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Tab&aacute;k AG, Jokela M, Akbaraly TN, Brunner EJ, Kivim&auml;ki M, Witte DR. Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study. Lancet 373: 2215-2221, 2009.","DOI":"10.1016\/S0140-6736(09)60619-X"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Kosaka K, Akanuma Y. Heterogeneity of plasma IRI responses in patients with IGT. Diabetologia 18: 347-348, 1980.","DOI":"10.1007\/BF00251018"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Kadowaki T, Miyake Y, Hagura R, et al. Risk factors for worsening to diabetes in subjects with impaired glucose tolerance. Diabetologia 26: 44-49, 1984.","DOI":"10.1007\/BF00252262"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. U.K. Prospective Diabetes Study Group. U.K. prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. Diabetes 44: 1249-1258, 1995.","DOI":"10.2337\/diab.44.11.1249"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Sakuraba H, Mizukami H, Yagihashi N, Wada R, Hanyu C, Yagihashi S. Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients. Diabetologia 45: 85-96, 2002.","DOI":"10.1007\/s125-002-8248-z"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. &beta;-Cell deficit and increased &beta;-cell apoptosis in humans with type 2 diabetes. Diabetes 52: 102-110, 2003.","DOI":"10.2337\/diabetes.52.1.102"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Lorenzo A, Razzaboni B, Weir GC, Yankner BA. Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus. Nature 368: 756-760, 1994.","DOI":"10.1038\/368756a0"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Clark A, Cooper GJ, Lewis CE, et al. Islet amyloid formed from diabetes-associated peptide may be pathogenic in type-2 diabetes. Lancet 2: 231-234, 1987.","DOI":"10.1016\/S0140-6736(87)90825-7"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Eizirik DL, Korbutt GS, Hellerstr&ouml;m C. Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell function. J Clin Invest 90: 1263-1268, 1992.","DOI":"10.1172\/JCI115989"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Marshak S, Leibowitz G, Bertuzzi F, et al. Impaired beta-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose. Diabetes 48: 1230-1236, 1999.","DOI":"10.2337\/diabetes.48.6.1230"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Maedler K, Spinas GA, Lehmann R, et al. Glucose induces &beta;-cell apoptosis via upregulation of the Fas-receptor in human islets. Diabetes 50: 1683-1690, 2001.","DOI":"10.2337\/diabetes.50.8.1683"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Federici M, Hribal M, Perego L, et al. High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program. Diabetes 50: 1290-1301, 2001.","DOI":"10.2337\/diabetes.50.6.1290"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Eizirik DL, Cardozo AK, Cnop M. The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev 29: 42-61, 2008.","DOI":"10.1210\/er.2007-0015"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 140: 900-917, 2010.","DOI":"10.1016\/j.cell.2010.02.034"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Oslowski CM, Hara T, O'Sullivan-Murphy B, et al. Thioredoxin-interacting protein mediates ER stress-induced &beta; cell death through initiation of the inflammasome. Cell Metab 16: 265-273, 2012.","DOI":"10.1016\/j.cmet.2012.07.005"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Seino Y, Nanjo K, Tajima N, et al. Report of the committee on the classification and diagnostic criteria of diabetes mellitus. J Diabetes Investig 1: 212-228, 2010.","DOI":"10.1111\/j.2040-1124.2010.00074.x"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Kashiwagi A, Kasuga M, Araki E, et al. International clinical harmonization of glycated hemoglobin in Japan: from Japan Diabetes Society to National Glycohemoglobin Standardization Program values. J Diabetes Investig 3: 39-40, 2012.","DOI":"10.1111\/j.2040-1124.2012.00207.x"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Peacock I, Tattersall RB. The difficult choice of treatment for poorly controlled maturity onset diabetes: tablets or insulin? Br Med J (Clin Res Ed) 288: 1956-1959, 1984.","DOI":"10.1136\/bmj.288.6435.1956"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Funakoshi S, Fujimoto S, Hamasaki A, et al. Utility of indices using C-peptide levels for indication of insulin therapy to achieve good glycemic control in Japanese patients with type 2 diabetes. J Diabetes Investig 2: 297-303, 2011.","DOI":"10.1111\/j.2040-1124.2010.00096.x"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Iwata M, Matsushita Y, Fukuda K, et al. Secretory units of islets in transplantation index is a useful predictor of insulin requirement in Japanese type 2 diabetic patients. J Diabetes Investig 5: 570-580, 2014.","DOI":"10.1111\/jdi.12181"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Levy J, Atkinson AB, Bell PM, McCance DR, Hadden DR. Beta-cell deterioration determines the onset and rate of progression of secondary dietary failure in type 2 diabetes mellitus: the 10-year follow-up of the Belfast Diet Study. Diabet Med 15: 290-296, 1998.","DOI":"10.1002\/(SICI)1096-9136(199804)15:4<290::AID-DIA570>3.0.CO;2-M"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Bagust A, Beale S. Deteriorating beta-cell function in type 2 diabetes: a long-term model. QJM 96: 281-288, 2003.","DOI":"10.1093\/qjmed\/hcg040"},{"key":"23","unstructured":"23. Festa A, Williams K, Hanley AJ, Haffner SM. &beta;-Cell dysfunction in subjects with impaired glucose tolerance and early type 2 diabetes: comparison of surrogate markers with first-phase insulin secretion from an intravenous glucose tolerance test. Diabetes 57: 1638-1644, 2008."},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Alvarsson M, Sundkvist G, Lager I, et al. Beneficial effects of insulin versus sulphonylurea on insulin secretion and metabolic control in recently diagnosed type 2 diabetic patients. Diabetes Care 26: 2231-2237, 2003.","DOI":"10.2337\/diacare.26.8.2231"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Funakoshi S, Fujimoto S, Hamasaki A, et al. Analysis of factors influencing pancreatic beta-cell function in Japanese patients with type 2 diabetes: association with body mass index and duration of diabetic exposure. Diabetes Res Clin Pract 82: 353-358, 2008.","DOI":"10.1016\/j.diabres.2008.09.010"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Inzucchi SE, Bergenstal RM, Buse JB, et al; American Diabetes Association (ADA); European Association for the Study of Diabetes (EASD). Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 35: 1364-1379, 2012.","DOI":"10.2337\/dc12-0413"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Lingvay I, Legendre JL, Kaloyanova PF, Zhang S, Adams-Huet B, Raskin P. Insulin-based versus triple oral therapy for newly diagnosed type 2 diabetes: which is better? Diabetes Care 32: 1789-1795, 2009.","DOI":"10.2337\/dc09-0653"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Jurgens CA, Toukatly MN, Fligner CL, et al. &beta;-Cell loss and &beta;-cell apoptosis in human type 2 diabetes are related to islet amyloid deposition. Am J Pathol 178: 2632-2640, 2011.","DOI":"10.1016\/j.ajpath.2011.02.036"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. El-Assaad W, Buteau J, Peyot ML, et al. Saturated fatty acids synergize with elevated glucose to cause pancreatic &beta;-cell death. Endocrinology 144: 4154-4163, 2003.","DOI":"10.1210\/en.2003-0410"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Nakamura M, Kitamura H, Konishi S, et al. The endocrine pancreas of spontaneously diabetic db\/db mice: microangiopathy as revealed by transmission electron microscopy. Diabetes Res Clin Pract 30: 89-100, 1995.","DOI":"10.1016\/0168-8227(95)01155-2"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Giroix MH, Irminger JC, Lacraz G, et al. Hypercholesterolaemia, signs of islet microangiopathy and altered angiogenesis precede onset of type 2 diabetes in the Goto-Kakizaki (GK) rat. 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