.886"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Otake M, Kobayashi Y, Hashimoto D, et al. An inferior mesenteric-caval shunt via the internal iliac vein with portosystemic encephalopathy. Intern Med 40: 887-890, 2001.","DOI":"10.2169\/internalmedicine.40.887"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. KCS, Matsutani S, Maruyama H, et al. Portal-systemic encephalopathy in two patients without liver cirrhosis and portal hypertension. Hepatol Res 23: 122-129, 2002.","DOI":"10.1016\/S1386-6346(01)00171-1"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Tanaka O, Ishihara K, Oyamada H, et al. Successful portal-systemic shunt occlusion with balloon-occluded retrograde transvenous obliteration for portosystemic encephalopathy without liver cirrhosis. J Vasc Interv Radiol 17: 1951-1955, 2006.","DOI":"10.1097\/01.RVI.0000250890.38012.38"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Park SW, Kang HS, Kim YJ, Lee MW, Roh HG. Successful occlusion of spontaneous portosystemic shunts leading to encephalopathy in a non-cirrhotic patient by using the amplatzer vascular plug. Acta Radiol 48: 1077-1081, 2007.","DOI":"10.1080\/02841850701545847"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Miyata K, Tamai H, Uno A, et al. Congenital portal systemic encephalopathy misdiagnosed as senile dementia. Intern Med 48: 321-324, 2009.","DOI":"10.2169\/internalmedicine.48.1777"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Saito M, Seo Y, Yano Y, et al. Successful treatment using coil embolization of a symptomatic intrahepatic portosystemic venous shunt developing through a patent ductus venosus in a noncirrhotic adult. Intern Med 52: 555-559, 2013.","DOI":"10.2169\/internalmedicine.52.9110"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Takeuchi H, Takeda Y, Takahashi M, Hayashi S, Fukuzawa Y, Nakano T. A rare congenital extrahepatic portosystemic shunt affecting the inferior mesenteric vein, inferior vena cava, and left ovarian vein. Surg Radiol Anat 36: 729-732, 2014.","DOI":"10.1007\/s00276-013-1230-1"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Yokota T, Tsuchiya K, Umetani K, Furukawa T, Tsukagoshi H. Choreoathetoid movements associated with a spleno-renal shunt. J Neurol 235: 487-488, 1988.","DOI":"10.1007\/BF00314253"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Ohwada S, Hamada Y, Morishita Y, et al. Hepatic encephalopathy due to congenital splenorenal shunts: report of a case. Surg Today 24: 145-149, 1994.","DOI":"10.1007\/BF02473397"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Kuramitsu T, Komatsu M, Matsudaira N, et al. Portal-systemic encephalopathy from a spontaneous gastrorenal shunt diagnosed by three-dimensional computed tomography and treated effectively by percutaneous vascular embolization. Liver 18: 208-212, 1998.","DOI":"10.1111\/j.1600-0676.1998.tb00152.x"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Raskin NH, Price JB, Fishman RA. Portal-systemic encephalopathy due to congenital intrahepatic shunts. N Engl J Med 270: 225-229, 1964.","DOI":"10.1056\/NEJM196401302700503"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Kerlan RK, Sollenberger RD, Palubinskas AJ, Raskin NH, Callen PW, Ehrenfeld WK. Portal-systemic encephalopathy due to a congenital portocaval shunt. AJR Am J Roentgenol 139: 1013-1015, 1982.","DOI":"10.2214\/ajr.139.5.1013"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Ali S, Stolpen AH, Schmidt WN. Portosystemic encephalopathy due to mesoiliac shunt in a patient without cirrhosis. J Clin Gastroenterol 44: 381-383, 2010.","DOI":"10.1097\/MCG.0b013e3181aae51b"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Tsai CW, Kuo CC, Huang CC. Spontaneous, non-cirrhotic, intrahepatic porto-systemic shunt presenting as acute encephalopathy. Liver Int 34: 1603, 2014.","DOI":"10.1111\/liv.12432"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Kiriyama M, Takashima S, Sahara H, et al. Case report: portal-systemic encephalopathy due to a congenital extrahepatic portosystemic shunt. J Gastroenterol Hepatol 11: 626-629, 1996.","DOI":"10.1111\/j.1440-1746.1996.tb00304.x"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Albrecht J, Jones EA. Hepatic encephalopathy: molecular mechanisms underlying the clinical syndrome. J Neurol Sci 170: 138-146, 1999.","DOI":"10.1016\/S0022-510X(99)00169-0"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Shimoda R, Horiuchi K, Hagiwara S, et al. Short-term complications of retrograde transvenous obliteration of gastric varices in patients with portal hypertension: effects of obliteration of major portosystemic shunts. Abdom Imaging 30: 306-313, 2005.","DOI":"10.1007\/s00261-004-0270-8"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Cho SK, Shin SW, Lee IH, et al. Balloon-occluded retrograde transvenous obliteration of gastric varices: outcomes and complications in 49 patients. AJR Am J Roentgenol 189: W365-W372, 2007.","DOI":"10.2214\/AJR.07.2266"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Schaer DJ, Buehler PW, Alayash AI, Belcher JD, Vercellotti GM. Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins. Blood 121: 1276-1284, 2013.","DOI":"10.1182\/blood-2012-11-451229"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Hashizume M, Kitano S, Yamaga H, Sugimachi K. Haptoglobin to protect against renal damage from ethanolamine oleate sclerosant. Lancet 2: 340-341, 1988.","DOI":"10.1016\/S0140-6736(88)92400-2"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Laleman W, Simon-Talero M, Maleux G, et al. Embolization of large spontaneous portosystemic shunts for refractory hepatic encephalopathy: a multicenter survey on safety and efficacy. Hepatology 57: 2448-2457, 2013.","DOI":"10.1002\/hep.26314"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","deposited":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T21:35:15Z","timestamp":1566941715000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/54\/13\/54_54.3800\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":26,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.54.3800","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}